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Hyal2 Gene Detail
Summary
  • Symbol
    Hyal2
  • Name
    hyaluronoglucosaminidase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196334
    NCBI Gene: 15587
  • Gene Overview
    MyGene.info: HYAL2
Location & Maps
more
  • Sequence Map
    Chr9:107567945-107572779 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4835 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 58.12 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    HYAL2, hyaluronoglucosaminidase 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    HYAL2, hyaluronoglucosaminidase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LUCA2
  • Links
    NCBI Gene ID: 8692
    neXtProt AC: NX_Q12891

  • Chr Location
    3p21.3; chr3:50317790-50322850 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    8
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit postnatal lethality, poor survival, craniofacial defects, and mild anemia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050817 VEGA Gene Model | MGI Sequence Detail 4835 C57BL/6J ±  kb
transcript OTTMUST00000128771 VEGA | MGI Sequence Detail 2062 Not Applicable  
polypeptide OTTMUSP00000069249 VEGA | MGI Sequence Detail 473 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    74 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 17
    Genomic 2
    cDNA 11
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
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MGI:2143004, MGI:2143243, MGI:2143332
References
more
  • Summaries
    All 41
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 7
  • Earliest
    J:50537 Strobl B, et al., Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Genomics. 1998 Oct 15;53(2):214-9
  • Latest
    J:218429 Modelski MJ, et al., Hyaluronidase 2: a novel germ cell hyaluronidase with epididymal expression and functional roles in mammalian sperm. Biol Reprod. 2014 Nov;91(5):109

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory