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Cdca8 Gene Detail
Summary
  • Symbol
    Cdca8
  • Name
    cell division cycle associated 8
  • Synonyms
    4831429J16Rik, Borealin, D4Ertd421e, DasraB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196274
    NCBI Gene: 52276
  • Gene Overview
    MyGene.info: CDCA8
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:124918465-124936917 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 57.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196274
protein coding gene Chr4:124918465-124939311 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028759
protein coding gene Chr4:126486609-126506326 (-)
A/J MGP_AJ_G0028718
protein coding gene Chr4:121519389-121538896 (-)
AKR/J MGP_AKRJ_G0028671
protein coding gene Chr4:124844380-124863438 (-)
BALB/cJ MGP_BALBcJ_G0028741
protein coding gene Chr4:122094871-122116279 (-)
C3H/HeJ MGP_C3HHeJ_G0028455
protein coding gene Chr4:124928668-124949233 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029183
protein coding gene Chr4:131350290-131370224 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026456
protein coding gene Chr4:114689122-114709370 (-)
CAST/EiJ MGP_CASTEiJ_G0027888
protein coding gene Chr4:123000434-123019498 (-)
CBA/J MGP_CBAJ_G0028421
protein coding gene Chr4:134621154-134652617 (-)
DBA/2J MGP_DBA2J_G0028570
protein coding gene Chr4:121992221-122012276 (-)
FVB/NJ MGP_FVBNJ_G0028537
protein coding gene Chr4:120619977-120640213 (-)
LP/J MGP_LPJ_G0028671
protein coding gene Chr4:126777195-126799085 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028563
protein coding gene Chr4:139604889-139624057 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029221
protein coding gene Chr4:125207317-125227971 (-)
PWK/PhJ MGP_PWKPhJ_G0027609
protein coding gene Chr4:118418240-118437377 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027435
protein coding gene Chr4:120980615-121000072 (-)
WSB/EiJ MGP_WSBEiJ_G0027968
protein coding gene Chr4:125283157-125303415 (-)



Homology
more
  • Human Ortholog
    CDCA8, cell division cycle associated 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CDCA8, cell division cycle associated 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BOR, BOREALIN, DasraB, MESRGP
  • Links
    NCBI Gene ID: 55143
    neXtProt AC: NX_Q53HL2
    UniProt: Q53HL2

  • Chr Location
    1p34.3; chr1:37692401-37709719 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit early embryonic lethality due to mitotic defects associated with abnormal microtubule organization and mislocalization of the chromosomal passenger protein complex. Blastocysts fail to develop past E3.5 and undergo apoptosis by E5.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52276 NCBI Gene Model | MGI Sequence Detail 18453 C57BL/6J ±  kb
    transcript NM_026560 RefSeq | MGI Sequence Detail 1626 C57BL/6  
    polypeptide Q8BHX3 UniProt | EBI | MGI Sequence Detail 289 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 142
      cDNA 140
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1915355, MGI:2140495
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:241850 Naiman N, et al., Repression of Interstitial Identity in Nephron Progenitor Cells by Pax2 Establishes the Nephron-Interstitium Boundary during Kidney Development. Dev Cell. 2017 May 22;41(4):349-365.e3

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory