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Iqsec1 Gene Detail
Summary
  • Symbol
    Iqsec1
  • Name
    IQ motif and Sec7 domain 1
  • Synonyms
    BRAG2, cI-43, D6Ertd349e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196356
    NCBI Gene: 232227
  • Gene Overview
    MyGene.info: IQSEC1
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:90659596-90988458 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 40.16 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1896 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196356
protein coding gene Chr6:90656088-90988685 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031041
protein coding gene Chr6:92205639-92368312 (-)
A/J MGP_AJ_G0031009
protein coding gene Chr6:88692028-88849474 (-)
AKR/J MGP_AKRJ_G0030941
protein coding gene Chr6:91165294-91319377 (-)
BALB/cJ MGP_BALBcJ_G0031021
protein coding gene Chr6:88642753-88797148 (-)
C3H/HeJ MGP_C3HHeJ_G0030687
protein coding gene Chr6:93119728-93276389 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031480
protein coding gene Chr6:94626935-94784678 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028648
protein coding gene Chr6:86682616-86836672 (-)
CAST/EiJ MGP_CASTEiJ_G0030128
protein coding gene Chr6:91275284-91432083 (-)
CBA/J MGP_CBAJ_G0030707
protein coding gene Chr6:98155156-98313725 (-)
DBA/2J MGP_DBA2J_G0030860
protein coding gene Chr6:87883571-88043146 (-)
FVB/NJ MGP_FVBNJ_G0030814
protein coding gene Chr6:87089072-87244550 (-)
LP/J MGP_LPJ_G0030940
protein coding gene Chr6:92173488-92331871 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030848
protein coding gene Chr6:102232962-102397547 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031507
protein coding gene Chr6:91006520-91164546 (-)
PWK/PhJ MGP_PWKPhJ_G0029844
protein coding gene Chr6:86828700-86984185 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029673
protein coding gene Chr6:89910516-90069178 (-)
WSB/EiJ MGP_WSBEiJ_G0030212
protein coding gene Chr6:91469940-91628831 (-)



Homology
more
  • Human Ortholog
    IQSEC1, IQ motif and Sec7 domain 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IQSEC1, IQ motif and Sec7 domain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARFGEP100, ARF-GEP100, BRAG2, GEP100
  • Links
    NCBI Gene ID: 9922
    neXtProt AC: NX_Q6DN90
    UniProt: Q6DN90

  • Chr Location
    3p25.2-p25.1; chr3:12897043-13282998 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 82429
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: IQSEC1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neurons fail to exhibit mGluR- and NMDAR-mediated long term depression.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 232227 NCBI Gene Model | MGI Sequence Detail 328863 C57BL/6J ±  kb
transcript NM_001134384 RefSeq | MGI Sequence Detail 6490 C57BL/6  
polypeptide Q8R0S2 UniProt | EBI | MGI Sequence Detail 961 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR030737 IQ motif and SEC7 domain-containing protein 1
    IPR033742 IQ motif and SEC7 domain-containing protein, PH domain
    IPR000048 IQ motif, EF-hand binding site
    IPR011993 PH-like domain superfamily
    IPR023394 Sec7, C-terminal domain superfamily
    IPR000904 Sec7 domain
    IPR035999 Sec7 domain superfamily
Molecular
Reagents
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  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1930797, MGI:2446231
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:254651 Sakagami H, et al., BRAG2a, a Guanine Nucleotide Exchange Factor for Arf6, Is a Component of the Dystrophin-Associated Glycoprotein Complex at the Photoreceptor Terminal. Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3795-3803

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory