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Dffb Gene Detail
Summary
  • Symbol
    Dffb
  • Name
    DNA fragmentation factor, beta subunit
  • Synonyms
    40kDa, 5730477D02Rik, CAD, caspase-activated DNase, CPAN, DFF40, Didff
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196287
    NCBI Gene: 13368
  • Gene Overview
    MyGene.info: DFFB
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:153964447-153975121 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.78 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    68 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196287
protein coding gene Chr4:153964447-153975126 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029186
protein coding gene Chr4:158196596-158207175 (-)
A/J MGP_AJ_G0029151
protein coding gene Chr4:151568705-151579359 (-)
AKR/J MGP_AKRJ_G0029099
protein coding gene Chr4:155698887-155709938 (-)
BALB/cJ MGP_BALBcJ_G0029167
protein coding gene Chr4:152034096-152044763 (-)
C3H/HeJ MGP_C3HHeJ_G0028888
protein coding gene Chr4:156234642-156245156 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029616
protein coding gene Chr4:163857847-163868463 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026862
protein coding gene Chr4:143868422-143879967 (-)
CAST/EiJ MGP_CASTEiJ_G0028301
protein coding gene Chr4:153631264-153641600 (-)
CBA/J MGP_CBAJ_G0028850
protein coding gene Chr4:168786025-168796679 (-)
DBA/2J MGP_DBA2J_G0028999
protein coding gene Chr4:151592715-151603668 (-)
FVB/NJ MGP_FVBNJ_G0028963
protein coding gene Chr4:150793492-150804259 (-)
LP/J MGP_LPJ_G0029089
protein coding gene Chr4:158112570-158123745 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028990
protein coding gene Chr4:171703089-171714792 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029648
protein coding gene Chr4:156265837-156276509 (-)
PWK/PhJ MGP_PWKPhJ_G0028021
protein coding gene Chr4:147669106-147679503 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027855
protein coding gene Chr4:150552061-150563427 (-)
WSB/EiJ MGP_WSBEiJ_G0028381
protein coding gene Chr4:156428421-156440592 (-)



Homology
more
  • Human Ortholog
    DFFB, DNA fragmentation factor subunit beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DFFB, DNA fragmentation factor subunit beta
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAD, CPAN, DFF2, DFF40, DFF-40
  • Links
    NCBI Gene ID: 1677
    neXtProt AC: NX_O76075
    UniProt: O76075

  • Chr Location
    1p36.32; chr1:3857143-3885429 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, fertile and developmentally normal; however, mutant thymocytes and other cell types fail to undergo apoptotic DNA fragmentation in response to dexamethasone or other apoptotic stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13368 NCBI Gene Model | MGI Sequence Detail 10675 C57BL/6J ±  kb
transcript NM_007859 RefSeq | MGI Sequence Detail 2073 C57BL/6  
polypeptide O54788 UniProt | EBI | MGI Sequence Detail 344 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 23

    Microarray probesets 5
Other
Accession IDs
less
MGI:2442077
References
more
  • Summaries
    All 59
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 22
  • Earliest
    J:45015 Enari M, et al., A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD [see comments]. Nature. 1998 Jan 1;391(6662):43-50
  • Latest
    J:259377 Gao L, et al., Novel role for caspase-activated DNase in the regulation of pathological cardiac hypertrophy. Hypertension. 2015 Apr;65(4):871-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory