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Htr6
Gene Detail
Symbol

Name
ID
Htr6
5-hydroxytryptamine (serotonin) receptor 6
MGI:1196627
Synonyms
5-HT6
Feature Type
protein coding gene
Genetic Map
Chromosome 4
70.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:139061108-139075570 bp, - strand
From VEGA annotation of GRCm38

  14463 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:673  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HTR6
Protein SuperFamily: 5-hydroxytryptamine receptor 6
Gene Tree: Htr6

Human
homologs
HTR6, 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3362
neXtProt AC: NX_P50406

Human Synonyms: 5-HT6, 5-HT6R

Human Chr (Location): 1p36-p35; chr1:19665287-19680966 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Htr6 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for some disruptions in this gene display decreased body size. Mice homozygous for a different null allele display decreased sensitivity to alcohol induced behavioral responses.
 
Interactions
Htr6 interacts with 27 markers (Mir1a-1, Mir1a-2, Mir93, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cerebral cortex cell migration, G-protein coupled receptor signaling pathway, ...
Component cilium, dendrite, ...
Function G-protein coupled receptor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(6)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000009899 (Evidence)
Ensembl Gene Model ENSMUSG00000028747 (Evidence)
Entrez Gene 15565 (Evidence)
UniGene 291096
DoTS DT.55133988, DT.87035141
NIA Mouse Gene Index U025694
Consensus CDS Project CCDS18838.1
International Mouse Phenotyping Consortium Status Htr6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009899 VEGA Gene Model | MGI Sequence Detail 14463 C57BL/6J ±  kb
transcript OTTMUST00000022954 VEGA | MGI Sequence Detail 2341 Not Applicable 
polypeptide OTTMUSP00000010478 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(210 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001102 5-hydroxytryptamine receptor 6
References
(Earliest) J:43429 Cox GA, et al., Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell. 1997 Oct 3;91(1):139-48
(Latest) J:215912 Jacobshagen M, et al., The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism. Development. 2014 Sep;141(17):3370-7
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory