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Dscam Gene Detail
Summary
  • Symbol
    Dscam
  • Name
    Down syndrome cell adhesion molecule
  • Synonyms
    4932410A21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196281
    NCBI Gene: 13508
Location & Maps
more
  • Sequence Map
    Chr16:96592079-97170752 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      578674 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DSCAM, Down syndrome cell adhesion molecule
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DSCAM, Down syndrome cell adhesion molecule
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CHD2, CHD2-42, CHD2-52
  • Links
    NCBI Gene ID: 1826
    neXtProt AC: NX_O60469

  • Chr Location
    21q22.2; chr21:40010999-40847113 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 74393
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DSCAM
  • Gene Tree
Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 6 alleles in 13 genetic backgrounds
    6 phenotypes from multigenic genotypes
    2 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Gene trapped
    1
  • Spontaneous
    3
  • Targeted
    9
  • Transgenic
    1
  • Genomic Mutations
    3 involving Dscam
  • Incidental Mutations
Mice homozygous for a null allele exhibit background-sensitive perinatal lethality associated with respiratory distress, altered C4 ventral root and pre-inspiratory neuron signaling, and abnormal response to hypercapnia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017081 VEGA Gene Model | MGI Sequence Detail 578674 C57BL/6J ±  kb
transcript OTTMUST00000041363 VEGA | MGI Sequence Detail 7498 Not Applicable  
polypeptide OTTMUSP00000018561 VEGA | MGI Sequence Detail 2013 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2151 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
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  • All nucleic 19
    Genomic 3
    cDNA 13
    Primer pair 2
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1926011
References
more
  • Summaries
    All 55
    Developmental Gene Expression 15
    Diseases 3
    Gene Ontology 7
    Phenotypes 34
  • Earliest
    J:45496 Yamakawat K, et al., DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum Mol Genet. 1998 Feb;7(2):227-37
  • Latest
    J:227617 Garrett AM, et al., Analysis of Expression Pattern and Genetic Deletion of Netrin5 in the Developing Mouse. Front Mol Neurosci. 2016;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory