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Dscam
Gene Detail
 Symbol
Name
ID
Dscam
Down syndrome cell adhesion molecule
MGI:1196281
Synonyms 4932410A21Rik
Feature Type protein coding gene
Genetic Map
Chromosome 16
57.02 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:96592079-97170752 bp, - strand
From VEGA annotation of GRCm38

  578674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74393  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Dscam

Human
homologs
Human Homolog DSCAM, Down syndrome cell adhesion molecule
NCBI Gene ID 1826
neXtProt AC  NX_O60469
Human Synonyms  CHD2, CHD2-42, CHD2-52
Human Chr (Location)  21q22.2; chr21:40012415-40847113 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Spontaneous(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit background-sensitive perinatal lethality associated with respiratory distress, altered C4 ventral root and pre-inspiratory neuron signaling, and abnormal response to hypercapnia.
 
Phenotype Images(2)
Interactions
Dscam interacts with 203 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell adhesion, dendrite morphogenesis, ...
Component axon, growth cone, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (204)    Tissues (134)    Images (3)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 184
Western blot 2
RT-PCR 18
cDNA source data(30)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(3) cDNA(31) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017081 (Evidence)
Ensembl Gene ModelENSMUSG00000050272 (Evidence)
Entrez Gene13508 (Evidence)
UniGene328737
DFCITC1583351
DoTSDT.110728060, DT.40182994, DT.94230218
NIA Mouse Gene IndexU037346
Consensus CDS ProjectCCDS37415.1
International Mouse Knockout Project StatusDscam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017081 VEGA Gene Model | MGI Sequence Detail 578674 C57BL/6J ±  kb
transcript OTTMUST00000041363 VEGA | MGI Sequence Detail 7498 Not Applicable 
polypeptide OTTMUSP00000018561 VEGA | MGI Sequence Detail 2013 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(2151 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2153)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000006695 down syndrome cell adhesion molecule
References (Earliest) J:45496 Yamakawat K, et al., DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system. Hum Mol Genet. 1998 Feb;7(2):227-37
(Latest) J:195831 Schramm RD, et al., A novel mouse Dscam mutation inhibits localization and shedding of DSCAM. PLoS One. 2012;7(12):e52652
All references(56)
Other
accession IDs
MGI:1926011

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory