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Htr6
Gene Detail
 Symbol
Name
ID
Htr6
5-hydroxytryptamine (serotonin) receptor 6
MGI:1196627
Synonyms 5-HT6
Feature Type protein coding gene
Genetic Map
Chromosome 4
70.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:139061108-139075570 bp, - strand
From VEGA annotation of GRCm38

  14463 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:673  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 6
Gene Tree: Htr6

Human
homologs
Human Homolog HTR6, 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
NCBI Gene ID 3362
neXtProt AC  NX_P50406
Human Synonyms  5-HT6, 5-HT6R
Human Chr (Location)  1p36-p35; chr1:19665287-19680966 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Male mice homozygous for some disruptions in this gene display decreased body size. Mice homozygous for a different null allele display decreased sensitivity to alcohol induced behavioral responses.
 
Interactions
Htr6 interacts with 27 markers (Mir1a-1, Mir1a-2, Mir93, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process G-protein coupled receptor signaling pathway, G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger, ...
Component cilium, dendrite, ...
Function G-protein coupled receptor activity, serotonin receptor activity, ...
External Resources: FuncBase
Expression
cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(7) cDNA(6) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000009899 (Evidence)
Ensembl Gene ModelENSMUSG00000028747 (Evidence)
Entrez Gene15565 (Evidence)
UniGene291096
DoTSDT.55133988, DT.87035141
NIA Mouse Gene IndexU025694
Consensus CDS ProjectCCDS18838.1
International Mouse Knockout Project StatusHtr6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009899 VEGA Gene Model | MGI Sequence Detail 14463 C57BL/6J ±  kb
transcript OTTMUST00000022954 VEGA | MGI Sequence Detail 2341 Not Applicable 
polypeptide OTTMUSP00000010478 VEGA | MGI Sequence Detail 440 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(210 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001102 5-hydroxytryptamine receptor 6
References (Earliest) J:43429 Cox GA, et al., Sodium/hydrogen exchanger gene defect in slow-wave epilepsy mutant mice. Cell. 1997 Oct 3;91(1):139-48
(Latest) J:182871 Lai CK, et al., Functional characterization of putative cilia genes by high-content analysis. Mol Biol Cell. 2011 Apr;22(7):1104-19
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory