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Dffa
Gene Detail
Symbol

Name
ID
Dffa
DNA fragmentation factor, alpha subunit
MGI:1196227
Synonyms
A330085O09Rik, DFF35, Dff45, ICAD-L, ICAD-S
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:149104146-149120647 bp, + strand
From VEGA annotation of GRCm38

  16502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3240  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA fragmentation factor, alpha subunit
Gene Tree: Dffa

Human
homologs
Human Homolog DFFA, DNA fragmentation factor, 45kDa, alpha polypeptide
NCBI Gene ID 1676
neXtProt AC  NX_O00273
Human Synonyms  DFF1, DFF-45, ICAD
Human Chr (Location)  1p36.3-p36.2; chr1:10460531-10472556 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
 
Mice homozygous for a knock-out allele show increased resistance to apoptosis in response to several apoptotic stimuli, enhanced spatial learning and memory, higher granule cell density and total granule cell number in the dentate gyrus, and resistance to kainic acid-induced CA3 neuronal cell death.
 
Interactions
Dffa interacts with 188 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic process, negative regulation of apoptotic DNA fragmentation, ...
Component cytoplasm, cytosol, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (10)    Tissues (10)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 10
cDNA source data(47)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(47) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010959 (Evidence)
Ensembl Gene ModelENSMUSG00000028974 (Evidence)
Entrez Gene13347 (Evidence)
UniGene41433
DFCITC1578327, TC1589173, TC1668284
DoTSDT.101209608, DT.101400866, DT.101708140, DT.492281, DT.91301893
NIA Mouse Gene IndexU005097
PDB1F2R
Consensus CDS ProjectCCDS18951.1, CCDS18952.1
International Mouse Knockout Project StatusDffa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010959 VEGA Gene Model | MGI Sequence Detail 16502 C57BL/6J ±  kb
transcript OTTMUST00000025709 VEGA | MGI Sequence Detail 2457 Not Applicable 
polypeptide OTTMUSP00000011788 VEGA | MGI Sequence Detail 331 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(5) UniProt(3)
Polymorphisms
SNPs within 2kb(201 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003508 Caspase-activated nuclease CIDE-N
InterPro IPR027296 DNA fragmentation factor 45kDa C-terminal domain
InterPro IPR015121 DNA fragmentation factor 45kDa, middle domain
InterPro IPR017299 DNA fragmentation factor, alpha subunit
Protein Ontology PR:000002188 DNA fragmentation factor subunit alpha
References
(Earliest) J:45015 Enari M, et al., A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD [see comments]. Nature. 1998 Jan 1;391(6662):43-50
(Latest) J:198289 Errami Y, et al., ICAD deficiency in human colon cancer and predisposition to colon tumorigenesis: linkage to apoptosis resistance and genomic instability. PLoS One. 2013;8(2):e57871
All references(50)
Other
accession IDs
MGI:2443522

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory