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Rdh1
Gene Detail
Symbol

Name
ID
Rdh1
retinol dehydrogenase 1 (all trans)
MGI:1195275
Feature Type
protein coding gene
Genetic Map
Chromosome 10
75.21 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:127759721-127768297 bp, + strand
From VEGA annotation of GRCm38

  8577 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:129514  Vertebrate Homology Class
1 human; 5 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 8 western clawed frog; 1 zebrafish

HCOP human homology predictions: RDH16
Protein SuperFamily: retinol dehydrogenase
Gene Tree: Rdh1

Human
homologs
RDH16, retinol dehydrogenase 16 (all-trans)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8608
neXtProt AC: NX_O75452

Human Synonyms: RODH-4, SDR9C8

Human Chr (Location): 12q13.3; chr12:56951431-56959374 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased body weight, adipose tissue, and retinol levels.
 
Interactions
Rdh1 interacts with 238 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Process oxidation-reduction process, retinoid metabolic process, ...
Function retinol dehydrogenase activity, steroid dehydrogenase activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (5)    Tissues (5)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 5
cDNA source data(4)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(4) Primer pair(2)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000027662 (Evidence)
Ensembl Gene Model ENSMUSG00000089789 (Evidence)
Entrez Gene 107605 (Evidence)
UniGene 484271
DFCI TC1599785
DoTS DT.97394999
NIA Mouse Gene Index U335256
Consensus CDS Project CCDS24250.1
International Mouse Phenotyping Consortium Status Rdh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027662 VEGA Gene Model | MGI Sequence Detail 8577 C57BL/6J ±  kb
transcript OTTMUST00000068444 VEGA | MGI Sequence Detail 3930 Not Applicable 
polypeptide OTTMUSP00000034612 VEGA | MGI Sequence Detail 317 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(69 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR020904 Short-chain dehydrogenase/reductase, conserved site
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
References
(Earliest) J:44704 Driessen CA, et al., Cloning and structural analysis of the murine GCN5L1 gene. Gene. 1997 Dec 5;203(1):27-31
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory