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Slc22a12 Gene Detail
Summary
  • Symbol
    Slc22a12
  • Name
    solute carrier family 22 (organic anion/cation transporter), member 12
  • Synonyms
    Rst, URAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195269
    NCBI Gene: 20521
  • Gene Overview
    MyGene.info: SLC22A12
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 19, 5.05 cM, cytoband A
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC22A12, solute carrier family 22 member 12
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SLC22A12, solute carrier family 22 member 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    OAT4L, RST, URAT1
  • Links
    NCBI Gene ID: 116085
    neXtProt AC: NX_Q96S37
    UniProt: Q96S37

  • Chr Location
    11q13.1; chr11:64590810-64603250 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased urinary urate levels and altered urine and plasma metabolite composition.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000018619 VEGA Gene Model | MGI Sequence Detail 7175 C57BL/6J ±  kb
    transcript OTTMUST00000044832 VEGA | MGI Sequence Detail 2213 Not Applicable  
    polypeptide OTTMUSP00000020168 VEGA | MGI Sequence Detail 553 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      73 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR005828 Major facilitator, sugar transporter-like
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
    Molecular
    Reagents
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    • All nucleic 69
      cDNA 66
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
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    MGI:2147622
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:44355 Mori K, et al., Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett. 1997 Nov 17;417(3):371-4
    • Latest
      J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory