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Scarb2 Gene Detail
Summary
  • Symbol
    Scarb2
  • Name
    scavenger receptor class B, member 2
  • Synonyms
    9330185J12Rik, Cd36l2, LGP85, LIMP-2, LIMP II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196458
    NCBI Gene: 12492
  • Gene Overview
    MyGene.info: SCARB2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:92441314-92506833 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65520 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 46.82 cM, cytoband E3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SCARB2, scavenger receptor class B member 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    SCARB2, scavenger receptor class B member 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AMRF, CD36L2, EPM4, HLGP85, LGP85, LIMP-2, LIMPII, SR-BII
  • Links
    NCBI Gene ID: 950
    neXtProt AC: NX_Q14108
    UniProt: Q14108

  • Chr Location
    4q21.1; chr4:76158737-76213899 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Scarb2 mouse models; 1 with human SCARB2 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 1 allele in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in renal dysfunction, progressive deafness, and progressive demylination of the peripheral nerves. Mutant animals show a 2-fold increased water consumption along with increased urine volume, and develop an enlarged, ball-like trunk with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000055604 VEGA Gene Model | MGI Sequence Detail 65520 C57BL/6J ±  kb
    transcript OTTMUST00000137618 VEGA | MGI Sequence Detail 4698 Not Applicable  
    polypeptide OTTMUSP00000072453 VEGA | MGI Sequence Detail 478 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      480 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2445131
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 26
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:255338 Zheng F, et al., CD36 Deficiency Suppresses Epileptic Seizures. Neuroscience. 2017 Dec 26;367:110-120

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory