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Mr1 Gene Detail
Summary
  • Symbol
    Mr1
  • Name
    major histocompatibility complex, class I-related
  • Synonyms
    H2ls, MR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195463
    NCBI Gene: 15064
Location & Maps
more
  • Sequence Map
    Chr1:155127277-155146814 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      19538 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 66.45 cM, cytoband H1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MR1, major histocompatibility complex, class I-related
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MR1, major histocompatibility complex, class I-related
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HLALS
  • Links
    NCBI Gene ID: 3140
    neXtProt AC: NX_Q95460

  • Chr Location
    1q25.3; chr1:181033379-181061938 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    2
  • Targeted
    2
  • Genomic Mutations
    2 involving Mr1
  • Incidental Mutations
Null homozyogtes lack mucosal-associated invariant T cells that express the canonical mVa19-Ja33 rearrangement of the Tcra gene.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049823 VEGA Gene Model | MGI Sequence Detail 19538 C57BL/6J ±  kb
transcript OTTMUST00000126883 VEGA | MGI Sequence Detail 2512 Not Applicable  
polypeptide OTTMUSP00000068579 VEGA | MGI Sequence Detail 341 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    219 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001819 MHC class I-related gene protein
  • InterPro Domains
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
Molecular
Reagents
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  • All nucleic 28
    Genomic 5
    cDNA 23

    Microarray probesets 4
References
more
  • Summaries
    All 42
    Gene Ontology 3
    Phenotypes 17
  • Earliest
    J:43255 Yamaguchi H, et al., A highly conserved major histocompatibility complex class I-related gene in mammals. Biochem Biophys Res Commun. 1997 Sep 29;238(3):697-702
  • Latest
    J:227470 Cui Y, et al., Mucosal-associated invariant T cell-rich congenic mouse strain allows functional evaluation. J Clin Invest. 2015 Nov 2;125(11):4171-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory