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Prag1 Gene Detail
Summary
  • Symbol
    Prag1
  • Name
    PEAK1 related kinase activating pseudokinase 1
  • Synonyms
    D8Ertd82e, NACK
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196223
    NCBI Gene: 244418
Location & Maps
more
  • Sequence Map
    Chr8:36094828-36147787 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52960 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 22.78 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PRAG1, PEAK1 related kinase activating pseudokinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRAG1, PEAK1 related kinase activating pseudokinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NACK, PEAK2, PRAGMIN, SGK223
  • Links
    NCBI Gene ID: 157285
    neXtProt AC: NX_Q86YV5

  • Chr Location
    8p23.1; chr8:8317736-8386443 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene leads to complete embryonic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022666 VEGA Gene Model | MGI Sequence Detail 52960 C57BL/6J ±  kb
transcript OTTMUST00000054307 VEGA | MGI Sequence Detail 4780 Not Applicable  
polypeptide OTTMUSP00000025906 VEGA | MGI Sequence Detail 1373 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    691 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 31
    cDNA 29
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:214228 Weaver KL, et al., NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis. Cancer Res. 2014 Sep 1;74(17):4741-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory