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Sept5
Gene Detail
 Symbol
Name
ID
Sept5
septin 5
MGI:1195461
Synonyms Cdcrel1, Pnutl1
Feature Type protein coding gene
Genetic Map
Chromosome 16
11.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr16:18621811-18629938 bp, - strand
From NCBI annotation of GRCm38

  8128 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74446  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: septin
Gene Tree: Sept5

Human
homologs
Human Homolog SEPT5, septin 5
NCBI Gene ID 5413
neXtProt AC  NX_Q99719
Human Synonyms  CDCREL, CDCREL1, CDCREL-1, H5, HCDCREL-1, PNUTL1
Human Chr (Location)  22q11.21; chr22:19714464-19723322 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Sept5 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene show no gross phenotypic changes. Partial defects in synaptic transmission is reported for one allele, and platelet secretion and modest behavioral defects reported for a different allele.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Sept5 interacts with 100 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process cell cycle, cell division, ...
Component axon terminus, cell cortex, ...
Function GDP binding, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (179)    Tissues (138)    Images (31)
Theiler Stages: 16, 17, 20, 22, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 19
RNA in situ 112
Western blot 16
RT-PCR 32
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) Genomic(22) cDNA(12) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000072214 (Evidence)
Entrez Gene18951 (Evidence)
Consensus CDS ProjectCCDS57021.1
International Mouse Knockout Project StatusSept5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18951 NCBI Gene Model | MGI Sequence Detail 8128 C57BL/6J ±  kb
transcript NM_213614 RefSeq | MGI Sequence Detail 2155 C57BL/6 
polypeptide Q9Z2Q6 UniProt | EBI | MGI Sequence Detail 369 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(4)
Protein-related
information
ResourceIDDescription
InterPro IPR000038 Cell division protein GTP binding
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR016491 Septin
Protein Ontology PR:000014657 septin-5
Graphical View of Protein Domain Structure
References (Earliest) J:43674 McKie JM, et al., A human gene similar to Drosophila melanogaster peanut maps to the DiGeorge syndrome region of 22q11. Hum Genet. 1997 Nov;101(1):6-12
(Latest) J:191130 Maynard TM, et al., 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
All references(51)
Other
accession IDs
MGI:1298391

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory