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Cdca8
Gene Detail
Symbol

Name
ID
Cdca8
cell division cycle associated 8
MGI:1196274
Synonyms
4831429J16Rik, Borealin, D4Ertd421e, DasraB
Feature Type
protein coding gene
Genetic Map
Chromosome 4
57.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:124918465-124939311 bp, - strand
From VEGA annotation of GRCm38

  20847 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Cdca8

Human
homologs
Human Homolog CDCA8, cell division cycle associated 8
NCBI Gene ID 55143
neXtProt AC  NX_Q53HL2
Human Synonyms  BOR, BOREALIN, DasraB, MESRGP
Human Chr (Location)  1p34.3; chr1:37692401-37709719 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit early embryonic lethality due to mitotic defects associated with abnormal microtubule organization and mislocalization of the chromosomal passenger protein complex. Blastocysts fail to develop past E3.5 and undergo apoptosis by E5.5.
 
Interactions
Cdca8 interacts with 83 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell cycle, cell division, ...
Component chromocenter, chromosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (6)    Tissues (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
cDNA source data(137)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) cDNA(138) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000009201 (Evidence)
Ensembl Gene ModelENSMUSG00000028873 (Evidence)
Entrez Gene52276 (Evidence)
UniGene28038
DFCITC1596320, TC1574083
DoTSDT.94188628, DT.87030161, DT.110805202, DT.101150636, DT.103564030
NIA Mouse Gene IndexU025510
Consensus CDS ProjectCCDS18631.1
International Mouse Knockout Project StatusCdca8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009201 VEGA Gene Model | MGI Sequence Detail 20847 C57BL/6J ±  kb
transcript OTTMUST00000020817 VEGA | MGI Sequence Detail 1264 Not Applicable 
polypeptide OTTMUSP00000009547 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(142 from dbSNP Build 137)    SNPs within 2kb including multiple locations(166)
Protein-related
information
ResourceIDDescription
InterPro IPR018851 Borealin-like, N-terminal
InterPro IPR018867 Cell division protein borealin
Protein Ontology PR:000005226 borealin
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)
Other
accession IDs
MGI:1915355, MGI:2140495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory