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Mr1 Gene Detail
Summary
  • Symbol
    Mr1
  • Name
    major histocompatibility complex, class I-related
  • Synonyms
    H2ls, MR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195463
    NCBI Gene: 15064
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:155127872-155146813 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 66.45 cM, cytoband H1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    215 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195463
protein coding gene Chr1:155127277-155146814 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016610
protein coding gene Chr1:160029069-160051091 (-)
A/J MGP_AJ_G0016591
protein coding gene Chr1:153607835-153627334 (-)
AKR/J MGP_AKRJ_G0016557
protein coding gene Chr1:158331683-158351128 (-)
BALB/cJ MGP_BALBcJ_G0016552
protein coding gene Chr1:154119864-154139618 (-)
C3H/HeJ MGP_C3HHeJ_G0016376
protein coding gene Chr1:158458540-158479050 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017013
protein coding gene Chr1:165545219-165564443 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014722
protein coding gene Chr1:145833404-145853107 (-)
CAST/EiJ MGP_CASTEiJ_G0015956
protein coding gene Chr1:157974415-157994915 (-)
CBA/J MGP_CBAJ_G0016351
protein coding gene Chr1:171387228-171406628 (-)
DBA/2J MGP_DBA2J_G0016457
protein coding gene Chr1:152585054-152604533 (-)
FVB/NJ MGP_FVBNJ_G0016455
protein coding gene Chr1:151053346-151072718 (-)
LP/J MGP_LPJ_G0016528
protein coding gene Chr1:161179490-161202596 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016480
protein coding gene Chr1:178967003-178986458 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017049
protein coding gene Chr1:158136909-158157435 (-)
PWK/PhJ MGP_PWKPhJ_G0015742
protein coding gene Chr1:151651405-151671089 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015529
protein coding gene Chr1:156876604-156898882 (-)
WSB/EiJ MGP_WSBEiJ_G0016018
protein coding gene Chr1:158202982-158223405 (-)



Homology
more
  • Human Ortholog
    MR1, major histocompatibility complex, class I-related
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MR1, major histocompatibility complex, class I-related
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HLALS
  • Links
    NCBI Gene ID: 3140
    neXtProt AC: NX_Q95460
    UniProt: Q95460

  • Chr Location
    1q25.3; chr1:181033379-181061938 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Null homozyogtes lack mucosal-associated invariant T cells that express the canonical mVa19-Ja33 rearrangement of the Tcra gene.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15064 NCBI Gene Model | MGI Sequence Detail 18942 C57BL/6J ±  kb
transcript NM_008209 RefSeq | MGI Sequence Detail 2555 C57BL/6  
polypeptide Q8HWB0 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001819 MHC class I-related gene protein
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
Molecular
Reagents
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  • All nucleic 28
    Genomic 5
    cDNA 23

    Microarray probesets 4
References
more
  • Summaries
    All 51
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:43255 Yamaguchi H, et al., A highly conserved major histocompatibility complex class I-related gene in mammals. Biochem Biophys Res Commun. 1997 Sep 29;238(3):697-702
  • Latest
    J:258417 D'Souza C, et al., Mucosal-Associated Invariant T Cells Augment Immunopathology and Gastritis in Chronic Helicobacter pylori Infection. J Immunol. 2018 Mar 1;200(5):1901-1916

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory