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Fndc3a Gene Detail
Summary
  • Symbol
    Fndc3a
  • Name
    fibronectin type III domain containing 3A
  • Synonyms
    1700094E19Rik, D14Ertd453e, F730017H24Rik, Fndc3, sys
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196463
    NCBI Gene: 319448
  • Gene Overview
    MyGene.info: FNDC3A
Location & Maps
more
  • Sequence Map
    Chr14:72537946-72710003 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      172058 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 37.62 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    FNDC3A, fibronectin type III domain containing 3A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FNDC3A, fibronectin type III domain containing 3A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA203I16.1, bA203I16.5, FNDC3, HUGO
  • Links
    NCBI Gene ID: 22862
    neXtProt AC: NX_Q9Y2H6

  • Chr Location
    13q14.2; chr13:48975912-49209779 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    1
  • Gene trapped
    27
  • Targeted
    2
  • Transgenic
    1
  • Genomic Mutations
    1 involving Fndc3a
  • Incidental Mutations
    Mutagenetix , APF , CvDC
Males homozygous for an insertional mutation are sterile; females are fertile. In mutant males, spermatids form multinucleated syncytia and fail to mature, while Sertoli cells exhibit abnormal cytoplasmic vacuoles.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    20
  • Tissues
    8
  • cDNA Data
    15
  • Literature Summary
    1
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034682 VEGA Gene Model | MGI Sequence Detail 172058 C57BL/6J ±  kb
transcript OTTMUST00000088038 VEGA | MGI Sequence Detail 6143 Not Applicable  
polypeptide OTTMUSP00000047963 VEGA | MGI Sequence Detail 1198 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    677 from dbSNP Build 142
  • RFLP
    4
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000031510 fibronectin type-III domain-containing protein 3A
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
Molecular
Reagents
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  • All nucleic 20
    Genomic 2
    cDNA 17
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14691, MGI:1923886, MGI:2442045, MGI:98468
References
more
  • Summaries
    All 40
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:10611 MacGregor GR, et al., Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesis. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5016-20
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory