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Gfra2
Gene Detail
Symbol

Name
ID
Gfra2
glial cell line derived neurotrophic factor family receptor alpha 2
MGI:1195462
Synonyms
GFR alpha 2, GFR alpha-2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.79 cM, cytoband D3-E1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:70890130-70979838 bp, + strand
From NCBI annotation of GRCm38

  89709 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1145  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: GDNF family receptor alpha
Gene Tree: Gfra2

Human
homologs
Human Homolog GFRA2, GDNF family receptor alpha 2
NCBI Gene ID 2675
neXtProt AC  NX_O00451
Human Synonyms  GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2
Human Chr (Location)  8p21.3; chr8:21692018-21814898 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants have dry eyes, poor postweaning growth associated with impaired parasympathetic cholinergic innervation of lacrimal and salivary glands and of small intestine, reduced skin thickness and accelerated hair follicle regression.
 
Interactions
Gfra2 interacts with 226 markers (Mir7-1, Mir16-1, Mir19a, ...)
Expression
Literature Summary: (37 records)
Data Summary: Results (102)    Tissues (31)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 67
Northern blot 12
RT-PCR 14
cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(38) Genomic(3) cDNA(30) Primer pair(2) Other(3)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000022103 (Evidence)
Entrez Gene14586 (Evidence)
UniGene32619
DFCITC1598844, TC1601205, TC1660594, TC1686803
DoTSDT.110752375, DT.110752381, DT.527662, DT.91341027
Consensus CDS ProjectCCDS27263.1
International Mouse Knockout Project StatusGfra2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14586 NCBI Gene Model | MGI Sequence Detail 89709 C57BL/6J ±  kb
transcript NM_008115 RefSeq | MGI Sequence Detail 3462 C57BL/6 
polypeptide O08842 UniProt | EBI | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(933 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016017 GDNF/GAS1
InterPro IPR003438 Glial cell line-derived neurotrophic factor receptor
InterPro IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2
InterPro IPR003504 Glial cell line-derived neurotrophic factor receptor alpha 2
Protein Ontology PR:000007949 GDNF family receptor alpha-2
Graphical View of Protein Domain Structure
References
(Earliest) J:44407 Luukko K, et al., Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis. Dev Dyn. 1997 Dec;210(4):463-71
(Latest) J:208103 Kupari J, et al., Lack of cholinergic innervation in gastric mucosa does not affect gastrin secretion or basal acid output in neurturin receptor GFRalpha2 deficient mice. J Physiol. 2013 Apr 15;591(Pt 8):2175-88
All references(80)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory