Eif6 MGI Mouse Gene Detail - MGI:1196288 - eukaryotic translation initiation factor 6

Symbol

Eif6
Name

eukaryotic translation initiation factor 6
Synonyms

eIF6, imc-415, Itgb4bp, p27BBP

Feature Type

protein coding gene
IDs

MGI:1196288
NCBI Gene: 16418
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr2:155661757-155668845 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 77.26 cM
Mapping Data

2 experiments

SNPs within 2kb

271 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196288	protein coding gene	Chr2:155661752-155668845 (-)
129S1/SvImJ	ENSMUSG00200028427	protein coding gene	Chr2:152529890-152536884 (-)
A/J	ENSMUSG00195015902	protein coding gene	Chr2:152889792-152896884 (-)
AKR/J	ENSMUSG00220039820	protein coding gene	Chr2:152179225-152186318 (-)
BALB/cJ	ENSMUSG00180044132	protein coding gene	Chr2:152364847-152371853 (-)
C3H/HeJ	ENSMUSG00175047905	protein coding gene	Chr2:153115286-153122292 (-)
C57BL/6NJ	ENSMUSG00215035323	protein coding gene	Chr2:152509481-152516575 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024539	protein coding gene	Chr2:147779311-147785999 (-)
CAST/EiJ	ENSTCUG00005040694	protein coding gene	Chr2:151499433-151506546 (-)
CBA/J	ENSMUSG00210016456	protein coding gene	Chr2:153046392-153053398 (-)
DBA/2J	ENSMUSG00185042373	protein coding gene	Chr2:152722644-152729736 (-)
FVB/NJ	ENSMUSG00205041487	protein coding gene	Chr2:151802240-151809252 (-)
JF1/MsJ	ENSUMUG00000010559	protein coding gene	Chr2:152378838-152385931 (-)
LP/J	ENSMUSG00230041500	protein coding gene	Chr2:154327112-154334821 (-)
NOD/ShiLtJ	ENSMUSG00190044348	protein coding gene	Chr2:152434904-152441911 (-)
NZO/HlLtJ	ENSMUSG00225003031	protein coding gene	Chr2:162361760-162369474 (-)
PWK/PhJ	ENSLUMG00010040705	protein coding gene	Chr2:152320931-152328023 (-)
SPRET/EiJ	ENSMSPG00010029867	protein coding gene	Chr2:155120831-155127928 (-)
WSB/EiJ	ENSIUOG00005045793	protein coding gene	Chr2:152120189-152127203 (-)

Human Ortholog

EIF6, eukaryotic translation initiation factor 6

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EIF6, eukaryotic translation initiation factor 6
Synonyms

b(2)gcn, CAB, EIF3A, eIF-6, ITGB4BP, p27(BBP), p27BBP
Links

HGNC:6159

NCBI Gene ID: 3692

UniProt: P56537
Chr Location

20q11.22; chr20:35278906-35284985 (-) GRCh38

MGI Vertebrate Homology

Eif6 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: EIF6
Protein SuperFamily

IF-6
Gene Tree

Eif6

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Endonuclease-mediated

4
Gene trapped

10
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit lethality prior to E3.5 and mice heterozygous for the allele exhibit reduced body, liver and adipose tissue weights associated with a reduced translation rate and delayed G1/S phase transition.

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All GO Annotations

47
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

607
Tissues

4
cDNA Data

215
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eif6

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All Sequences

84
RefSeq

2
UniProt

11
CCDS

CCDS16956.1

Ensembl

ENSMUSG00000027613 (Evidence)
NCBI Gene

16418

			Length	Strain/Species	Flank
genomic	16418	NCBI Gene Model \| MGI Sequence Detail	7089	C57BL/6J	± kb
transcript	NM_010579	RefSeq \| MGI Sequence Detail	1495	C57BL/6
polypeptide	O55135	UniProt \| EBI \| MGI Sequence Detail	245	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000007007 eukaryotic translation initiation factor 6

(term hierarchy)
InterPro Domains

IPR002769 Translation initiation factor IF6
GlyGen

O55135 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 216

cDNA 216

Antibodies 1

Microarray probesets 5

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MGI:2138760

Summaries

All 61

Developmental Gene Expression 5

Gene Ontology 11

Phenotypes 19
Earliest

J:44335 Biffo S, et al., Isolation of a novel beta4 integrin-binding protein (p27(BBP)) highly expressed in epithelial cells. J Biol Chem. 1997 Nov 28;272(48):30314-21
Latest

J:376293 Miluzio A, et al., Recycling of ribosomes at stop codons drives the rate of translation and the transition from proliferation to RESt. Mol Cell. 2025 Dec 4;85(23):4410-4425.e11

TSS for Eif6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr27017	Chr2:155668567-155668630 (-)	246 bp
Tssr27016	Chr2:155668526-155668538 (-)	313 bp
Tssr27015	Chr2:155668385-155668401 (-)	452 bp
Tssr27014	Chr2:155668373-155668384 (-)	466 bp
Tssr714	Chr2:155668354-155668365 (-)	485 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24