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Dffb Gene Detail
Summary
  • Symbol
    Dffb
  • Name
    DNA fragmentation factor, beta subunit
  • Synonyms
    40kDa, 5730477D02Rik, CAD, caspase-activated DNase, CPAN, DFF40, Didff
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196287
    NCBI Gene: 13368
  • Gene Overview
    MyGene.info: DFFB
Location & Maps
more
  • Sequence Map
    Chr4:153964449-153975126 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10678 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 83.78 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DFFB, DNA fragmentation factor subunit beta
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DFFB, DNA fragmentation factor subunit beta
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CAD, CPAN, DFF2, DFF40, DFF-40
  • Links
    NCBI Gene ID: 1677
    neXtProt AC: NX_O76075

  • Chr Location
    1p36.3; chr1:3857143-3885429 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Gene trapped
    1
  • Targeted
    8
  • Genomic Mutations
    3 involving Dffb
  • Incidental Mutations
Mice homozygous for a knock-out allele are viable, fertile and developmentally normal; however, mutant thymocytes and other cell types fail to undergo apoptotic DNA fragmentation in response to dexamethasone or other apoptotic stimuli.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010511 VEGA Gene Model | MGI Sequence Detail 10678 C57BL/6J ±  kb
transcript OTTMUST00000024519 VEGA | MGI Sequence Detail 2093 Not Applicable  
polypeptide OTTMUSP00000011273 VEGA | MGI Sequence Detail 344 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    68 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    cDNA 22

    Microarray probesets 5
Other
Accession IDs
less
MGI:2442077
References
more
  • Summaries
    All 51
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 20
  • Earliest
    J:45015 Enari M, et al., A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD [see comments]. Nature. 1998 Jan 1;391(6662):43-50
  • Latest
    J:211019 Mizuta R, et al., DNase gamma is the effector endonuclease for internucleosomal DNA fragmentation in necrosis. PLoS One. 2013;8(12):e80223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory