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Arhgap6 Gene Detail
Summary
  • Symbol
    Arhgap6
  • Name
    Rho GTPase activating protein 6
  • Synonyms
    RhoGAPX-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196332
    NCBI Gene: 11856
Location & Maps
more
  • Sequence Map
    ChrX:168795099-169304435 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      509337 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ARHGAP6, Rho GTPase activating protein 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ARHGAP6, Rho GTPase activating protein 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RHOGAP6, RHOGAPX-1
  • Links
    NCBI Gene ID: 395
    neXtProt AC: NX_O43182

  • Chr Location
    Xp22.3; chrX:11137543-11665701 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Arhgap6 mouse models

Human Disease Mouse Models
       Linear Skin Defects with Multiple Congenital Anomalies 1; LSDMCA1   OMIM: 309801 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a targeted null mutation do not exhibit any observable abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019560 VEGA Gene Model | MGI Sequence Detail 509337 C57BL/6J ±  kb
transcript OTTMUST00000046828 VEGA | MGI Sequence Detail 5510 Not Applicable  
polypeptide OTTMUSP00000021181 VEGA | MGI Sequence Detail 987 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1361 from dbSNP Build 142
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR030772 Rho GTPase-activating protein 6
    IPR000198 Rho GTPase-activating protein domain
    IPR008936 Rho GTPase activation protein
Molecular
Reagents
less
  • All nucleic 32
    Genomic 3
    cDNA 27
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147898
References
more
  • Summaries
    All 30
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:44720 Schaefer L, et al., Cloning and characterization of a novel rho-type GTPase-activating protein gene (ARHGAP6) from the critical region for microphthalmia with linear skin defects. Genomics. 1997 Dec 1;46(2):268-77
  • Latest
    J:222518 Yeung CY, et al., Arhgap28 is a RhoGAP that inactivates RhoA and downregulates stress fibers. PLoS One. 2014;9(9):e107036

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory