About   Help   FAQ
Tsc22d3
Gene Detail
 Symbol
Name
ID
Tsc22d3
TSC22 domain family, member 3
MGI:1196284
Synonyms Dsip1, Gilz
Feature Type protein coding gene
Genetic Map
Chromosome X
61.35 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:140539528-140600659 bp, - strand
From VEGA annotation of GRCm38

  61132 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:104035  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle

Gene Tree: Tsc22d3

Human
homologs
Human Homolog TSC22D3, TSC22 domain family, member 3
NCBI Gene ID 1831
neXtProt AC  NX_Q99576
Human Synonyms  DIP, DSIPI, GILZ, hDIP, TSC-22R
Human Chr (Location)  Xq22.3; chrX:107713221-107777329 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
 
Mice deficient for this gene display male sterility. Testes are severely reduced in size and weight and are devoid of germ cells in adults.
 
Interactions
Tsc22d3 interacts with 287 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process negative regulation of activation-induced cell death of T cells, negative regulation of skeletal muscle tissue development, ...
Component cytoplasm, nucleus
Function MRF binding, sequence-specific DNA binding transcription factor activity
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (77)    Tissues (62)    Images (11)
Theiler Stages: 2, 3, 4, 5, 17, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 69
RT-PCR 8
cDNA source data(109)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) cDNA(109) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018845 (Evidence)
Ensembl Gene ModelENSMUSG00000031431 (Evidence)
Entrez Gene14605 (Evidence)
UniGene22216
DFCITC1575868, TC1589724, TC1599916, TC1687438
DoTSDT.101382378, DT.494893, DT.94205404, DT.97406304
NIA Mouse Gene IndexU039738
Consensus CDS ProjectCCDS30440.1, CCDS41150.1
International Mouse Knockout Project StatusTsc22d3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018845 VEGA Gene Model | MGI Sequence Detail 61132 C57BL/6J ±  kb
transcript OTTMUST00000045354 VEGA | MGI Sequence Detail 1552 Not Applicable 
polypeptide OTTMUSP00000020406 VEGA | MGI Sequence Detail 201 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(19) UniProt(2)
Polymorphisms SNPs within 2kb(197 from dbSNP Build 137)    SNPs within 2kb including multiple locations(199)
Protein-related
information
ResourceIDDescription
InterPro IPR000580 TSC-22 / Dip / Bun
Protein Ontology PR:000016712 TSC22 domain family protein 3
References (Earliest) J:45108 D'Adamio F, et al., A new dexamethasone-induced gene of the leucine zipper family protects T lymphocytes from TCR/CD3-activated cell death. Immunity. 1997 Dec;7(6):803-12
(Latest) J:211820 Bereshchenko O, et al., GILZ promotes production of peripherally induced Treg cells and mediates the crosstalk between glucocorticoids and TGF-beta signaling. Cell Rep. 2014 Apr 24;7(2):464-75
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/16/2014
MGI 5.19
The Jackson Laboratory