About   Help   FAQ
Hyal2
Gene Detail
Symbol

Name
ID
Hyal2
hyaluronoglucosaminidase 2
MGI:1196334
Feature Type
protein coding gene
Genetic Map
Chromosome 9
58.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:107567945-107572779 bp, + strand
From Ensembl annotation of GRCm38

  4835 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7776  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: hyaluronidase
Gene Tree: Hyal2

Human
homologs
Human Homolog HYAL2, hyaluronoglucosaminidase 2
NCBI Gene ID 8692
neXtProt AC  NX_Q12891
Human Synonyms  LUCA2
Human Chr (Location)  3p21.3; chr3:50317790-50322850 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit postnatal lethality, poor survival, craniofacial defects, and mild anemia.
 
Interactions
Hyal2 interacts with 50 markers (Mir15a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (154)    Tissues (116)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 101
RT-PCR 53
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(11) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000010047 (Evidence)
Entrez Gene15587 (Evidence)
DFCITC1723978, TC1593054, TC1577013
DoTSDT.101394896, DT.530945, DT.91312512
EC3.2.1.35
Consensus CDS ProjectCCDS23496.1
International Mouse Knockout Project StatusHyal2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000010047 Ensembl Gene Model | MGI Sequence Detail 4835 C57BL/6J ±  kb
transcript ENSMUST00000195752 Ensembl | MGI Sequence Detail 2062 Not Applicable 
polypeptide ENSMUSP00000141280 Ensembl | MGI Sequence Detail 473 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR017853 Glycoside hydrolase, superfamily
InterPro IPR018155 Hyaluronidase
Protein Ontology PR:000008848 hyaluronidase-2
References
(Earliest) J:50537 Strobl B, et al., Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Genomics. 1998 Oct 15;53(2):214-9
(Latest) J:193882 Chowdhury B, et al., Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction. J Biol Chem. 2013 Jan 4;288(1):520-8
All references(41)
Other
accession IDs
MGI:2143004, MGI:2143243, MGI:2143332

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory