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Arhgap6 Gene Detail
Summary
  • Symbol
    Arhgap6
  • Name
    Rho GTPase activating protein 6
  • Synonyms
    RhoGAPX-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196332
    NCBI Gene: 11856
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:168795099-169304435 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 78.77 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1361 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196332
protein coding gene ChrX:168795094-169304440 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036275
protein coding gene ChrX:167001653-167521738 (+)
A/J MGP_AJ_G0036245
protein coding gene ChrX:166131150-166635217 (+)
AKR/J MGP_AKRJ_G0036174
protein coding gene ChrX:171453277-171972138 (+)
BALB/cJ MGP_BALBcJ_G0036239
protein coding gene ChrX:164094309-164601691 (+)
C3H/HeJ MGP_C3HHeJ_G0035946
protein coding gene ChrX:167310955-167833201 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036762
protein coding gene ChrX:171848108-172365361 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033582
protein coding gene ChrX:156853276-157352164 (+)
CAST/EiJ MGP_CASTEiJ_G0035233
protein coding gene ChrX:146172821-146693456 (+)
CBA/J MGP_CBAJ_G0035920
protein coding gene ChrX:176848942-177373227 (+)
DBA/2J MGP_DBA2J_G0036086
protein coding gene ChrX:164895499-165410470 (+)
FVB/NJ MGP_FVBNJ_G0036018
protein coding gene ChrX:164036932-164538838 (+)
LP/J MGP_LPJ_G0036171
protein coding gene ChrX:168086607-168593425 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036050
protein coding gene ChrX:185578524-186135209 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036801
protein coding gene ChrX:166481731-167018465 (+)
PWK/PhJ MGP_PWKPhJ_G0034932
protein coding gene ChrX:142897832-143392204 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034751
protein coding gene ChrX:146755226-147290116 (+)
WSB/EiJ MGP_WSBEiJ_G0035369
protein coding gene ChrX:164275014-164787849 (+)



Homology
more
  • Human Ortholog
    ARHGAP6, Rho GTPase activating protein 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGAP6, Rho GTPase activating protein 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RHOGAP6, RHOGAPX-1
  • Links
    NCBI Gene ID: 395
    neXtProt AC: NX_O43182
    UniProt: O43182

  • Chr Location
    Xp22.2; chrX:11137543-11665701 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Arhgap6 mouse models

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation do not exhibit any observable abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031355 Ensembl Gene Model | MGI Sequence Detail 509337 C57BL/6J ±  kb
transcript ENSMUST00000033721 Ensembl | MGI Sequence Detail 5510 Not Applicable  
polypeptide ENSMUSP00000033721 Ensembl | MGI Sequence Detail 987 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR030772 Rho GTPase-activating protein 6
    IPR037863 Rho GTPase-activating protein 6/36
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
less
  • All nucleic 31
    Genomic 4
    cDNA 27

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147898
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:44720 Schaefer L, et al., Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects. Genomics. 1997 Dec 1;46(2):268-77
  • Latest
    J:222518 Yeung CY, et al., Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers. PLoS One. 2014;9(9):e107036

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory