Rnh1 MGI Mouse Gene Detail - MGI:1195456 - ribonuclease/angiogenin inhibitor 1

Symbol

Rnh1
Name

ribonuclease/angiogenin inhibitor 1
Synonyms

RNH

Feature Type

protein coding gene
IDs

MGI:1195456
NCBI Gene: 107702
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr7:140740239-140752764 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 86.44 cM
Mapping Data

1 experiment

SNPs within 2kb

37 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1195456	protein coding gene	Chr7:140740239-140752770 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0033213	protein coding gene	Chr7:146334828-146347351 (-)
A/J	MGP_AJ_G0033195	protein coding gene	Chr7:142151493-142164016 (-)
AKR/J	MGP_AKRJ_G0033127	protein coding gene	Chr7:146068263-146080771 (-)
BALB/cJ	MGP_BALBcJ_G0033196	protein coding gene	Chr7:141892055-141904574 (-)
C3H/HeJ	MGP_C3HHeJ_G0032910	protein coding gene	Chr7:145822279-145835718 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033707	protein coding gene	Chr7:151684820-151698677 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030680	protein coding gene	Chr7:143359875-143372478 (-)
CAST/EiJ	MGP_CASTEiJ_G0032240	protein coding gene	Chr7:138127993-138140593 (-)
CBA/J	MGP_CBAJ_G0032882	protein coding gene	Chr7:156795204-156807683 (-)
DBA/2J	MGP_DBA2J_G0033034	protein coding gene	Chr7:140098585-140111133 (-)
FVB/NJ	MGP_FVBNJ_G0032987	protein coding gene	Chr7:140007243-140020672 (-)
LP/J	MGP_LPJ_G0033129	protein coding gene	Chr7:147824614-147837137 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033020	protein coding gene	Chr7:157477834-157490429 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033727	protein coding gene	Chr7:145047236-145059759 (-)
PWK/PhJ	MGP_PWKPhJ_G0031944	protein coding gene	Chr7:133376220-133389219 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031791	protein coding gene	Chr7:131864358-131879917 (-)
WSB/EiJ	MGP_WSBEiJ_G0032351	protein coding gene	Chr7:145994448-146006889 (-)

Human Ortholog

RNH1, ribonuclease/angiogenin inhibitor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNH1, ribonuclease/angiogenin inhibitor 1
Synonyms

IIAE12, RAI, RNH
Links

HGNC:10074

NCBI Gene ID: 6050

neXtProt AC: NX_P13489

UniProt: P13489
Chr Location

11p15.5; chr11:494512-507300 (-) GRCh38

MGI Vertebrate Homology

Rnh1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: RNH1
Gene Tree

Rnh1

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Endonuclease-mediated

3
Gene trapped

20
Radiation induced

1
Targeted

4
Genomic Mutations

1 involving Rnh1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit complete embryonic lethality and anemia associated with defects in embryonic erythropoiesis, erythroid differentiation, and GATA1 translation. Heterozygotes exhibit decreased adult erythropoiesis in spleen.

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All GO Annotations

15
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

729
Tissues

7
cDNA Data

260
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA RNH1

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All Sequences

60
RefSeq

6
UniProt

5
CCDS

CCDS22002.1, CCDS85455.1

Ensembl

ENSMUSG00000038650 (Evidence)
NCBI Gene

107702

			Length	Strain/Species	Flank
genomic	107702	NCBI Gene Model \| MGI Sequence Detail	12526	C57BL/6J	± kb
transcript	NM_145135	RefSeq \| MGI Sequence Detail	1807	C57BL/6
polypeptide	Q91VI7	UniProt \| EBI \| MGI Sequence Detail	456	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000014143 ribonuclease inhibitor

(term hierarchy)
PDB

3TSR
InterPro Domains

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR041302 Ribonuclease inhibitor, leucine rich repeat cap

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All nucleic 261

cDNA 260

Primer pair 1

Microarray probesets 3

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MGI:2142254, MGI:2142343

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 4

Phenotypes 12
Earliest

J:41448 Semsei I, et al., Expression of mRNAs of pancreatic and L type RNase inhibitors as a function of age in different tissues of SAMP8 and BDF1 mice. Mech Ageing Dev. 1997 Sep;97(3):249-61
Latest

J:331827 Bombaci G, et al., LRR-protein RNH1 dampens the inflammasome activation and is associated with COVID-19 severity. Life Sci Alliance. 2022 Jun;5(6):e202101226

TSS for Rnh1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr75594	Chr7:140752722-140752775 (-)	15 bp
Tssr75593	Chr7:140752701-140752716 (-)	55 bp
Tssr75592	Chr7:140751073-140751094 (-)	1,680 bp
Tssr75591	Chr7:140748584-140748724 (-)	4,110 bp
Tssr75590	Chr7:140748570-140748579 (-)	4,189 bp
Tssr75589	Chr7:140747783-140747822 (-)	4,961 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23