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Scarb2
Gene Detail
Symbol

Name
ID
Scarb2
scavenger receptor class B, member 2
MGI:1196458
Synonyms
9330185J12Rik, Cd36l2, LGP85, LIMP-2, LIMP II
Feature Type
protein coding gene
Genetic Map
Chromosome 5
46.82 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:92441314-92506833 bp, - strand
From VEGA annotation of GRCm38

  65520 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: SCARB2
Protein SuperFamily: lysosomal integral membrane protein II
Gene Tree: Scarb2

Human
homologs
SCARB2, scavenger receptor class B, member 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 950
neXtProt AC: NX_Q14108

Human Synonyms: AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII

Human Chr (Location): 4q21.1; chr4:76158737-76213899 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SCARB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(116) : Gene trapped(114) Targeted(2)
Incidental mutations (data from APF , CvDC )
 
Homozygous mutation of this gene results in renal dysfunction, progressive deafness, and progressive demylination of the peripheral nerves. Mutant animals show a 2-fold increased water consumption along with increased urine volume, and develop an enlarged, ball-like trunk with age.
 
Interactions
Scarb2 interacts with 49 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell adhesion, protein targeting to lysosome
Component cell, extracellular exosome, ...
Function enzyme binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (41)    Tissues (30)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 41
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase scarb2 ; ZFIN scarb2    NEW 
Molecular
reagents
All nucleic(18) cDNA(18)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000055604 (Evidence)
Ensembl Gene Model ENSMUSG00000029426 (Evidence)
Entrez Gene 12492 (Evidence)
DFCI TC1577821, TC1598432, TC1612711
DoTS DT.530710, DT.97411924
NIA Mouse Gene Index U026412
Consensus CDS Project CCDS19431.1
International Mouse Phenotyping Consortium Status Scarb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055604 VEGA Gene Model | MGI Sequence Detail 65520 C57BL/6J ±  kb
transcript OTTMUST00000137618 VEGA | MGI Sequence Detail 4698 Not Applicable 
polypeptide OTTMUSP00000072453 VEGA | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(484 from dbSNP Build 137)    SNPs within 2kb including multiple locations(486)
Protein-related
information
ResourceIDDescription
InterPro IPR002159 CD36 antigen
InterPro IPR005429 Lysosome membrane protein II
Protein Ontology PR:000014494 lysosome membrane protein 2
References
(Earliest) J:43932 Tabuchi N, et al., Identification and characterization of a major lysosomal membrane glycoprotein, LGP85/LIMP II in mouse liver. J Biochem. 1997 Oct;122(4):756-63
(Latest) J:216676 Rothaug M, et al., LIMP-2 expression is critical for beta-glucocerebrosidase activity and alpha-synuclein clearance. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15573-8
All references(49)
Other
accession IDs
MGI:2445131

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory