Slc4a1ap MGI Mouse Gene Detail - MGI:1196608 - solute carrier family 4 (anion exchanger), member 1, adaptor protein

Symbol

Slc4a1ap
Name

solute carrier family 4 (anion exchanger), member 1, adaptor protein
Synonyms

kanadaptin

Feature Type

protein coding gene
IDs

MGI:1196608
NCBI Gene: 20534
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr5:31684339-31714276 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.27 cM
Mapping Data

2 experiments

SNPs within 2kb

136 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196608	protein coding gene	Chr5:31684125-31723318 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029429	protein coding gene	Chr5:29549304-29582307 (+)
A/J	MGP_AJ_G0029395	protein coding gene	Chr5:28600310-28630507 (+)
AKR/J	MGP_AKRJ_G0029345	protein coding gene	Chr5:29751201-29781299 (+)
BALB/cJ	MGP_BALBcJ_G0029406	protein coding gene	Chr5:29130724-29161168 (+)
C3H/HeJ	MGP_C3HHeJ_G0029127	protein coding gene	Chr5:29770766-29802630 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029859	protein coding gene	Chr5:31376596-31406198 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027097	protein coding gene	Chr5:26204696-26233764 (+)
CAST/EiJ	MGP_CASTEiJ_G0028537	protein coding gene	Chr5:28807001-28838939 (+)
CBA/J	MGP_CBAJ_G0029095	protein coding gene	Chr5:32007125-32040288 (+)
DBA/2J	MGP_DBA2J_G0029244	protein coding gene	Chr5:28760986-28791120 (+)
FVB/NJ	MGP_FVBNJ_G0029202	protein coding gene	Chr5:28181083-28210844 (+)
LP/J	MGP_LPJ_G0029329	protein coding gene	Chr5:30001184-30033011 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029231	protein coding gene	Chr5:32834470-32868050 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029893	protein coding gene	Chr5:29249079-29278858 (+)
PWK/PhJ	MGP_PWKPhJ_G0028262	protein coding gene	Chr5:27915526-27949446 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028093	protein coding gene	Chr5:28712059-28743972 (+)
WSB/EiJ	MGP_WSBEiJ_G0028618	protein coding gene	Chr5:29318149-29350243 (+)

Human Ortholog

SLC4A1AP, solute carrier family 4 member 1 adaptor protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC4A1AP, solute carrier family 4 member 1 adaptor protein
Synonyms

HLC3
Links

HGNC:13813

NCBI Gene ID: 22950

neXtProt AC: NX_Q9BWU0

UniProt: Q9BWU0
Chr Location

2p23.3; chr2:27663426-27695366 (+) GRCh38

MGI Vertebrate Homology

Slc4a1ap stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC4A1AP
Gene Tree

Slc4a1ap

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

4
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

5 involving Slc4a1ap
Incidental Mutations

APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

56

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc4a1ap

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All Sequences

81
RefSeq

20
UniProt

12
CCDS

CCDS51460.1, CCDS84865.1, CCDS89902.1

Ensembl

ENSMUSG00000029141 (Evidence)
NCBI Gene

20534

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029141	Ensembl Gene Model \| MGI Sequence Detail	29938	C57BL/6J	± kb
transcript	ENSMUST00000202950	Ensembl \| MGI Sequence Detail	2499	Not Applicable
polypeptide	ENSMUSP00000144257	Ensembl \| MGI Sequence Detail	744	Not Applicable

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UniProt

12 Sequences
InterPro Domains

IPR014720 Double-stranded RNA-binding domain

IPR000253 Forkhead-associated (FHA) domain

IPR008984 SMAD/FHA domain superfamily

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All nucleic 57

cDNA 57

Microarray probesets 2

Summaries

All 51

Diseases 1

Gene Ontology 3

Phenotypes 30
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Slc4a1ap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45713	Chr5:31684333-31684378 (+)	17 bp
Tssr45714	Chr5:31684408-31684419 (+)	75 bp
Tssr45715	Chr5:31684449-31684456 (+)	114 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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