Htr6
Gene Detail

Symbol Name ID

Htr6 5-hydroxytryptamine (serotonin) receptor 6 MGI:1196627

Synonyms

5-HT6

Feature Type

protein coding gene

Genetic Map

Chromosome 4

70.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:139061108-139075570 bp, - strand From VEGA annotation of GRCm38   14463 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Htr6 ± 2 cM)

Protein SuperFamily: 5-hydroxytryptamine receptor 6
Gene Tree: Htr6

Human ortholog

HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled NCBI Gene ID 3362
Human Synonyms: 5-HT6, 5-HT6R
Human Chr1:19991780-20006055 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Male mice homozygous for some disruptions in this gene display decreased body size. Mice homozygous for a different null allele display decreased sensitivity to alcohol induced behavioral responses.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, ...
Component	cilium, dendrite, ...
Function	G-protein coupled receptor activity, serotonin receptor activity, ...

External Resources: FuncBase

Expression

cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000009899 (Evidence)
Ensembl Gene Model	ENSMUSG00000028747 (Evidence)
Entrez Gene	15565 (Evidence)
UniGene	291096
DoTS	DT.55133988, DT.87035141
NIA Mouse Gene Index	U025694
Consensus CDS Project	CCDS18838.1
International Mouse Knockout Project Status	Htr6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009899	VEGA Gene Model | MGI Sequence Detail	14463	C57BL/6J
transcript	OTTMUST00000022954	VEGA | MGI Sequence Detail	2341	Not Applicable
polypeptide	OTTMUSP00000010478	VEGA | MGI Sequence Detail	440	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

PCR(1) : SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001102	5-hydroxytryptamine receptor 6

References

(Earliest) J:43429 Cox GA, et al., Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell. 1997 Oct 3;91(1):139-48
(Latest) J:182871 Lai CK, et al., Functional characterization of putative cilia genes by high-content analysis. Mol Biol Cell. 2011 Apr;22(7):1104-19
All references(31)