Arhgap6
Gene Detail

Symbol Name ID

Arhgap6 Rho GTPase activating protein 6 MGI:1196332

Synonyms

RhoGAPX-1

Feature Type

protein coding gene

Genetic Map

Chromosome X

78.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

ChrX:168795099-169304435 bp, + strand From VEGA annotation of GRCm38   509337 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7630  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Arhgap6

Human homologs

Human Homolog		ARHGAP6, Rho GTPase activating protein 6
NCBI Gene ID		395
neXtProt AC		NX_O43182
Human Synonyms		RHOGAP6, RHOGAPX-1
Human Chr (Location)		Xp22.3; chrX:11155663-11683821 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a targeted null mutation do not exhibit any observable abnormalities.

 
Human Diseases Modeled Using Mouse Arhgap6 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	actin filament organization, activation of phospholipase C activity, ...
Component	actin cytoskeleton, cytoplasm, ...
Function	GTPase activator activity, phospholipase activator activity, ...

External Resources: FuncBase

Expression

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(3) cDNA(27) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000019560 (Evidence)
Ensembl Gene Model	ENSMUSG00000031355 (Evidence)
Entrez Gene	11856 (Evidence)
UniGene	441810
DFCI	TC1575751, TC1592898, TC1594398, TC1698390
NIA Mouse Gene Index	U020407
Consensus CDS Project	CCDS30534.1, CCDS41212.1
International Mouse Knockout Project Status	Arhgap6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019560	VEGA Gene Model | MGI Sequence Detail	509337	C57BL/6J
transcript	OTTMUST00000046828	VEGA | MGI Sequence Detail	5510	Not Applicable
polypeptide	OTTMUSP00000021181	VEGA | MGI Sequence Detail	987	Not Applicable

All sequences(63) RefSeq(4) UniProt(8)

Polymorphisms

SNPs(1315 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000198	Rho GTPase-activating protein domain
InterPro	IPR008936	Rho GTPase activation protein
Protein Ontology	PR:000004239	rho GTPase-activating protein 6

References

(Earliest) J:44720 Schaefer L, et al., Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects. Genomics. 1997 Dec 1;46(2):268-77
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)

Other accession IDs

MGI:2147898