Slc22a12
Gene Detail

Symbol Name ID

Slc22a12 solute carrier family 22 (organic anion/cation transporter), member 12 MGI:1195269

Synonyms

Rst, URAT1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

5.05 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr19:6535845-6543019 bp, - strand From VEGA annotation of GRCm38   7175 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Slc22a12 ± 2 cM)

Gene Tree: Slc22a12

Human ortholog

SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 NCBI Gene ID 116085
Human Synonyms: OAT4L, RST, URAT1
Human Chr11:64358282-64369820 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SLC22A12 (1)

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a null allele exhibit increased urinary urate levels and altered urine and plasma metabolite composition.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	ion transport, response to drug, ...
Component	apical plasma membrane, brush border membrane, ...
Function	PDZ domain binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (147)    Tissues (67)    Images (32)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	51
In situ reporter (knock in)	56
RT-PCR	40

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(11) Primer pair(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000018619 (Evidence)
Ensembl Gene Model	ENSMUSG00000061742 (Evidence)
Entrez Gene	20521 (Evidence)
DFCI	TC1581508, TC1652603
DoTS	DT.101359017, DT.50316822
NIA Mouse Gene Index	U112960
Consensus CDS Project	CCDS29505.1
International Mouse Knockout Project Status	Slc22a12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018619	VEGA Gene Model | MGI Sequence Detail	7175	C57BL/6J
transcript	OTTMUST00000044832	VEGA | MGI Sequence Detail	2213	Not Applicable
polypeptide	OTTMUSP00000020168	VEGA | MGI Sequence Detail	553	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(64 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005828	General substrate transporter
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
Protein Ontology	PR:000014983	solute carrier family 22 member 12

References

(Earliest) J:44355 Mori K, et al., Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett. 1997 Nov 17;417(3):371-4
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)

Other accession IDs

MGI:2147622