About   Help   FAQ
Htr6 Gene Detail
Summary
  • Symbol
    Htr6
  • Name
    5-hydroxytryptamine (serotonin) receptor 6
  • Synonyms
    5-HT6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196627
    NCBI Gene: 15565
  • Gene Overview
    MyGene.info: HTR6
Location & Maps
more
  • Sequence Map
    Chr4:139061108-139075570 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14463 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    HTR6, 5-hydroxytryptamine receptor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HTR6, 5-hydroxytryptamine receptor 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    5-HT6, 5-HT6R
  • Links
    NCBI Gene ID: 3362
    neXtProt AC: NX_P50406

  • Chr Location
    1p36-p35; chr1:19665287-19680966 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Targeted
    6
  • Genomic Mutations
    3 involving Htr6
  • Incidental Mutations
Male mice homozygous for some disruptions in this gene display decreased body size. Mice homozygous for a different null allele display decreased sensitivity to alcohol induced behavioral responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009899 VEGA Gene Model | MGI Sequence Detail 14463 C57BL/6J ±  kb
transcript OTTMUST00000022954 VEGA | MGI Sequence Detail 2341 Not Applicable  
polypeptide OTTMUSP00000010478 VEGA | MGI Sequence Detail 440 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    210 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001102 5-hydroxytryptamine receptor 6
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
less
  • All nucleic 8
    cDNA 6
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 8
  • Earliest
    J:43429 Cox GA, et al., Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell. 1997 Oct 3;91(1):139-48
  • Latest
    J:215912 Jacobshagen M, et al., The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism. Development. 2014 Sep;141(17):3370-7

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory