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Klhl7
Gene Detail
Symbol

Name
ID
Klhl7
kelch-like 7
MGI:1196453
Synonyms
2700038B03Rik, D5Ertd363e, Klhl6, SBBI26
Feature Type
protein coding gene
Genetic Map
Chromosome 5
10.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:24100605-24160792 bp, + strand
From VEGA annotation of GRCm38

  60188 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KLHL7
Protein SuperFamily: kelch-like protein, gigaxonin type
Gene Tree: Klhl7

Human
homologs
KLHL7, kelch-like family member 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 55975
neXtProt AC: NX_Q8IXQ5

Human Synonyms: KLHL6, SBBI26

Human Chr (Location): 7p15.3; chr7:23105734-23175421 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KLHL7

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(15) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
Klhl7 interacts with 275 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process protein ubiquitination
Component Cul3-RING ubiquitin ligase complex, cytoplasm, ...
Function identical protein binding, protein homodimerization activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (84)    Tissues (13)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 84
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase klhl7    NEW 
Molecular
reagents
All nucleic(66) cDNA(65) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000053534 (Evidence)
Ensembl Gene Model ENSMUSG00000028986 (Evidence)
Entrez Gene 52323 (Evidence)
UniGene 273768
DFCI TC1575340, TC1603291, TC1608910, TC1618799, TC1726518
DoTS DT.492774, DT.91595968, DT.97343995, DT.97393407, DT.99840084
Consensus CDS Project CCDS19114.1, CCDS51432.1
International Mouse Phenotyping Consortium Status Klhl7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053534 VEGA Gene Model | MGI Sequence Detail 60188 C57BL/6J ±  kb
transcript OTTMUST00000133494 VEGA | MGI Sequence Detail 2966 Not Applicable 
polypeptide OTTMUSP00000070942 VEGA | MGI Sequence Detail 586 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(7) UniProt(4)
Polymorphisms
SNPs within 2kb(525 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011705 BTB/Kelch-associated
InterPro IPR017096 BTB-kelch protein
InterPro IPR000210 BTB/POZ domain
InterPro IPR015916 Galactose oxidase, beta-propeller
InterPro IPR030599 Kelch-like protein 7
InterPro IPR006652 Kelch repeat type 1
InterPro IPR015915 Kelch-type beta propeller
InterPro IPR011333 POZ domain
Protein Ontology PR:000009403 kelch-like protein 7
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(31)
Other
accession IDs
MGI:1915157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory