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Slc22a12 Gene Detail
Summary
  • Symbol
    Slc22a12
  • Name
    solute carrier family 22 (organic anion/cation transporter), member 12
  • Synonyms
    Rst, URAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195269
    NCBI Gene: 20521
  • Gene Overview
    MyGene.info: SLC22A12
Location & Maps
more
  • Genetic Map
    Chromosome 19, 5.05 cM, cytoband A
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    SLC22A12, solute carrier family 22 member 12
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC22A12, solute carrier family 22 member 12
    Orthology source: HGNC, HomoloGene
  • Synonyms
    OAT4L, RST, URAT1
  • Links
    NCBI Gene ID: 116085
    neXtProt AC: NX_Q96S37

  • Chr Location
    11q13.1; chr11:64590810-64602353 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SLC22A12 associations

Human Disease Mouse Models
       Hypouricemia, Renal, 1; RHUC1   OMIM: 220150
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
Mice homozygous for a null allele exhibit increased urinary urate levels and altered urine and plasma metabolite composition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018619 VEGA Gene Model | MGI Sequence Detail 7175 C57BL/6J ±  kb
transcript OTTMUST00000044832 VEGA | MGI Sequence Detail 2213 Not Applicable  
polypeptide OTTMUSP00000020168 VEGA | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    73 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • InterPro Domains
    IPR005828 Major facilitator, sugar transporter-like
    IPR020846 Major facilitator superfamily domain
Molecular
Reagents
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  • All nucleic 69
    cDNA 66
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
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MGI:2147622
References
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  • Summaries
    All 34
    Developmental Gene Expression 5
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:44355 Mori K, et al., Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett. 1997 Nov 17;417(3):371-4
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory