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Tcea1
Gene Detail
 Symbol
Name
ID
Tcea1
transcription elongation factor A (SII) 1
MGI:1196624
Synonyms S-II
Feature Type protein coding gene
Genetic Map
Chromosome 1
1.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:4857814-4897909 bp, + strand
From VEGA annotation of GRCm38

  40096 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55984  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription elongation factor, IIS type
Gene Tree: Tcea1

Human
homologs
Human Homolog TCEA1, transcription elongation factor A (SII), 1
NCBI Gene ID 6917
neXtProt AC  NX_P23193
Human Synonyms  GTF2S, SII, TCEA, TF2S, TFIIS
Human Chr (Location)  8q11.2; chr8:53966554-54022456 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix )
 
Homozygous null mice display impaired definitive erythropoiesis with loss of late stage erythroblasts, fetal liver hypoplasia, and embryonic lethality.
 
Interactions
Tcea1 interacts with 244 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process erythrocyte differentiation, positive regulation of transcription, DNA-templated, ...
Component nucleolus, nucleoplasm, ...
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (88)    Tissues (56)    Images (7)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 28
Assay TypeResults
RNA in situ 78
Western blot 2
RT-PCR 8
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(27) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000042348 (Evidence)
Ensembl Gene ModelENSMUSG00000033813 (Evidence)
Entrez Gene21399 (Evidence)
DFCITC1573595
DoTSDT.101377874, DT.101377876, DT.523276, DT.55269413, DT.91394586, DT.94344452, DT.99871571
NIA Mouse Gene IndexU000008, U085044
Consensus CDS ProjectCCDS35505.1, CCDS48212.1
International Mouse Knockout Project StatusTcea1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042348 VEGA Gene Model | MGI Sequence Detail 40096 C57BL/6J ±  kb
transcript OTTMUST00000111603 VEGA | MGI Sequence Detail 2854 Not Applicable 
polypeptide OTTMUSP00000062524 VEGA | MGI Sequence Detail 312 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(6) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(255 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003618 Transcription elongation factor S-II, central domain
InterPro IPR017890 Transcription elongation factor S-IIM
InterPro IPR006289 Transcription elongation factor, TFIIS
InterPro IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
InterPro IPR016492 Transcription elongation factor, TFIIS-related
InterPro IPR017923 Transcription factor IIS, N-terminal
InterPro IPR001222 Zinc finger, TFIIS-type
Protein Ontology PR:000016157 transcription elongation factor A protein 1
References (Earliest) J:33182 Hirashima S, et al., Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II. J Biol Chem. 1988 Mar 15;263(8):3858-63
(Latest) J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
All references(37)
Other
accession IDs
MGI:1196623

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory