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Mr1
Gene Detail
 Symbol
Name
ID
Mr1
major histocompatibility complex, class I-related
MGI:1195463
Synonyms H2ls, MR1
Feature Type protein coding gene
Genetic Map
Chromosome 1
66.45 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:155127878-155146780 bp, - strand
From NCBI annotation of GRCm38

  18903 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:123981  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Mr1

Human
homologs
Human Homolog MR1, major histocompatibility complex, class I-related
NCBI Gene ID 3140
neXtProt AC  NX_Q95460
Human Synonyms  HLALS
Human Chr (Location)  1q25.3; chr1:181033379-181061938 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Null homozyogtes lack mucosal-associated invariant T cells that express the canonical mVa19-Ja33 rearrangement of the Tcra gene.
 
Interactions
Mr1 interacts with 194 markers (Mir7-1, Mir10b, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process antigen processing and presentation, antigen processing and presentation of peptide antigen via MHC class I, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function antigen binding, peptide antigen binding
External Resources: FuncBase
Expression
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(5) cDNA(23)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000026471 (Evidence)
Entrez Gene15064 (Evidence)
UniGene7580
DFCITC1581673
DoTSDT.101365155, DT.40153506, DT.40177831, DT.91556766, DT.94214245
NIA Mouse Gene IndexU021915
Consensus CDS ProjectCCDS15383.1
International Mouse Knockout Project StatusMr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 15064 NCBI Gene Model | MGI Sequence Detail 18903 C57BL/6J ±  kb
transcript NM_008209 RefSeq | MGI Sequence Detail 2509 C57BL/6 
polypeptide Q8HWB0 UniProt | EBI | MGI Sequence Detail 341 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(214 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR011162 MHC classes I/II-like antigen recognition protein
InterPro IPR001039 MHC class I, alpha chain, alpha1/alpha2
InterPro IPR011161 MHC class I-like antigen recognition
Protein Ontology PR:000001819 MHC class I-related gene protein
Graphical View of Protein Domain Structure
References (Earliest) J:43255 Yamaguchi H, et al., A highly conserved major histocompatibility complex class I-related gene in mammals. Biochem Biophys Res Commun. 1997 Sep 29;238(3):697-702
(Latest) J:207116 Seach N, et al., Double-positive thymocytes select mucosal-associated invariant T cells. J Immunol. 2013 Dec 15;191(12):6002-9
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory