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Hyal2
Gene Detail
 Symbol
Name
ID
Hyal2
hyaluronoglucosaminidase 2
MGI:1196334
Feature Type protein coding gene
Genetic Map
Chromosome 9
58.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:107569163-107572778 bp, + strand
From NCBI annotation of GRCm38

  3616 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7776  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: hyaluronidase
Gene Tree: Hyal2

Human
homologs
Human Homolog HYAL2, hyaluronoglucosaminidase 2
NCBI Gene ID 8692
neXtProt AC  NX_Q12891
Human Synonyms  LUCA2
Human Chr (Location)  3p21.3; chr3:50317790-50322850 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit postnatal lethality, poor survival, craniofacial defects, and mild anemia.
 
Interactions
Hyal2 interacts with 50 markers (Mir15a, Mir24-1, Mir24-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (80 annotations)
Process carbohydrate metabolic process, cellular response to fibroblast growth factor stimulus, ...
Component anchored component of external side of plasma membrane, anchored component of membrane, ...
Function catalytic activity, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (154)    Tissues (116)    Images (9)
Theiler Stages: 10, 16, 18, 20, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 101
RT-PCR 53
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) Genomic(2) cDNA(11) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000010047 (Evidence)
Entrez Gene15587 (Evidence)
DFCITC1577013, TC1593054, TC1723978
DoTSDT.101394896, DT.530945, DT.91312512
EC3.2.1.35
Consensus CDS ProjectCCDS23496.1
International Mouse Knockout Project StatusHyal2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15587 NCBI Gene Model | MGI Sequence Detail 3616 C57BL/6J ±  kb
transcript NM_010489 RefSeq | MGI Sequence Detail 1872 CZECHII 
polypeptide O35632 UniProt | EBI | MGI Sequence Detail 473 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(58 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR017853 Glycoside hydrolase, superfamily
InterPro IPR018155 Hyaluronidase
Protein Ontology PR:000008848 hyaluronidase-2
Graphical View of Protein Domain Structure
References (Earliest) J:50537 Strobl B, et al., Structural organization and chromosomal localization of Hyal2, a gene encoding a lysosomal hyaluronidase. Genomics. 1998 Oct 15;53(2):214-9
(Latest) J:193882 Chowdhury B, et al., Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction. J Biol Chem. 2013 Jan 4;288(1):520-8
All references(41)
Other
accession IDs
MGI:2143004, MGI:2143243, MGI:2143332

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory