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Habp2
Gene Detail
Symbol

Name
ID
Habp2
hyaluronic acid binding protein 2
MGI:1196378
Synonyms
FSAP, MGC:28705
Feature Type
protein coding gene
Genetic Map
Chromosome 19
51.79 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:56287137-56320822 bp, + strand
From VEGA annotation of GRCm38

  33686 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3050  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HABP2
Protein SuperFamily: hyaluronan-binding protein 2
Gene Tree: Habp2

Human
homologs
HABP2, hyaluronan binding protein 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3026
neXtProt AC: NX_Q14520

Human Synonyms: FSAP, HABP, HGFAL, PHBP

Human Chr (Location): 10q25.3; chr10:113550831-113589602 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HABP2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit decreased lethality but increased liver fibrosis, inflammation and injury following bile duct ligation.
 
Interactions
Habp2 interacts with 155 markers (Mir10b, Mir16-1, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process proteolysis
Component extracellular region
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (53)    Tissues (12)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 47
RT-PCR 6
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase habp2    NEW 
Molecular
reagents
All nucleic(51) cDNA(49) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000036781 (Evidence)
Ensembl Gene Model ENSMUSG00000025075 (Evidence)
Entrez Gene 226243 (Evidence)
UniGene 25791
DFCI TC1585448, TC1719759
DoTS DT.530002, DT.101371083, DT.87048700
NIA Mouse Gene Index U019595
EC 3.4.21.-
Consensus CDS Project CCDS50475.1
International Mouse Phenotyping Consortium Status Habp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036781 VEGA Gene Model | MGI Sequence Detail 33686 C57BL/6J ±  kb
transcript OTTMUST00000094397 VEGA | MGI Sequence Detail 2314 Not Applicable 
polypeptide OTTMUSP00000052484 VEGA | MGI Sequence Detail 554 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(8) UniProt(8)
Polymorphisms
SNPs within 2kb(279 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000008428 hyaluronan-binding protein 2
References
(Earliest) J:44782 Hashimoto K, et al., Cloning of the cDNA for a mouse homologue of human PHBP: a novel hyaluronan-binding protein. Biol Pharm Bull. 1997 Nov;20(11):1127-30
(Latest) J:217173 Lockhart MM, et al., Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction. Dev Biol. 2014 Dec 1;396(1):8-18
All references(31)
Other
accession IDs
MGI:2147471

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory