Sept5
Gene Detail

Symbol Name ID

Sept5 septin 5 MGI:1195461

Synonyms

Cdcrel1, Pnutl1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

11.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr16:18621811-18629938 bp, - strand From NCBI annotation of GRCm38   8128 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:74446  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: septin
Gene Tree: Sept5

Human homologs

Human Homolog		SEPT5, septin 5
NCBI Gene ID		5413
neXtProt AC		NX_Q99719
Human Synonyms		CDCREL, CDCREL1, CDCREL-1, H5, HCDCREL-1, PNUTL1
Human Chr (Location)		22q11.21; chr22:19701987-19710845 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene show no gross phenotypic changes. Partial defects in synaptic transmission is reported for one allele, and platelet secretion and modest behavioral defects reported for a different allele.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	cell cycle, cell division, ...
Component	axon terminus, cell cortex, ...
Function	GDP binding, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (179)    Tissues (135)    Images (31)
Theiler Stages: 16, 17, 20, 22, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	19
RNA in situ	112
Western blot	16
RT-PCR	32

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(22) cDNA(12) Primer pair(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000072214 (Evidence)
Entrez Gene	18951 (Evidence)
Consensus CDS Project	CCDS57021.1
International Mouse Knockout Project Status	Sept5

Sequences

Length	Strain/Species
genomic	18951	NCBI Gene Model | MGI Sequence Detail	8128	C57BL/6J
transcript	NM_213614	RefSeq | MGI Sequence Detail	2155	C57BL/6
polypeptide	Q9Z2Q6	UniProt | EBI | MGI Sequence Detail	369	Not Applicable

All sequences(20) RefSeq(2) UniProt(4)

Protein-related information

Resource	ID	Description
InterPro	IPR000038	Cell division protein GTP binding
InterPro	IPR016491	Septin
Protein Ontology	PR:000014657	septin-5

Graphical View of Protein Domain Structure

References

(Earliest) J:43674 McKie JM, et al., A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11. Hum Genet. 1997 Nov;101(1):6-12
(Latest) J:191130 Maynard TM, et al., 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
All references(50)

Other accession IDs

MGI:1298391