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Scarb2 Gene Detail
Summary
  • Symbol
    Scarb2
  • Name
    scavenger receptor class B, member 2
  • Synonyms
    9330185J12Rik, Cd36l2, LGP85, LIMP-2, LIMP II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196458
    NCBI Gene: 12492
Location & Maps
more
  • Sequence Map
    Chr5:92441314-92506833 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65520 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SCARB2, scavenger receptor class B member 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    SCARB2, scavenger receptor class B member 2
    Orthology source: HomoloGene
  • Synonyms
    AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII
  • Links
    NCBI Gene ID: 950
    neXtProt AC: NX_Q14108

  • Chr Location
    4q21.1; chr4:76158737-76213899 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Scarb2 mouse models; 1 with human SCARB2 associations

Human Disease Mouse Models
       Epilepsy, Progressive Myoclonic, 4, with or without Renal Failure;   OMIM: 254900 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 1 allele in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    119
  • Chemically induced (other)
    1
  • Gene trapped
    114
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    3 involving Scarb2
  • Incidental Mutations
    APF , CvDC
Homozygous mutation of this gene results in renal dysfunction, progressive deafness, and progressive demylination of the peripheral nerves. Mutant animals show a 2-fold increased water consumption along with increased urine volume, and develop an enlarged, ball-like trunk with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055604 VEGA Gene Model | MGI Sequence Detail 65520 C57BL/6J ±  kb
transcript OTTMUST00000137618 VEGA | MGI Sequence Detail 4698 Not Applicable  
polypeptide OTTMUSP00000072453 VEGA | MGI Sequence Detail 478 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    484 from dbSNP Build 137
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000014494 lysosome membrane protein 2
  • InterPro Domains
    IPR002159 CD36 antigen
    IPR005429 Lysosome membrane protein II
Molecular
Reagents
less
  • All nucleic 18
    cDNA 18

    Microarray probesets 5
Other
Accession IDs
less
MGI:2445131
References
more
  • Summaries
    All 46
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 4
    Phenotypes 23
  • Earliest
    J:43932 Tabuchi N, et al., Identification and characterization of a major lysosomal membrane glycoprotein, LGP85/LIMP II in mouse liver. J Biochem. 1997 Oct;122(4):756-63
  • Latest
    J:216676 Rothaug M, et al., LIMP-2 expression is critical for beta-glucocerebrosidase activity and alpha-synuclein clearance. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15573-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory