Rbpjl MGI Mouse Gene Detail - MGI:1196616 - recombination signal binding protein for immunoglobulin kappa J region-like

Symbol

Rbpjl
Name

recombination signal binding protein for immunoglobulin kappa J region-like
Synonyms

RBP-J kappa-like, RBP-L, Rbpsuhl

Feature Type

protein coding gene
IDs

MGI:1196616
NCBI Gene: 19668
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:164245061-164257368 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 85.16 cM
Mapping Data

2 experiments

SNPs within 2kb

519 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196616	protein coding gene	Chr2:164244996-164257368 (+)
129S1/SvImJ	ENSMUSG00200016493	protein coding gene	Chr2:161132056-161144229 (+)
A/J	ENSMUSG00195017375	protein coding gene	Chr2:161465877-161478104 (+)
AKR/J	ENSMUSG00220013346	protein coding gene	Chr2:160788438-160800660 (+)
BALB/cJ	ENSMUSG00180045527	protein coding gene	Chr2:160919637-160931867 (+)
C3H/HeJ	ENSMUSG00175049646	protein coding gene	Chr2:161665647-161677907 (+)
C57BL/6NJ	ENSMUSG00215018854	protein coding gene	Chr2:161116914-161129167 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024643	protein coding gene	Chr2:156340943-156353474 (+)
CAST/EiJ	ENSTCUG00005045551	protein coding gene	Chr2:160036463-160048799 (+)
CBA/J	ENSMUSG00210015837	protein coding gene	Chr2:161600333-161612561 (+)
DBA/2J	ENSMUSG00185048716	protein coding gene	Chr2:161332846-161345104 (+)
FVB/NJ	ENSMUSG00205033338	protein coding gene	Chr2:160353715-160365980 (+)
JF1/MsJ	ENSUMUG00000011731	protein coding gene	Chr2:160976532-160988881 (+)
LP/J	ENSMUSG00230041360	protein coding gene	Chr2:162893149-162905320 (+)
NOD/ShiLtJ	ENSMUSG00190042199	protein coding gene	Chr2:161005170-161017401 (+)
NZO/HlLtJ	ENSMUSG00225052180	protein coding gene	Chr2:170895183-170907444 (+)
PWK/PhJ	ENSLUMG00010043892	protein coding gene	Chr2:160879602-160891965 (+)
SPRET/EiJ	ENSMSPG00010034483	protein coding gene	Chr2:163643586-163655840 (+)
WSB/EiJ	ENSIUOG00005041232	protein coding gene	Chr2:160726277-160738431 (+)

Human Ortholog

RBPJL, recombination signal binding protein for immunoglobulin kappa J region like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RBPJL, recombination signal binding protein for immunoglobulin kappa J region like
Synonyms

RBPL, RBPSUHL, SUHL
Links

HGNC:13761

NCBI Gene ID: 11317

UniProt: Q9UBG7
Chr Location

20q13.12; chr20:45306840-45317824 (+) GRCh38

MGI Vertebrate Homology

Rbpjl stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RBPJL
Gene Tree

Rbpjl

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

5
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available

Mice homozygous for disruptions in this gene do not display any obvious phenotype abnormalities.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

56
cDNA Data

22
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

6
UniProt

2
CCDS

CCDS17035.1

Ensembl

ENSMUSG00000017007 (Evidence)
NCBI Gene

19668

			Length	Strain/Species	Flank
genomic	ENSMUSG00000017007	Ensembl Gene Model \| MGI Sequence Detail	12308	C57BL/6J	± kb
transcript	ENSMUST00000017151	Ensembl \| MGI Sequence Detail	2456	Not Applicable
polypeptide	ENSMUSP00000017151	Ensembl \| MGI Sequence Detail	515	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000013825 recombining binding protein suppressor of hairless-like protein

(term hierarchy)
InterPro Domains

IPR015350 Beta-trefoil DNA-binding domain

IPR036358 Beta-trefoil domain superfamily

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR008967 p53-like transcription factor, DNA-binding domain superfamily

IPR015351 RBP-J/Cbf11/Cbf12, DNA binding

IPR037095 RBP-J/Cbf11, DNA binding domain superfamily

IPR038007 RBP-Jkappa, IPT domain

IPR040159 Suppressor of hairless-like

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All nucleic 23

cDNA 22

Primer pair 1

Microarray probesets 4

Summaries

All 54

Developmental Gene Expression 16

Gene Ontology 8

Phenotypes 10
Earliest

J:40289 Minoguchi S, et al., RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol. 1997 May;17(5):2679-87
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rbpjl:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21578	Chr2:164245122-164245139 (+)	70 bp
Tssr21579	Chr2:164246290-164246320 (+)	1,244 bp
Tssr21580	Chr2:164247184-164247217 (+)	2,140 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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