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Klrd1 Gene Detail
Summary
  • Symbol
    Klrd1
  • Name
    killer cell lectin-like receptor, subfamily D, member 1
  • Synonyms
    CD94
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196275
    NCBI Gene: 16643
  • Gene Overview
    MyGene.info: KLRD1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:129591782-129598775 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.42 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196275
protein coding gene Chr6:129588092-129598775 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031353
protein coding gene Chr6:133261744-133271522 (+)
A/J MGP_AJ_G0031324
protein coding gene Chr6:128166919-128174283 (+)
AKR/J MGP_AKRJ_G0031252
protein coding gene Chr6:131665431-131673704 (+)
BALB/cJ MGP_BALBcJ_G0031331
protein coding gene Chr6:127815352-127822057 (+)
C3H/HeJ MGP_C3HHeJ_G0031055
protein coding gene Chr6:131862354-131869168 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031790
protein coding gene Chr6:136762984-136771260 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028936
protein coding gene Chr6:126488238-126495246 (+)
CAST/EiJ MGP_CASTEiJ_G0030433
protein coding gene Chr6:132099822-132107818 (+)
CBA/J MGP_CBAJ_G0031015
protein coding gene Chr6:142150666-142159834 (+)
DBA/2J MGP_DBA2J_G0031172
protein coding gene Chr6:127122517-127127884 (+)
FVB/NJ MGP_FVBNJ_G0031122
protein coding gene Chr6:126005425-126012230 (+)
LP/J MGP_LPJ_G0031252
protein coding gene Chr6:133484158-133490851 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031160
protein coding gene Chr6:145993689-146006122 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031823
protein coding gene Chr6:131736438-131746662 (+)
PWK/PhJ MGP_PWKPhJ_G0030151
protein coding gene Chr6:125398611-125408945 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029980
protein coding gene Chr6:129762475-129769169 (+)
WSB/EiJ MGP_WSBEiJ_G0030521
protein coding gene Chr6:132159026-132170436 (+)



Homology
more
  • Human Ortholog
    KLRD1, killer cell lectin like receptor D1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    KLRD1, killer cell lectin like receptor D1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD94
  • Links
    NCBI Gene ID: 3824
    neXtProt AC: NX_Q13241
    UniProt: Q13241

  • Chr Location
    12p13.2; chr12:10238385-10329607 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Mice homozygous for a knock-out allele exhibit normal NK cell function and susceptibillity to infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030165 Ensembl Gene Model | MGI Sequence Detail 6994 C57BL/6J ±  kb
transcript ENSMUST00000119520 Ensembl | MGI Sequence Detail 919 Not Applicable  
polypeptide ENSMUSP00000113399 Ensembl | MGI Sequence Detail 198 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
    IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
Molecular
Reagents
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  • All nucleic 38
    Genomic 6
    cDNA 31
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 44
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:45141 Vance RE, et al., Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur J Immunol. 1997 Dec;27(12):3236-41
  • Latest
    J:219208 Shin DL, et al., Segregation of a Spontaneous Klrd1 (CD94) Mutation in DBA/2 Mouse Substrains. G3 (Bethesda). 2014;5(2):235-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory