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Ildr2 Gene Detail
Summary
  • Symbol
    Ildr2
  • Name
    immunoglobulin-like domain containing receptor 2
  • Synonyms
    2810478N18Rik, 3110063L10Rik, D1Ertd471e, Dbsm1, ENSMUSG00000040612, OTTMUSG00000021748
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196370
    NCBI Gene: 100039795
Location & Maps
more
  • Sequence Map
    Chr1:166254139-166316823 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      62685 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 73.61 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ILDR2, immunoglobulin like domain containing receptor 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ILDR2, immunoglobulin like domain containing receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    C1orf32, dJ782G3.1
  • Links
    NCBI Gene ID: 387597
    neXtProt AC: NX_Q71H61

  • Chr Location
    1q24.1; chr1:166913204-166989093 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 52388
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: ILDR2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • QTL
    2
  • Targeted
    1
  • Genomic Mutations
    2 involving Ildr2
  • Incidental Mutations
Mice homozygous for an ENU-induced stop mutation at threonine-87 display a reduced pancreatic beta-cell replication rate, decreased beta-cell mass, reduced insulin/glucose ratio in blood, impaired glucose tolerance, and persistent mild hypoinsulinemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021748 VEGA Gene Model | MGI Sequence Detail 62685 C57BL/6J ±  kb
transcript OTTMUST00000051617 VEGA | MGI Sequence Detail 8251 Not Applicable  
polypeptide OTTMUSP00000024332 VEGA | MGI Sequence Detail 661 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    634 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    cDNA 49
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1920058, MGI:1920459, MGI:2138362, MGI:3641863, MGI:3814221
References
more
  • Summaries
    All 28
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:54765 Bergstrom DE, et al., Genetic and physical mapping of the Dreher locus on mouse Chromosome 1. Genomics. 1999;59:291-9
  • Latest
    J:200231 Higashi T, et al., Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2--tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis. J Cell Sci. 2013 Feb 15;126(Pt 4):966-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory