About   Help   FAQ
Slc22a12 Gene Detail
Summary
  • Symbol
    Slc22a12
  • Name
    solute carrier family 22 (organic anion/cation transporter), member 12
  • Synonyms
    Rst, URAT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195269
    NCBI Gene: 20521
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6585875-6593062 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 5.05 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195269
protein coding gene Chr19:6585875-6593100 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024765
protein coding gene Chr19:3604925-3612099 (-)
A/J MGP_AJ_G0024731
protein coding gene Chr19:3403010-3410184 (-)
AKR/J MGP_AKRJ_G0024704
protein coding gene Chr19:3503333-3510507 (-)
BALB/cJ MGP_BALBcJ_G0024731
protein coding gene Chr19:3401971-3409139 (-)
C3H/HeJ MGP_C3HHeJ_G0024499
protein coding gene Chr19:3524538-3531712 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025177
protein coding gene Chr19:3663133-3670307 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022611
protein coding gene Chr19:3329359-3336692 (-)
CAST/EiJ MGP_CASTEiJ_G0023971
protein coding gene Chr19:3546776-3553940 (-)
CBA/J MGP_CBAJ_G0024471
protein coding gene Chr19:3847599-3854810 (-)
DBA/2J MGP_DBA2J_G0024598
protein coding gene Chr19:3389457-3396964 (-)
FVB/NJ MGP_FVBNJ_G0024564
protein coding gene Chr19:3408672-3415841 (-)
LP/J MGP_LPJ_G0024684
protein coding gene Chr19:3564091-3571213 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024593
protein coding gene Chr19:3648536-3655710 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025225
protein coding gene Chr19:3529203-3536377 (-)
PWK/PhJ MGP_PWKPhJ_G0023717
protein coding gene Chr19:3427646-3435196 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023522
protein coding gene Chr19:3485044-3492207 (-)
WSB/EiJ MGP_WSBEiJ_G0024033
protein coding gene Chr19:3545529-3552693 (-)



Homology
more
  • Human Ortholog
    SLC22A12, solute carrier family 22 member 12
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC22A12, solute carrier family 22 member 12
  • Synonyms
    hURAT1, OAT4L, RST, UAT, URAT1
  • Links
    NCBI Gene ID: 116085
    neXtProt AC: NX_Q96S37
    UniProt: Q96S37

  • Chr Location
    11q13.1; chr11:64590641-64602353 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased urinary urate levels and altered urine and plasma metabolite composition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061742 Ensembl Gene Model | MGI Sequence Detail 7188 C57BL/6J ±  kb
    transcript ENSMUST00000113451 Ensembl | MGI Sequence Detail 2226 Not Applicable  
    polypeptide ENSMUSP00000109078 Ensembl | MGI Sequence Detail 553 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 67
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147622
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:44355 Mori K, et al., Kidney-specific expression of a novel mouse organic cation transporter-like protein. FEBS Lett. 1997 Nov 17;417(3):371-4
    • Latest
      J:338261 Toyoda Y, et al., Vitamin C transporter SVCT1 serves a physiological role as a urate importer: functional analyses and in vivo investigations. Pflugers Arch. 2023 Apr;475(4):489-504

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory