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Casz1 Gene Detail
Summary
  • Symbol
    Casz1
  • Name
    castor zinc finger 1
  • Synonyms
    2410019P08Rik, castor, Cst, D4Ertd432e, MGC:31683
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196251
    NCBI Gene: 69743
  • Gene Overview
    MyGene.info: CASZ1
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:148804429-148954889 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.87 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1087 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196251
protein coding gene Chr4:148804367-148954893 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029131
protein coding gene Chr4:152574411-152736394 (+)
A/J MGP_AJ_G0029096
protein coding gene Chr4:146246940-146395836 (+)
AKR/J MGP_AKRJ_G0029044
protein coding gene Chr4:150235905-150396589 (+)
BALB/cJ MGP_BALBcJ_G0029112
protein coding gene Chr4:146747635-146904549 (+)
C3H/HeJ MGP_C3HHeJ_G0028833
protein coding gene Chr4:150798446-150953903 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029561
protein coding gene Chr4:158099498-158266675 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026807
protein coding gene Chr4:138661534-138818322 (+)
CAST/EiJ MGP_CASTEiJ_G0028246
protein coding gene Chr4:148009021-148172913 (+)
CBA/J MGP_CBAJ_G0028795
protein coding gene Chr4:162728197-162900153 (+)
DBA/2J MGP_DBA2J_G0028944
protein coding gene Chr4:146353011-146505119 (+)
FVB/NJ MGP_FVBNJ_G0028908
protein coding gene Chr4:145454636-145611353 (+)
LP/J MGP_LPJ_G0029034
protein coding gene Chr4:152533237-152693762 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028935
protein coding gene Chr4:166006075-166163657 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029593
protein coding gene Chr4:150735382-150891022 (+)
PWK/PhJ MGP_PWKPhJ_G0027966
protein coding gene Chr4:142345972-142500602 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027800
protein coding gene Chr4:144976514-145132861 (+)
WSB/EiJ MGP_WSBEiJ_G0028326
protein coding gene Chr4:150890172-151051280 (+)



Homology
more
  • Human Ortholog
    CASZ1, castor zinc finger 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CASZ1, castor zinc finger 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAS11, CST, dJ734G22.1, SRG, ZNF693
  • Links
    NCBI Gene ID: 54897
    neXtProt AC: NX_Q86V15
    UniProt: Q86V15

  • Chr Location
    1p36.22; chr1:10636602-10796676 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9824
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CASZ1
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Casz1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 4 alleles in 6 genetic backgrounds
    7 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit complete lethality throughout fetal growth and development and abnormal heart development associated with edema, decreased fetal cardiomyocyte proliferation, myocardium hypoplasia, ventricular septal defect, and altered heart shape and Z line formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028977 Ensembl Gene Model | MGI Sequence Detail 150461 C57BL/6J ±  kb
    transcript ENSMUST00000122222 Ensembl | MGI Sequence Detail 7926 Not Applicable  
    polypeptide ENSMUSP00000112978 Ensembl | MGI Sequence Detail 1762 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 44
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916993, MGI:2140527, MGI:2673697, MGI:3039630
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:264450 Mattar P, et al., Casz1 controls higher-order nuclear organization in rod photoreceptors. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7987-E7996

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory