About   Help   FAQ
Tcea1 Gene Detail
Summary
  • Symbol
    Tcea1
  • Name
    transcription elongation factor A (SII) 1
  • Synonyms
    S-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196624
    NCBI Gene: 21399
  • Gene Overview
    MyGene.info: TCEA1
Location & Maps
more
  • Genetic Map
    Chromosome 1, 1.79 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TCEA1, transcription elongation factor A1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TCEA1, transcription elongation factor A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GTF2S, SII, TCEA, TF2S, TFIIS
  • Links
    NCBI Gene ID: 6917
    neXtProt AC: NX_P23193

  • Chr Location
    8q11.2; chr8:53966554-54022456 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Incidental Mutations
Homozygous null mice display impaired definitive erythropoiesis with loss of late stage erythroblasts, fetal liver hypoplasia, and embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042348 VEGA Gene Model | MGI Sequence Detail 40096 C57BL/6J ±  kb
transcript OTTMUST00000111603 VEGA | MGI Sequence Detail 2854 Not Applicable  
polypeptide OTTMUSP00000062524 VEGA | MGI Sequence Detail 312 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    255 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016157 transcription elongation factor A protein 1
  • InterPro Domains
    IPR003618 Transcription elongation factor S-II, central domain
    IPR006289 Transcription elongation factor, TFIIS
    IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
    IPR016492 Transcription elongation factor, TFIIS-related
    IPR017923 Transcription factor IIS, N-terminal
    IPR001222 Zinc finger, TFIIS-type
Molecular
Reagents
less
  • All nucleic 29
    cDNA 27
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1196623
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:33182 Hirashima S, et al., Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II. J Biol Chem. 1988 Mar 15;263(8):3858-63
  • Latest
    J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory