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Tnpo3 Gene Detail
Summary
  • Symbol
    Tnpo3
  • Name
    transportin 3
  • Synonyms
    5730544L10Rik, C430013M08Rik, D6Ertd313e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196412
    NCBI Gene: 320938
  • Gene Overview
    MyGene.info: TNPO3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29540827-29609887 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.36 cM, cytoband A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    161 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196412
protein coding gene Chr6:29540827-29610113 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030528
protein coding gene Chr6:27345421-27417131 (-)
A/J MGP_AJ_G0030501
protein coding gene Chr6:26182724-26252103 (-)
AKR/J MGP_AKRJ_G0030428
protein coding gene Chr6:27045557-27116800 (-)
BALB/cJ MGP_BALBcJ_G0030511
protein coding gene Chr6:26339933-26412907 (-)
C3H/HeJ MGP_C3HHeJ_G0030224
protein coding gene Chr6:27046073-27118944 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030965
protein coding gene Chr6:28126232-28200036 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028176
protein coding gene Chr6:24391860-24462584 (-)
CAST/EiJ MGP_CASTEiJ_G0029626
protein coding gene Chr6:26849816-26918470 (-)
CBA/J MGP_CBAJ_G0030202
protein coding gene Chr6:29186332-29263797 (-)
DBA/2J MGP_DBA2J_G0030346
protein coding gene Chr6:26130356-26200538 (-)
FVB/NJ MGP_FVBNJ_G0030300
protein coding gene Chr6:25884272-25954260 (-)
LP/J MGP_LPJ_G0030433
protein coding gene Chr6:27474718-27548786 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030336
protein coding gene Chr6:31687550-31761079 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030995
protein coding gene Chr6:26921113-26995516 (-)
PWK/PhJ MGP_PWKPhJ_G0029340
protein coding gene Chr6:25663352-25734017 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029176
protein coding gene Chr6:26642704-26712138 (-)
WSB/EiJ MGP_WSBEiJ_G0029702
protein coding gene Chr6:26892866-26963879 (-)



Homology
more
  • Human Ortholog
    TNPO3, transportin 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNPO3, transportin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPO12, LGMD1F, LGMDD2, MTR10A, TRNSR, TRN-SR, TRN-SR2
  • Links
    NCBI Gene ID: 23534
    neXtProt AC: NX_Q9Y5L0
    UniProt: Q9Y5L0

  • Chr Location
    7q32.1; chr7:128954180-129055173 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 40848
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TNPO3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TNPO3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000012535 Ensembl Gene Model | MGI Sequence Detail 69061 C57BL/6J ±  kb
transcript ENSMUST00000115251 Ensembl | MGI Sequence Detail 3989 Not Applicable  
polypeptide ENSMUSP00000110906 Ensembl | MGI Sequence Detail 929 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • InterPro Domains
    IPR011989 Armadillo-like helical
    IPR016024 Armadillo-type fold
    IPR013598 Exportin-1/Importin-beta-like
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1913907, MGI:2141765, MGI:2445081
References
more
  • Summaries
    All 34
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:240645 Iwanami N, et al., Forward Genetic Screens in Zebrafish Identify Pre-mRNA-Processing Pathways Regulating Early T Cell Development. Cell Rep. 2016 Nov 22;17(9):2259-2270

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory