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Arhgap6
Gene Detail
Symbol

Name
ID
Arhgap6
Rho GTPase activating protein 6
MGI:1196332
Synonyms
RhoGAPX-1
Feature Type
protein coding gene
Genetic Map
Chromosome X
78.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:168795099-169304435 bp, + strand
From VEGA annotation of GRCm38

  509337 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7630  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARHGAP6
Gene Tree: Arhgap6

Human
homologs
ARHGAP6, Rho GTPase activating protein 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 395
neXtProt AC: NX_O43182

Human Synonyms: RHOGAP6, RHOGAPX-1

Human Chr (Location): Xp22.3; chrX:11137543-11665701 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a targeted null mutation do not exhibit any observable abnormalities.
 
Human Diseases Modeled in Mice Using Arhgap6 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Arhgap6 interacts with 365 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process actin filament organization, activation of phospholipase C activity, ...
Component actin cytoskeleton, cytoplasm
Function GTPase activator activity, phospholipase activator activity, ...
External Resources: FuncBase
Expression
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase arhgap6    NEW 
Molecular
reagents
All nucleic(32) Genomic(3) cDNA(27) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000019560 (Evidence)
Ensembl Gene Model ENSMUSG00000031355 (Evidence)
Entrez Gene 11856 (Evidence)
UniGene 441810
DFCI TC1592898, TC1575751, TC1698390, TC1594398
NIA Mouse Gene Index U020407
Consensus CDS Project CCDS30534.1, CCDS41212.1, CCDS72472.1
International Mouse Phenotyping Consortium Status Arhgap6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019560 VEGA Gene Model | MGI Sequence Detail 509337 C57BL/6J ±  kb
transcript OTTMUST00000046828 VEGA | MGI Sequence Detail 5510 Not Applicable 
polypeptide OTTMUSP00000021181 VEGA | MGI Sequence Detail 987 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(13) UniProt(8)
Polymorphisms
SNPs within 2kb(1368 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000004239 rho GTPase-activating protein 6
References
(Earliest) J:44720 Schaefer L, et al., Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects. Genomics. 1997 Dec 1;46(2):268-77
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(32)
Disease annotation references (1)
Other
accession IDs
MGI:2147898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory