About   Help   FAQ
Terf2 Gene Detail
Summary
  • Symbol
    Terf2
  • Name
    telomeric repeat binding factor 2
  • Synonyms
    TRF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195972
    NCBI Gene: 21750
  • Gene Overview
    MyGene.info: TERF2
Location & Maps
more
  • Sequence Map
    Chr8:107069400-107096547 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27148 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 53.59 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TERF2, telomeric repeat binding factor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TERF2, telomeric repeat binding factor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TRBF2, TRF2
  • Links
    NCBI Gene ID: 7014
    neXtProt AC: NX_Q15554

  • Chr Location
    16q22.1; chr16:69355561-69386000 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    15
  • Targeted
    5
  • Incidental Mutations
Homozygous null mice display embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032784 VEGA Gene Model | MGI Sequence Detail 27148 C57BL/6J ±  kb
transcript OTTMUST00000081635 VEGA | MGI Sequence Detail 2666 Not Applicable  
polypeptide OTTMUSP00000043701 VEGA | MGI Sequence Detail 540 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    53 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016236 telomeric repeat-binding factor 2
  • InterPro Domains
    IPR009057 Homeodomain-like
    IPR017930 Myb domain
    IPR001005 SANT/Myb domain
    IPR013867 Telomere repeat-binding factor, dimerisation domain
    IPR030657 Telomeric repeat-binding factor 2
    IPR031902 Telomeric repeat-binding factor 2, Rap1-binding domain
Molecular
Reagents
less
  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 66
    Developmental Gene Expression 4
    Gene Ontology 15
    Phenotypes 18
  • Earliest
    J:43202 Broccoli D, et al., Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet. 1997 Oct;17(2):231-5
  • Latest
    J:228023 Zhang P, et al., Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity. Nat Commun. 2015;6:8888

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory