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Fndc3a Gene Detail
Summary
  • Symbol
    Fndc3a
  • Name
    fibronectin type III domain containing 3A
  • Synonyms
    1700094E19Rik, D14Ertd453e, F730017H24Rik, Fndc3, sys
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196463
    NCBI Gene: 319448
  • Gene Overview
    MyGene.info: FNDC3A
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:72537946-72710003 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 37.62 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    677 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196463
 protein coding gene Chr14:72537946-72710683 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021552
 protein coding gene Chr14:67265398-67450724 (-)
A/J MGP_AJ_G0021511
 protein coding gene Chr14:65815432-65993172 (-)
AKR/J MGP_AKRJ_G0021487
 protein coding gene Chr14:67764869-67940963 (-)
BALB/cJ MGP_BALBcJ_G0021517
 protein coding gene Chr14:65578387-65748487 (-)
C3H/HeJ MGP_C3HHeJ_G0021294
 protein coding gene Chr14:67488824-67671045 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021956
 protein coding gene Chr14:70215826-70405422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019496
 protein coding gene Chr14:63569169-63722351 (-)
CAST/EiJ MGP_CASTEiJ_G0020811
 protein coding gene Chr14:64139562-64313374 (-)
CBA/J MGP_CBAJ_G0021261
 protein coding gene Chr14:72454012-72641709 (-)
DBA/2J MGP_DBA2J_G0021384
 protein coding gene Chr14:65198108-65368395 (-)
FVB/NJ MGP_FVBNJ_G0021363
 protein coding gene Chr14:64593743-64765274 (-)
LP/J MGP_LPJ_G0021455
 protein coding gene Chr14:68489859-68661046 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021392
 protein coding gene Chr14:71290491-71489245 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021980
 protein coding gene Chr14:67017863-67196225 (-)
PWK/PhJ MGP_PWKPhJ_G0020555
 protein coding gene Chr14:61960488-62135138 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020388
 protein coding gene Chr14:62994944-63166964 (-)
WSB/EiJ MGP_WSBEiJ_G0020864
 protein coding gene Chr14:67376168-67549955 (-)



Homology
more
  • Human Ortholog
    FNDC3A, fibronectin type III domain containing 3A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FNDC3A, fibronectin type III domain containing 3A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA203I16.1, bA203I16.5, FNDC3, HUGO
  • Links
    NCBI Gene ID: 22862
    neXtProt AC: NX_Q9Y2H6
    UniProt: Q9Y2H6

  • Chr Location
    13q14.2; chr13:48975241-49209779 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males homozygous for an insertional mutation are sterile; females are fertile. In mutant males, spermatids form multinucleated syncytia and fail to mature, while Sertoli cells exhibit abnormal cytoplasmic vacuoles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    27
  • Tissues
    13
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033487 Ensembl Gene Model | MGI Sequence Detail 172058 C57BL/6J ±  kb
    transcript ENSMUST00000089017 Ensembl | MGI Sequence Detail 6143 Not Applicable  
    polypeptide ENSMUSP00000086411 Ensembl | MGI Sequence Detail 1198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 19
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14691, MGI:1923886, MGI:2442045, MGI:98468
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:10611 MacGregor GR, et al., Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesis. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5016-20
    • Latest
      J:274320 Cao J, et al., The single-cell transcriptional landscape of mammalian organogenesis. Nature. 2019 Feb;566(7745):496-502
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/08/2019
    MGI 6.14     		The Jackson Laboratory