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Scarb2 Gene Detail
Summary
  • Symbol
    Scarb2
  • Name
    scavenger receptor class B, member 2
  • Synonyms
    9330185J12Rik, Cd36l2, LGP85, LIMP-2, LIMP II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196458
    NCBI Gene: 12492
  • Gene Overview
    MyGene.info: SCARB2
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:92441311-92505657 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 46.82 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    476 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196458
protein coding gene Chr5:92441311-92506833 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029752
protein coding gene Chr5:93640628-93704815 (-)
A/J MGP_AJ_G0029718
protein coding gene Chr5:89922115-89981769 (-)
AKR/J MGP_AKRJ_G0029664
protein coding gene Chr5:92857504-92923589 (-)
BALB/cJ MGP_BALBcJ_G0029728
protein coding gene Chr5:90795073-90855755 (-)
C3H/HeJ MGP_C3HHeJ_G0029451
protein coding gene Chr5:93260101-93321222 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030182
protein coding gene Chr5:97346305-97416330 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027418
protein coding gene Chr5:85559982-85621283 (-)
CAST/EiJ MGP_CASTEiJ_G0028861
protein coding gene Chr5:92638047-92701871 (-)
CBA/J MGP_CBAJ_G0029421
protein coding gene Chr5:100742040-100818043 (-)
DBA/2J MGP_DBA2J_G0029565
protein coding gene Chr5:89960754-90023428 (-)
FVB/NJ MGP_FVBNJ_G0029524
protein coding gene Chr5:88804939-88866302 (-)
LP/J MGP_LPJ_G0029653
protein coding gene Chr5:94001264-94064910 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029553
protein coding gene Chr5:105634230-105709675 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030216
protein coding gene Chr5:92380914-92448968 (-)
PWK/PhJ MGP_PWKPhJ_G0028580
protein coding gene Chr5:89027090-89088643 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028415
protein coding gene Chr5:91747506-91809703 (-)
WSB/EiJ MGP_WSBEiJ_G0028940
protein coding gene Chr5:92852196-92920127 (-)



Homology
more
  • Human Ortholog
    SCARB2, scavenger receptor class B member 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    SCARB2, scavenger receptor class B member 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII
  • Links
    NCBI Gene ID: 950
    neXtProt AC: NX_Q14108
    UniProt: Q14108

  • Chr Location
    4q21.1; chr4:76158737-76213899 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Scarb2 mouse models; 1 with human SCARB2 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 1 allele in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in renal dysfunction, progressive deafness, and progressive demylination of the peripheral nerves. Mutant animals show a 2-fold increased water consumption along with increased urine volume, and develop an enlarged, ball-like trunk with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12492 NCBI Gene Model | MGI Sequence Detail 64347 C57BL/6J ±  kb
    transcript NM_007644 RefSeq | MGI Sequence Detail 4729 C57BL/6  
    polypeptide O35114 UniProt | EBI | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2445131
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 26
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:258398 Conrad KS, et al., Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies. Nat Commun. 2017 Dec 4;8(1):1908

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory