Dscam
Gene Detail

Symbol Name ID

Dscam Down syndrome cell adhesion molecule MGI:1196281

Synonyms

4932410A21Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 16

57.02 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr16:96592079-97170752 bp, - strand From VEGA annotation of GRCm38   578674 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Dscam

Human homologs

Human Homolog		DSCAM, Down syndrome cell adhesion molecule
NCBI Gene ID		1826
neXtProt AC		NX_O60469
Human Synonyms		CHD2-42, CHD2-52
Human Chr (Location)		21q22.2; chr21:41384343-42219039 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(6) Gene trapped(1) Spontaneous(2)
 

Mice homozygous for a null allele exhibit background-sensitive perinatal lethality associated with respiratory distress, altered C4 ventral root and pre-inspiratory neuron signaling, and abnormal response to hypercapnia.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cell adhesion, dendrite morphogenesis, ...
Component	axon, growth cone, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (202)    Tissues (129)    Images (3)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	182
Western blot	2
RT-PCR	18

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(38) Genomic(3) cDNA(33) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017081 (Evidence)
Ensembl Gene Model	ENSMUSG00000050272 (Evidence)
Entrez Gene	13508 (Evidence)
UniGene	328737
DFCI	TC1583351
DoTS	DT.110728060, DT.40182994, DT.94230218
NIA Mouse Gene Index	U037346
Consensus CDS Project	CCDS37415.1
International Mouse Knockout Project Status	Dscam

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017081	VEGA Gene Model | MGI Sequence Detail	578674	C57BL/6J
transcript	OTTMUST00000041363	VEGA | MGI Sequence Detail	7498	Not Applicable
polypeptide	OTTMUSP00000018561	VEGA | MGI Sequence Detail	2013	Not Applicable

All sequences(21) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(2065 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000006695	down syndrome cell adhesion molecule

References

(Earliest) J:45496 Yamakawat K, et al., DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum Mol Genet. 1998 Feb;7(2):227-37
(Latest) J:192581 Maynard KR, et al., DSCAM contributes to dendrite arborization and spine formation in the developing cerebral cortex. J Neurosci. 2012 Nov 21;32(47):16637-50
All references(55)

Other accession IDs

MGI:1926011