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Cdca8
Gene Detail
Symbol

Name
ID
Cdca8
cell division cycle associated 8
MGI:1196274
Synonyms
4831429J16Rik, Borealin, D4Ertd421e, DasraB
Feature Type
protein coding gene
Genetic Map
Chromosome 4
57.93 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:124918465-124939311 bp, - strand
From VEGA annotation of GRCm38

  20847 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23075  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CDCA8
Gene Tree: Cdca8

Human
homologs
CDCA8, cell division cycle associated 8
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55143
neXtProt AC: NX_Q53HL2

Human Synonyms: BOR, BOREALIN, DasraB, MESRGP

Human Chr (Location): 1p34.3; chr1:37692401-37709719 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(12) Targeted(3)
Genomic Mutations involving Cdca8 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a reporter allele exhibit early embryonic lethality due to mitotic defects associated with abnormal microtubule organization and mislocalization of the chromosomal passenger protein complex. Blastocysts fail to develop past E3.5 and undergo apoptosis by E5.5.
 
Interactions
Cdca8 interacts with 83 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell cycle, cell division, ...
Component chromocenter, chromosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (43)    Tissues (27)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 10
In situ reporter (knock in) 3
Northern blot 20
Western blot 10
cDNA source data(138)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cdca8 ; ZFIN cdca8    NEW 
Molecular
reagents
All nucleic(141) cDNA(139) Primer pair(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000009201 (Evidence)
Ensembl Gene Model ENSMUSG00000028873 (Evidence)
Entrez Gene 52276 (Evidence)
UniGene 28038
DFCI TC1574083, TC1596320
DoTS DT.110805202, DT.103564030, DT.101150636, DT.94188628, DT.87030161
NIA Mouse Gene Index U025510
Consensus CDS Project CCDS18631.1
International Mouse Phenotyping Consortium Status Cdca8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009201 VEGA Gene Model | MGI Sequence Detail 20847 C57BL/6J ±  kb
transcript OTTMUST00000020817 VEGA | MGI Sequence Detail 1264 Not Applicable 
polypeptide OTTMUSP00000009547 VEGA | MGI Sequence Detail 326 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(142 from dbSNP Build 137)    SNPs within 2kb including multiple locations(166)
Protein-related
information
ResourceIDDescription
InterPro IPR018851 Borealin-like, N-terminal
InterPro IPR018867 Cell division protein borealin
Protein Ontology PR:000005226 borealin
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(39)
Other
accession IDs
MGI:1915355, MGI:2140495

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory