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Scarb2
Gene Detail
 Symbol
Name
ID
Scarb2
scavenger receptor class B, member 2
MGI:1196458
Synonyms 9330185J12Rik, Cd36l2, LGP85, LIMP-2, LIMP II
Feature Type protein coding gene
Genetic Map
Chromosome 5
46.82 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:92443873-92505608 bp, - strand
From NCBI annotation of GRCm38

  61736 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48353  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: lysosomal integral membrane protein II
Gene Tree: Scarb2

Human
homologs
Human Homolog SCARB2, scavenger receptor class B, member 2
NCBI Gene ID 950
neXtProt AC  NX_Q14108
Human Synonyms  AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII
Human Chr (Location)  4q21.1; chr4:76158737-76213899 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SCARB2
Alleles
and
phenotypes
All alleles(116) : Gene trapped(114) Targeted(2)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in renal dysfunction, progressive deafness, and progressive demylination of the peripheral nerves. Mutant animals show a 2-fold increased water consumption along with increased urine volume, and develop an enlarged, ball-like trunk with age.
 
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell adhesion, protein targeting to lysosome
Component cell, extracellular vesicular exosome, ...
Function enzyme binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (41)    Tissues (29)    Images (5)
Theiler Stages: 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 41
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000029426 (Evidence)
Entrez Gene12492 (Evidence)
DFCITC1577821, TC1598432, TC1612711
DoTSDT.530710, DT.97411924
NIA Mouse Gene IndexU026412
Consensus CDS ProjectCCDS19431.1
International Mouse Knockout Project StatusScarb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12492 NCBI Gene Model | MGI Sequence Detail 61736 C57BL/6J ±  kb
transcript NM_007644 RefSeq | MGI Sequence Detail 2110 C57BL/6 
polypeptide O35114 UniProt | EBI | MGI Sequence Detail 478 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(478 from dbSNP Build 137)    SNPs within 2kb including multiple locations(480)
Protein-related
information
ResourceIDDescription
InterPro IPR002159 CD36 antigen
InterPro IPR005429 Lysosome membrane protein II
Protein Ontology PR:000014494 lysosome membrane protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:43932 Tabuchi N, et al., Identification and characterization of a major lysosomal membrane glycoprotein, LGP85/LIMP II in mouse liver. J Biochem. 1997 Oct;122(4):756-63
(Latest) J:204182 Gaspar P, et al., Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis. J Lipid Res. 2014 Jan;55(1):138-45
All references(48)
Other
accession IDs
MGI:2445131

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory