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Mr1
Gene Detail
Symbol

Name
ID
Mr1
major histocompatibility complex, class I-related
MGI:1195463
Synonyms
H2ls, MR1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
66.45 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:155127277-155146814 bp, - strand
From VEGA annotation of GRCm38

  19538 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123981  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: MR1
Gene Tree: Mr1

Human
homologs
MR1, major histocompatibility complex, class I-related
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3140
neXtProt AC: NX_Q95460

Human Synonyms: HLALS

Human Chr (Location): 1q25.3; chr1:181033379-181061938 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Null homozyogtes lack mucosal-associated invariant T cells that express the canonical mVa19-Ja33 rearrangement of the Tcra gene.
 
Interactions
Mr1 interacts with 193 markers (Mir7-1, Mir10b, Mir17, ...)
Gene Ontology
(GO)
classifications
Expression
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mr1    NEW 
Molecular
reagents
All nucleic(28) Genomic(5) cDNA(23)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000049823 (Evidence)
Ensembl Gene Model ENSMUSG00000026471 (Evidence)
Entrez Gene 15064 (Evidence)
UniGene 7580
DFCI TC1581673
DoTS DT.101365155, DT.40153506, DT.40177831, DT.91556766, DT.94214245
NIA Mouse Gene Index U021915
Consensus CDS Project CCDS15383.1
International Mouse Phenotyping Consortium Status Mr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049823 VEGA Gene Model | MGI Sequence Detail 19538 C57BL/6J ±  kb
transcript OTTMUST00000126883 VEGA | MGI Sequence Detail 2512 Not Applicable 
polypeptide OTTMUSP00000068579 VEGA | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(219 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR027648 MHC class I alpha chain
InterPro IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
InterPro IPR011161 MHC class I-like antigen recognition-like
Protein Ontology PR:000001819 MHC class I-related gene protein
References
(Earliest) J:43255 Yamaguchi H, et al., A highly conserved major histocompatibility complex class I-related gene in mammals. Biochem Biophys Res Commun. 1997 Sep 29;238(3):697-702
(Latest) J:207116 Seach N, et al., Double-positive thymocytes select mucosal-associated invariant T cells. J Immunol. 2013 Dec 15;191(12):6002-9
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory