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Cdca8 Gene Detail
Summary
  • Symbol
    Cdca8
  • Name
    cell division cycle associated 8
  • Synonyms
    4831429J16Rik, Borealin, D4Ertd421e, DasraB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196274
    NCBI Gene: 52276
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:124812258-124830710 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 57.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196274
 protein coding gene Chr4:124812258-124833104 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028759
 protein coding gene Chr4:126486609-126506326 (-)
A/J MGP_AJ_G0028718
 protein coding gene Chr4:121519389-121538896 (-)
AKR/J MGP_AKRJ_G0028671
 protein coding gene Chr4:124844380-124863438 (-)
BALB/cJ MGP_BALBcJ_G0028741
 protein coding gene Chr4:122094871-122116279 (-)
C3H/HeJ MGP_C3HHeJ_G0028455
 protein coding gene Chr4:124928668-124949233 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029183
 protein coding gene Chr4:131350290-131370224 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026456
 protein coding gene Chr4:114689122-114709370 (-)
CAST/EiJ MGP_CASTEiJ_G0027888
 protein coding gene Chr4:123000434-123019498 (-)
CBA/J MGP_CBAJ_G0028421
 protein coding gene Chr4:134621154-134652617 (-)
DBA/2J MGP_DBA2J_G0028570
 protein coding gene Chr4:121992221-122012276 (-)
FVB/NJ MGP_FVBNJ_G0028537
 protein coding gene Chr4:120619977-120640213 (-)
LP/J MGP_LPJ_G0028671
 protein coding gene Chr4:126777195-126799085 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028563
 protein coding gene Chr4:139604889-139624057 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029221
 protein coding gene Chr4:125207317-125227971 (-)
PWK/PhJ MGP_PWKPhJ_G0027609
 protein coding gene Chr4:118418240-118437377 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027435
 protein coding gene Chr4:120980615-121000072 (-)
WSB/EiJ MGP_WSBEiJ_G0027968
 protein coding gene Chr4:125283157-125303415 (-)



Homology
more
  • Human Ortholog
    CDCA8, cell division cycle associated 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDCA8, cell division cycle associated 8
  • Synonyms
    BOR, BOREALIN, DasraB, MESRGP
  • Links
    NCBI Gene ID: 55143
    neXtProt AC: NX_Q53HL2
    UniProt: Q53HL2

  • Chr Location
    1p34.3; chr1:37692481-37709719 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit early embryonic lethality due to mitotic defects associated with abnormal microtubule organization and mislocalization of the chromosomal passenger protein complex. Blastocysts fail to develop past E3.5 and undergo apoptosis by E5.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    40
  • cDNA Data
    141
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52276 NCBI Gene Model | MGI Sequence Detail 18453 C57BL/6J ±  kb
    transcript NM_026560 RefSeq | MGI Sequence Detail 1626 ZRU/MplStud  
    polypeptide Q8BHX3 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      cDNA 142
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915355, MGI:2140495
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:342610 Didier-Mathon H, et al., Borealin/CDCA8 deficiency alters thyroid development and results in papillary tumor-like structures. Front Endocrinol (Lausanne). 2023;14:1286747
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory