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Habp2 Gene Detail
Summary
  • Symbol
    Habp2
  • Name
    hyaluronic acid binding protein 2
  • Synonyms
    FSAP, MGC:28705
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196378
    NCBI Gene: 226243
  • Gene Overview
    MyGene.info: HABP2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:56287109-56320089 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 51.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    275 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196378
protein coding gene Chr19:56287109-56320822 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025261
protein coding gene Chr19:56621418-56659805 (+)
A/J MGP_AJ_G0025237
protein coding gene Chr19:53827324-53862595 (+)
AKR/J MGP_AKRJ_G0025206
protein coding gene Chr19:55521549-55561796 (+)
BALB/cJ MGP_BALBcJ_G0025232
protein coding gene Chr19:53912647-53950546 (+)
C3H/HeJ MGP_C3HHeJ_G0024992
protein coding gene Chr19:55761464-55800399 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025675
protein coding gene Chr19:57985205-58023847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023087
protein coding gene Chr19:52754405-52790031 (+)
CAST/EiJ MGP_CASTEiJ_G0024457
protein coding gene Chr19:55776377-55811184 (+)
CBA/J MGP_CBAJ_G0024972
protein coding gene Chr19:60852787-60898756 (+)
DBA/2J MGP_DBA2J_G0025104
protein coding gene Chr19:53623106-53656755 (+)
FVB/NJ MGP_FVBNJ_G0025065
protein coding gene Chr19:53327168-53360766 (+)
LP/J MGP_LPJ_G0025190
protein coding gene Chr19:56486965-56522059 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025098
protein coding gene Chr19:60170793-60206656 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025733
protein coding gene Chr19:55744214-55777804 (+)
PWK/PhJ MGP_PWKPhJ_G0024205
protein coding gene Chr19:53569147-53604591 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024008
protein coding gene Chr19:54412691-54450472 (+)
WSB/EiJ MGP_WSBEiJ_G0024527
protein coding gene Chr19:55866963-55903665 (+)



Homology
more
  • Human Ortholog
    HABP2, hyaluronan binding protein 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HABP2, hyaluronan binding protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FSAP, HABP, HGFAL, NMTC5, PHBP
  • Links
    NCBI Gene ID: 3026
    neXtProt AC: NX_Q14520
    UniProt: Q14520

  • Chr Location
    10q25.3; chr10:113550831-113589602 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human HABP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased lethality but increased liver fibrosis, inflammation and injury following bile duct ligation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226243 NCBI Gene Model | MGI Sequence Detail 32981 C57BL/6J ±  kb
    transcript NM_001329935 RefSeq | MGI Sequence Detail 2934 C57BL/6  
    polypeptide Q8K0D2 UniProt | EBI | MGI Sequence Detail 558 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 50
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147471
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 2
    • Earliest
      J:44782 Hashimoto K, et al., Cloning of the cDNA for a mouse homologue of human PHBP: a novel hyaluronan-binding protein. Biol Pharm Bull. 1997 Nov;20(11):1127-30
    • Latest
      J:238703 Muggenthaler MM, et al., Mutations in HYAL2, Encoding Hyaluronidase 2, Cause a Syndrome of Orofacial Clefting and Cor Triatriatum Sinister in Humans and Mice. PLoS Genet. 2017 Jan;13(1):e1006470

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory