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Arhgap6
Gene Detail
 Symbol
Name
ID
Arhgap6
Rho GTPase activating protein 6
MGI:1196332
Synonyms RhoGAPX-1
Feature Type protein coding gene
Genetic Map
Chromosome X
78.77 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
ChrX:168795099-169304435 bp, + strand
From VEGA annotation of GRCm38

  509337 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7630  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Arhgap6

Human
homologs
Human Homolog ARHGAP6, Rho GTPase activating protein 6
NCBI Gene ID 395
neXtProt AC  NX_O43182
Human Synonyms  RHOGAP6, RHOGAPX-1
Human Chr (Location)  Xp22.3; chrX:11137543-11665701 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted null mutation do not exhibit any observable abnormalities.
 
Human Diseases Modeled Using Mouse Arhgap6 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Arhgap6 interacts with 366 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process actin filament organization, activation of phospholipase C activity, ...
Component actin cytoskeleton, cytoplasm, ...
Function GTPase activator activity, phospholipase activator activity, ...
External Resources: FuncBase
Expression
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(3) cDNA(27) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019560 (Evidence)
Ensembl Gene ModelENSMUSG00000031355 (Evidence)
Entrez Gene11856 (Evidence)
UniGene441810
DFCITC1575751, TC1592898, TC1594398, TC1698390
NIA Mouse Gene IndexU020407
Consensus CDS ProjectCCDS30534.1, CCDS41212.1, CCDS72472.1
International Mouse Knockout Project StatusArhgap6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019560 VEGA Gene Model | MGI Sequence Detail 509337 C57BL/6J ±  kb
transcript OTTMUST00000046828 VEGA | MGI Sequence Detail 5510 Not Applicable 
polypeptide OTTMUSP00000021181 VEGA | MGI Sequence Detail 987 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(9) UniProt(8)
Polymorphisms SNPs within 2kb(1368 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
Protein Ontology PR:000004239 rho GTPase-activating protein 6
References (Earliest) J:44720 Schaefer L, et al., Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects. Genomics. 1997 Dec 1;46(2):268-77
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(33)
Other
accession IDs
MGI:2147898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory