Gfra2
Gene Detail

Symbol Name ID

Gfra2 glial cell line derived neurotrophic factor family receptor alpha 2 MGI:1195462

Synonyms

GFR alpha 2, GFR alpha-2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

36.79 cM, cytoband D3-E1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:70890130-70979838 bp, + strand From NCBI annotation of GRCm38   89709 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1145  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: GDNF family receptor alpha
Gene Tree: Gfra2

Human homologs

Human Homolog		GFRA2, GDNF family receptor alpha 2
NCBI Gene ID		2675
neXtProt AC		NX_O00451
Human Synonyms		GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2
Human Chr (Location)		8p21.3; chr8:21549530-21646346 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous mutants have dry eyes, poor postweaning growth associated with impaired parasympathetic cholinergic innervation of lacrimal and salivary glands and of small intestine, reduced skin thickness and accelerated hair follicle regression.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	glial cell-derived neurotrophic factor receptor signaling pathway, negative regulation of protein autophosphorylation, ...
Component	anchored to membrane, membrane, ...
Function	glial cell-derived neurotrophic factor receptor activity, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (36 records)
Data Summary: Results (102)    Tissues (30)    Images (42)
Theiler Stages: 10, 18, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	67
Northern blot	12
RT-PCR	14

cDNA source data(27)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(38) Genomic(3) cDNA(30) Primer pair(2) Other(3)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000022103 (Evidence)
Entrez Gene	14586 (Evidence)
UniGene	32619
DFCI	TC1598844, TC1601205, TC1660594, TC1686803
DoTS	DT.110752375, DT.110752381, DT.527662, DT.91341027
Consensus CDS Project	CCDS27263.1
International Mouse Knockout Project Status	Gfra2

Sequences

Length	Strain/Species
genomic	14586	NCBI Gene Model | MGI Sequence Detail	89709	C57BL/6J
transcript	NM_008115	RefSeq | MGI Sequence Detail	3462	C57BL/6
polypeptide	O08842	UniProt | EBI | MGI Sequence Detail	463	Not Applicable

All sequences(30) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(645 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016017	GDNF/GAS1
InterPro	IPR003438	Glial cell line-derived neurotrophic factor receptor
InterPro	IPR017372	Glial cell line-derived neurotrophic factor receptor, alpha 1/2
InterPro	IPR003504	Glial cell line-derived neurotrophic factor receptor alpha 2
Protein Ontology	PR:000007949	GDNF family receptor alpha-2

Graphical View of Protein Domain Structure

References

(Earliest) J:44407 Luukko K, et al., Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis. Dev Dyn. 1997 Dec;210(4):463-71
(Latest) J:184447 Hu J, et al., c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections. J Neurosci. 2012 Apr 18;32(16):5362-73
All references(77)