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Slc22a12
Gene Detail
Symbol

Name
ID
Slc22a12
solute carrier family 22 (organic anion/cation transporter), member 12
MGI:1195269
Synonyms
Rst, URAT1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
5.05 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:6535845-6543019 bp, - strand
From VEGA annotation of GRCm38

  7175 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56442  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Slc22a12

Human
homologs
Human Homolog SLC22A12, solute carrier family 22 (organic anion/urate transporter), member 12
NCBI Gene ID 116085
neXtProt AC  NX_Q96S37
Human Synonyms  OAT4L, RST, URAT1
Human Chr (Location)  11q13.1; chr11:64590641-64602353 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC22A12
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
 
Mice homozygous for a null allele exhibit increased urinary urate levels and altered urine and plasma metabolite composition.
 
Interactions
Slc22a12 interacts with 37 markers (Mir22, Mir28b, Mir28c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process ion transport, organic acid transport, ...
Component apical plasma membrane, brush border membrane, ...
Function PDZ domain binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (194)    Tissues (111)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
In situ reporter (knock in) 56
RT-PCR 40
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(69) cDNA(66) Primer pair(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000018619 (Evidence)
Ensembl Gene ModelENSMUSG00000061742 (Evidence)
Entrez Gene20521 (Evidence)
UniGene391146
DFCITC1652603, TC1581508
DoTSDT.50316822, DT.101359017
NIA Mouse Gene IndexU112960
Consensus CDS ProjectCCDS29505.1
International Mouse Knockout Project StatusSlc22a12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018619 VEGA Gene Model | MGI Sequence Detail 7175 C57BL/6J ±  kb
transcript OTTMUST00000044832 VEGA | MGI Sequence Detail 2213 Not Applicable 
polypeptide OTTMUSP00000020168 VEGA | MGI Sequence Detail 553 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(73 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005828 General substrate transporter
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
Protein Ontology PR:000014983 solute carrier family 22 member 12
References
(Earliest) J:44355 Mori K, et al., Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett. 1997 Nov 17;417(3):371-4
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(38)
Other
accession IDs
MGI:2147622

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory