Scarb2
Gene Detail

Symbol Name ID

Scarb2 scavenger receptor class B, member 2 MGI:1196458

Synonyms

9330185J12Rik, Cd36l2, LGP85, LIMP-2, LIMP II

Feature Type

protein coding gene

Genetic Map

Chromosome 5

46.82 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:92443873-92505608 bp, - strand From NCBI annotation of GRCm38   61736 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:48353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: lysosomal integral membrane protein II
Gene Tree: Scarb2

Human homologs

Human Homolog		SCARB2, scavenger receptor class B, member 2
NCBI Gene ID		950
neXtProt AC		NX_Q14108
Human Synonyms		AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII
Human Chr (Location)		4q21.1; chr4:77079890-77135052 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SCARB2

Alleles and phenotypes

All alleles(116) : Targeted(2) Gene trapped(114)
 

Homozygous mutation of this gene results in renal dysfunction, progressive deafness, and progressive demylination of the peripheral nerves. Mutant animals show a 2-fold increased water consumption along with increased urine volume, and develop an enlarged, ball-like trunk with age.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	cell adhesion, protein targeting to lysosome
Component	integral to membrane, lysosomal lumen, ...
Function	enzyme binding, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (41)    Tissues (29)    Images (5)
Theiler Stages: 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	41

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(15)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000029426 (Evidence)
Entrez Gene	12492 (Evidence)
DFCI	TC1577821, TC1598432, TC1612711
DoTS	DT.530710, DT.97411924
NIA Mouse Gene Index	U026412
Consensus CDS Project	CCDS19431.1
International Mouse Knockout Project Status	Scarb2

Sequences

Length	Strain/Species
genomic	12492	NCBI Gene Model | MGI Sequence Detail	61736	C57BL/6J
transcript	NM_007644	RefSeq | MGI Sequence Detail	2110	C57BL/6
polypeptide	O35114	UniProt | EBI | MGI Sequence Detail	478	Not Applicable

All sequences(36) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(351 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002159	CD36 antigen
InterPro	IPR005429	Lysosome membrane protein II
Protein Ontology	PR:000014494	lysosome membrane protein 2

Graphical View of Protein Domain Structure

References

(Earliest) J:43932 Tabuchi N, et al., Identification and characterization of a major lysosomal membrane glycoprotein, LGP85/LIMP II in mouse liver. J Biochem. 1997 Oct;122(4):756-63
(Latest) J:194340 Lee D, et al., Limited capacity of proximal tubular proteolysis in mice with proteinuria. Am J Physiol Renal Physiol. 2013 Apr;304(7):F1009-19
All references(47)

Other accession IDs

MGI:2445131