Dpagt1
Gene Detail

Symbol Name ID

Dpagt1 dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) MGI:1196396

Synonyms

Dpagt2, Gnpta, GPT

Feature Type

protein coding gene

Genetic Map

Chromosome 9

24.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr9:44326845-44333600 bp, + strand From NCBI annotation of GRCm38   6756 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; hamster, Chinese    (Mammalian Orthology)
Comparative Map (Mouse/Human Dpagt1 ± 2 cM)

Protein SuperFamily: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase
Gene Tree: Dpagt1

Human ortholog

DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) NCBI Gene ID 1798
Human Synonyms: ALG7, CDG1J, CDG-Ij, CMSTA2, D11S366, DGPT, DPAGT, DPAGT2, G1PT, GPT, UAGT, UGAT
Human Chr11:118967213-118972785 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human DPAGT1 (2)

Alleles and phenotypes

All alleles(19) : Targeted(3) Gene trapped(16)
 

Mice homozygous for a disruption in this gene display an embryonic lethal phenotype due to widespread cell death.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	dolichol biosynthetic process, dolichol-linked oligosaccharide biosynthetic process, ...
Component	endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function	phospho-N-acetylmuramoyl-pentapeptide-transferase activity, transferase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(94)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(104) Genomic(10) cDNA(94)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032123 (Evidence)
Entrez Gene	13478 (Evidence)
UniGene	18353
DFCI	TC1576679, TC1587531
DoTS	DT.101393469, DT.110622782, DT.490246
NIA Mouse Gene Index	U010381
EC	2.7.8.15
Consensus CDS Project	CCDS23104.1
International Mouse Knockout Project Status	Dpagt1

Sequences

Length	Strain/Species
genomic	13478	NCBI Gene Model | MGI Sequence Detail	6756	C57BL/6J
transcript	NM_007875	RefSeq | MGI Sequence Detail	1920	FVB/N
polypeptide	P42867	UniProt | EBI | MGI Sequence Detail	410	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000715	Glycosyl transferase, family 4
Protein Ontology	PR:000006643	UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

Graphical View of Protein Domain Structure

References

(Earliest) J:47505 Varki A, et al., Demonstration of the heterozygous state for I-cell disease and pseudo-Hurler polydystrophy by assay of N-acetylglucosaminylphosphotransferase in white blood cells and fibroblasts. Am J Hum Genet. 1982 Sep;34(5):717-29
(Latest) J:142754 Hansen GM, et al., Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 2008 Oct;18(10):1670-9
All references(43)

Other accession IDs

MGD-MRK-10207, MGI:2143209, MGI:95788