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Tsc22d3
Gene Detail
Symbol

Name
ID
Tsc22d3
TSC22 domain family, member 3
MGI:1196284
Synonyms
Dsip1, Gilz
Feature Type
protein coding gene
Genetic Map
Chromosome X
61.35 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:140539528-140600659 bp, - strand
From VEGA annotation of GRCm38

  61132 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:104035  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: TSC22D3
Gene Tree: Tsc22d3

Human
homologs
TSC22D3, TSC22 domain family, member 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1831
neXtProt AC: NX_Q99576

Human Synonyms: DIP, DSIPI, GILZ, hDIP, TSC-22R

Human Chr (Location): Xq22.3; chrX:107713221-107777329 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice deficient for this gene display male sterility. Testes are severely reduced in size and weight and are devoid of germ cells in adults.
 
Interactions
Tsc22d3 interacts with 287 markers (Mir1b, Mir7-1, Mir7-2, ...)
Expression
Literature Summary: (8 records)
Data Summary: Results (77)    Tissues (62)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
RT-PCR 8
cDNA source data(109)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tsc22d3 ; ZFIN tsc22d3    NEW 
Molecular
reagents
All nucleic(110) cDNA(109) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000018845 (Evidence)
Ensembl Gene Model ENSMUSG00000031431 (Evidence)
Entrez Gene 14605 (Evidence)
UniGene 22216
DFCI TC1599916, TC1589724, TC1575868, TC1687438
DoTS DT.494893, DT.101382378, DT.94205404, DT.97406304
NIA Mouse Gene Index U039738
Consensus CDS Project CCDS30440.1, CCDS41150.1
International Mouse Phenotyping Consortium Status Tsc22d3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018845 VEGA Gene Model | MGI Sequence Detail 61132 C57BL/6J ±  kb
transcript OTTMUST00000045354 VEGA | MGI Sequence Detail 1552 Not Applicable 
polypeptide OTTMUSP00000020406 VEGA | MGI Sequence Detail 201 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(17) UniProt(2)
Polymorphisms
SNPs within 2kb(197 from dbSNP Build 137)    SNPs within 2kb including multiple locations(199)
Protein-related
information
ResourceIDDescription
InterPro IPR000580 TSC-22 / Dip / Bun
Protein Ontology PR:000016712 TSC22 domain family protein 3
References
(Earliest) J:45108 D'Adamio F, et al., A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity. 1997 Dec;7(6):803-12
(Latest) J:211820 Bereshchenko O, et al., GILZ promotes production of peripherally induced Treg cells and mediates the crosstalk between glucocorticoids and TGF-beta signaling. Cell Rep. 2014 Apr 24;7(2):464-75
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory