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Aqp8
Gene Detail
 Symbol
Name
ID
Aqp8
aquaporin 8
MGI:1195271
Feature Type protein coding gene
Genetic Map
Chromosome 7
67.42 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:123462294-123468003 bp, + strand
From NCBI annotation of GRCm38

  5710 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68166  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: aquaporin
Gene Tree: Aqp8

Human
homologs
Human Homolog AQP8, aquaporin 8
NCBI Gene ID 343
neXtProt AC  NX_O94778
Human Synonyms  AQP-8
Human Chr (Location)  16p12; chr16:25216964-25228932 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a disruption in this gene results in enlarged testes and a reduction in water permeability in plasma membrane of testes.
 
Interactions
Aqp8 interacts with 80 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process canalicular bile acid transport, transmembrane transport, ...
Component apical part of cell, integral component of membrane, ...
Function transporter activity, water channel activity
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (109)    Tissues (87)    Images (8)
Theiler Stages: 1, 2, 3, 4, 5, 12, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 49
Northern blot 6
Western blot 2
RT-PCR 46
cDNA source data(74)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) Genomic(1) cDNA(74) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030762 (Evidence)
Entrez Gene11833 (Evidence)
UniGene273175
DFCITC1584921, TC1622520, TC1716029
DoTSDT.533356, DT.97376186
NIA Mouse Gene IndexU008743
Consensus CDS ProjectCCDS72038.1
International Mouse Knockout Project StatusAqp8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 11833 NCBI Gene Model | MGI Sequence Detail 5710 C57BL/6J ±  kb
transcript NM_007474 RefSeq | MGI Sequence Detail 1486 C57BL/6 
polypeptide P56404 UniProt | EBI | MGI Sequence Detail 261 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(87 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023277 Aquaporin 8
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
InterPro IPR022357 Major intrinsic protein, conserved site
Protein Ontology PR:000004188 aquaporin-8
Graphical View of Protein Domain Structure
References (Earliest) J:44349 Ma T, et al., Cloning of a novel water and urea-permeable aquaporin from mouse expressed strongly in colon, placenta, liver, and heart. Biochem Biophys Res Commun. 1997 Nov 17;240(2):324-8
(Latest) J:187177 Bochkis IM, et al., Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. PLoS Genet. 2012 Jun;8(6):e1002770
All references(47)
Other
accession IDs
MGI:2141886

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory