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Tcea1 Gene Detail
Summary
  • Symbol
    Tcea1
  • Name
    transcription elongation factor A (SII) 1
  • Synonyms
    S-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196624
    NCBI Gene: 21399
  • Gene Overview
    MyGene.info: TCEA1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:4857814-4897909 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 1.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    255 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196624
protein coding gene Chr1:4857694-4897909 (.)
129S1/SvImJ MGP_129S1SvImJ_G0015813
protein coding gene Chr1:1898279-1937789 (+)
A/J MGP_AJ_G0015795
protein coding gene Chr1:1974811-2016497 (+)
AKR/J MGP_AKRJ_G0015754
protein coding gene Chr1:1957747-1999676 (+)
BALB/cJ MGP_BALBcJ_G0015751
protein coding gene Chr1:1901656-1943287 (+)
C3H/HeJ MGP_C3HHeJ_G0015585
protein coding gene Chr1:1934180-1975946 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016203
protein coding gene Chr1:2008441-2053249 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013925
protein coding gene Chr1:1644531-1678218 (+)
CAST/EiJ MGP_CASTEiJ_G0015165
protein coding gene Chr1:2112093-2158652 (+)
CBA/J MGP_CBAJ_G0015559
protein coding gene Chr1:2122115-2168631 (+)
DBA/2J MGP_DBA2J_G0015657
protein coding gene Chr1:1883399-1924482 (+)
FVB/NJ MGP_FVBNJ_G0015662
protein coding gene Chr1:1851922-1893573 (+)
LP/J MGP_LPJ_G0015730
protein coding gene Chr1:2077756-2122635 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015681
protein coding gene Chr1:2284362-2328882 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016250
protein coding gene Chr1:1916335-1960593 (+)
PWK/PhJ MGP_PWKPhJ_G0014949
protein coding gene Chr1:1819135-1856866 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014729
protein coding gene Chr1:2092736-2132881 (+)
WSB/EiJ MGP_WSBEiJ_G0015229
protein coding gene Chr1:1917422-1960779 (+)



Homology
more
  • Human Ortholog
    TCEA1, transcription elongation factor A1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TCEA1, transcription elongation factor A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GTF2S, SII, TCEA, TF2S, TFIIS
  • Links
    NCBI Gene ID: 6917
    neXtProt AC: NX_P23193
    UniProt: P23193

  • Chr Location
    8q11.23; chr8:53966554-54022456 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired definitive erythropoiesis with loss of late stage erythroblasts, fetal liver hypoplasia, and embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033813 Ensembl Gene Model | MGI Sequence Detail 40096 C57BL/6J ±  kb
    transcript ENSMUST00000165720 Ensembl | MGI Sequence Detail 2854 Not Applicable  
    polypeptide ENSMUSP00000129157 Ensembl | MGI Sequence Detail 312 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR035441 TFIIS/LEDGF domain superfamily
      IPR035100 Transcription elongation factor, IIS-type
      IPR003618 Transcription elongation factor S-II, central domain
      IPR036575 Transcription elongation factor S-II, central domain superfamily
      IPR006289 Transcription elongation factor, TFIIS
      IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
      IPR017923 Transcription factor IIS, N-terminal
      IPR001222 Zinc finger, TFIIS-type
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 29
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1196623
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 4
    • Earliest
      J:33182 Hirashima S, et al., Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II. J Biol Chem. 1988 Mar 15;263(8):3858-63
    • Latest
      J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory