Sigmar1
Gene Detail

Symbol Name ID

Sigmar1 sigma non-opioid intracellular receptor 1 MGI:1195268

Synonyms

mSigmaR1, Oprs1

Feature Type

protein coding gene

Genetic Map

Chromosome 4

22.05 cM, cytoband A5-B2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:41738493-41756157 bp, - strand From VEGA annotation of GRCm38   17665 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; guinea pig    (Mammalian Orthology)
Comparative Map (Mouse/Human Sigmar1 ± 2 cM)

Protein SuperFamily: Sigma 1-type opioid receptor, eukaryotic type
Gene Tree: Sigmar1

Human ortholog

SIGMAR1 sigma non-opioid intracellular receptor 1 NCBI Gene ID 10280
Human Synonyms: ALS16, OPRS1, SRBP, SR-BP1
Human Chr9:34634719-34637768 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SIGMAR1 (1)

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

Mice homozygous for a gene trapped allele exhibit abnormal motor coordination and increased depressive-like behavior. Mice homozygous for a knock-out allele exhibit reduced sponataneous activity.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	ergosterol biosynthetic process, lipid transport, ...
Component	cell junction, cell projection, ...
Function	C-8 sterol isomerase activity, opioid receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (65)    Tissues (41)    Images (2)
Theiler Stages: 11, 15, 19, 20, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	32
Northern blot	30
Western blot	3

cDNA source data(93)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(95) Genomic(2) cDNA(93)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000006675 (Evidence)
Ensembl Gene Model	ENSMUSG00000036078 (Evidence)
Entrez Gene	18391 (Evidence)
UniGene	425181
DFCI	TC1578447, TC1599535, TC1601974, TC1666524
DoTS	DT.101137835, DT.87074086, DT.94368606
NIA Mouse Gene Index	U024979
Consensus CDS Project	CCDS18070.1
International Mouse Knockout Project Status	Sigmar1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006675	VEGA Gene Model | MGI Sequence Detail	17665	C57BL/6J
transcript	OTTMUST00000015282	VEGA | MGI Sequence Detail	1640	Not Applicable
polypeptide	OTTMUSP00000007061	VEGA | MGI Sequence Detail	223	Not Applicable

All sequences(58) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(6 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006716	ERG2/sigma1 receptor-like
Protein Ontology	PR:000011650	sigma 1-type opioid receptor

References

(Earliest) J:44925 Seth P, et al., Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun. 1997 Dec 18;241(2):535-40
(Latest) J:192545 Ha Y, et al., Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1. Mol Vis. 2012;18:2860-70
All references(54)

Other accession IDs

MGI:2140414