Fndc3a MGI Mouse Gene Detail - MGI:1196463 - fibronectin type III domain containing 3A

Fndc3a Gene Detail

Symbol

Fndc3a
Name

fibronectin type III domain containing 3A
Synonyms

1700094E19Rik, D14Ertd453e, F730017H24Rik, Fndc3, sys

Feature Type

protein coding gene
IDs

MGI:1196463
NCBI Gene: 319448
Gene Overview

MyGene.info: FNDC3A

Sequence Map

Chr14:72537946-72710003 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

172058 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 37.62 cM
Mapping Data

9 experiments

Human Ortholog

FNDC3A, fibronectin type III domain containing 3A

Vertebrate Orthologs

9

Human Ortholog

FNDC3A, fibronectin type III domain containing 3A
Orthology source: HomoloGene, HGNC
Synonyms

bA203I16.1, bA203I16.5, FNDC3, HUGO
Links

HGNC:20296

NCBI Gene ID: 22862

neXtProt AC: NX_Q9Y2H6

UniProt: Q9Y2H6
Chr Location

13q14.2; chr13:48975241-49209779 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 8952
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: FNDC3A
Gene Tree

Fndc3a

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Phenotype Summary

6 phenotypes from 2 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Chemically induced (other)

1
Gene trapped

27
Targeted

2
Transgenic

1
Genomic Mutations

1 involving Fndc3a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

42 strains or lines available

Males homozygous for an insertional mutation are sterile; females are fertile. In mutant males, spermatids form multinucleated syncytia and fail to mature, while Sertoli cells exhibit abnormal cytoplasmic vacuoles.

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All GO Annotations

13
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

20
Tissues

8
cDNA Data

15
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fndc3a, fndc3a

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Fndc3a interacts with 399 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

63
RefSeq

10
UniProt

5
CCDS

CCDS27264.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000034682	VEGA Gene Model \| MGI Sequence Detail	172058	C57BL/6J	± kb
transcript	OTTMUST00000088038	VEGA \| MGI Sequence Detail	6143	Not Applicable
polypeptide	OTTMUSP00000047963	VEGA \| MGI Sequence Detail	1198	Not Applicable

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SNPs within 2kb

677 from dbSNP Build 142

RFLP

4

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UniProt

5 Sequences
Protein Ontology

PR:000031510 fibronectin type-III domain-containing protein 3A

(term hierarchy)
InterPro Domains

IPR003961 Fibronectin type III

IPR013783 Immunoglobulin-like fold

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All nucleic 20

Genomic 2

cDNA 17

Primer pair 1

Microarray probesets 5

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MGD-MRK-14691, MGI:1923886, MGI:2442045, MGI:98468

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 12
Earliest

J:10611 MacGregor GR, et al., Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesis. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5016-20
Latest

J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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