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Slc22a12
Gene Detail
Symbol

Name
ID
Slc22a12
solute carrier family 22 (organic anion/cation transporter), member 12
MGI:1195269
Synonyms
Rst, URAT1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.05 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:6535845-6543019 bp, - strand
From VEGA annotation of GRCm38

  7175 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: SLC22A12
Gene Tree: Slc22a12

Human
homologs
SLC22A12, solute carrier family 22 (organic anion/urate transporter), member 12
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 116085
neXtProt AC: NX_Q96S37

Human Synonyms: OAT4L, RST, URAT1

Human Chr (Location): 11q13.1; chr11:64590810-64602353 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC22A12

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for a null allele exhibit increased urinary urate levels and altered urine and plasma metabolite composition.
 
Interactions
Slc22a12 interacts with 37 markers (Mir22, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process anion transmembrane transport, ion transport, ...
Component apical plasma membrane, brush border membrane, ...
Function inorganic anion exchanger activity, PDZ domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (194)    Tissues (111)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
In situ reporter (knock in) 56
RT-PCR 40
cDNA source data(66)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(69) cDNA(66) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000018619 (Evidence)
Ensembl Gene Model ENSMUSG00000061742 (Evidence)
Entrez Gene 20521 (Evidence)
UniGene 391146
DFCI TC1652603, TC1581508
DoTS DT.50316822, DT.101359017
NIA Mouse Gene Index U112960
Consensus CDS Project CCDS29505.1
International Mouse Phenotyping Consortium Status Slc22a12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018619 VEGA Gene Model | MGI Sequence Detail 7175 C57BL/6J ±  kb
transcript OTTMUST00000044832 VEGA | MGI Sequence Detail 2213 Not Applicable 
polypeptide OTTMUSP00000020168 VEGA | MGI Sequence Detail 553 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR020846 Major facilitator superfamily domain
Protein Ontology PR:000014983 solute carrier family 22 member 12
References
(Earliest) J:44355 Mori K, et al., Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett. 1997 Nov 17;417(3):371-4
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)
Other
accession IDs
MGI:2147622

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory