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Dpagt1
Gene Detail
Symbol

Name
ID
Dpagt1
dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
MGI:1196396
Synonyms
Dpagt2, Gnpta, GPT
Feature Type
protein coding gene
Genetic Map
Chromosome 9
24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:44326845-44333600 bp, + strand
From Ensembl annotation of GRCm38

  6756 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1058  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase
Gene Tree: Dpagt1

Human
homologs
Human Homolog DPAGT1, dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
NCBI Gene ID 1798
neXtProt AC  NX_Q9H3H5
Human Synonyms  ALG7, CDG1J, CDG-Ij, CMSTA2, D11S366, DGPT, DPAGT, DPAGT2, G1PT, GPT, UAGT, UGAT
Human Chr (Location)  11q23.3; chr11:119096503-119102091 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human DPAGT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(16) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a disruption in this gene display an embryonic lethal phenotype due to widespread cell death.
 
Interactions
Dpagt1 interacts with 95 markers (Mir15a, Mir15b, Mir16-1, ...)
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(94)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(104) Genomic(10) cDNA(94)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032123 (Evidence)
Entrez Gene13478 (Evidence)
UniGene18353
DFCITC1576679, TC1587531
DoTSDT.110622782, DT.101393469, DT.490246
NIA Mouse Gene IndexU010381
EC2.7.8.15
Consensus CDS ProjectCCDS23104.1
International Mouse Knockout Project StatusDpagt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032123 Ensembl Gene Model | MGI Sequence Detail 6756 C57BL/6J ±  kb
transcript ENSMUST00000054708 Ensembl | MGI Sequence Detail 1905 Not Applicable 
polypeptide ENSMUSP00000056282 Ensembl | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(12) UniProt(3)
Polymorphisms
SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000715 Glycosyl transferase, family 4
Protein Ontology PR:000006643 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
References
(Earliest) J:47505 Varki A, et al., Demonstration of the heterozygous state for I-cell disease and pseudo-Hurler polydystrophy by assay of N-acetylglucosaminylphosphotransferase in white blood cells and fibroblasts. Am J Hum Genet. 1982 Sep;34(5):717-29
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(43)
Other
accession IDs
MGD-MRK-10207, MGI:2143209, MGI:95788

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory