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Ildr2 Gene Detail
Summary
  • Symbol
    Ildr2
  • Name
    immunoglobulin-like domain containing receptor 2
  • Synonyms
    2810478N18Rik, 3110063L10Rik, D1Ertd471e, Dbsm1, ENSMUSG00000040612, OTTMUSG00000021748
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196370
    NCBI Gene: 100039795
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:166254139-166316823 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 73.61 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    634 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196370
protein coding gene Chr1:166254060-166316832 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016703
protein coding gene Chr1:171773670-171840279 (+)
A/J MGP_AJ_G0016684
protein coding gene Chr1:164790507-164853049 (+)
AKR/J MGP_AKRJ_G0016650
protein coding gene Chr1:169757663-169820988 (+)
BALB/cJ MGP_BALBcJ_G0016645
protein coding gene Chr1:165259940-165322259 (+)
C3H/HeJ MGP_C3HHeJ_G0016469
protein coding gene Chr1:169975535-170036847 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017106
protein coding gene Chr1:177529810-177592939 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014815
protein coding gene Chr1:156649012-156711142 (+)
CAST/EiJ MGP_CASTEiJ_G0016049
protein coding gene Chr1:169568753-169634650 (+)
CBA/J MGP_CBAJ_G0016444
protein coding gene Chr1:183853200-183917272 (+)
DBA/2J MGP_DBA2J_G0016550
protein coding gene Chr1:163650271-163716589 (+)
FVB/NJ MGP_FVBNJ_G0016548
protein coding gene Chr1:162084660-162147554 (+)
LP/J MGP_LPJ_G0016621
protein coding gene Chr1:172859893-172923593 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016573
protein coding gene Chr1:191290281-191353610 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017142
protein coding gene Chr1:169620769-169683758 (+)
PWK/PhJ MGP_PWKPhJ_G0015835
protein coding gene Chr1:162861602-162951195 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015622
protein coding gene Chr1:168459011-168550463 (+)
WSB/EiJ MGP_WSBEiJ_G0016111
protein coding gene Chr1:169756294-169816292 (+)



Homology
more
  • Human Ortholog
    ILDR2, immunoglobulin like domain containing receptor 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ILDR2, immunoglobulin like domain containing receptor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C1orf32, dJ782G3.1
  • Links
    NCBI Gene ID: 387597
    neXtProt AC: NX_Q71H61
    UniProt: Q71H61

  • Chr Location
    1q24.1; chr1:166913204-166975324 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 52388
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ILDR2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced stop mutation at threonine-87 display a reduced pancreatic beta-cell replication rate, decreased beta-cell mass, reduced insulin/glucose ratio in blood, impaired glucose tolerance, and persistent mild hypoinsulinemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040612 Ensembl Gene Model | MGI Sequence Detail 62685 C57BL/6J ±  kb
    transcript ENSMUST00000111416 Ensembl | MGI Sequence Detail 8251 Not Applicable  
    polypeptide ENSMUSP00000107047 Ensembl | MGI Sequence Detail 661 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      cDNA 49
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1920058, MGI:1920459, MGI:2138362, MGI:3641863, MGI:3814221
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 3
      Gene Ontology 2
      Phenotypes 5
    • Earliest
      J:54765 Bergstrom DE, et al., Genetic and physical mapping of the Dreher locus on mouse Chromosome 1. Genomics. 1999;59:291-9
    • Latest
      J:262844 Millings EJ, et al., ILDR2 has a negligible role in hepatic steatosis. PLoS One. 2018;13(5):e0197548

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory