About   Help   FAQ
Sigmar1 Gene Detail
Summary
  • Symbol
    Sigmar1
  • Name
    sigma non-opioid intracellular receptor 1
  • Synonyms
    mSigmaR1, Oprs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195268
    NCBI Gene: 18391
  • Gene Overview
    MyGene.info: SIGMAR1
Location & Maps
more
  • Sequence Map
    Chr4:41738493-41756157 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17665 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 22.05 cM, cytoband A5-B2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SIGMAR1, sigma non-opioid intracellular receptor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIGMAR1, sigma non-opioid intracellular receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALS16, DSMA2, hSigmaR1, OPRS1, SIG-1R, sigma1R, SRBP, SR-BP, SR-BP1
  • Links
    NCBI Gene ID: 10280
    neXtProt AC: NX_Q99720

  • Chr Location
    9p13.3; chr9:34634722-34637826 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human SIGMAR1 associations

Human Disease Mouse Models
       Amyotrophic Lateral Sclerosis 16, Juvenile; ALS16   OMIM: 614373
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 2; DSMA2   OMIM: 605726
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically and radiation induced
    1
  • Gene trapped
    2
  • Targeted
    2
  • Genomic Mutations
    1 involving Sigmar1
  • Incidental Mutations
Mice homozygous for a gene trapped allele exhibit abnormal motor coordination and increased depressive-like behavior. Mice homozygous for a knock-out allele exhibit reduced sponataneous activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006675 VEGA Gene Model | MGI Sequence Detail 17665 C57BL/6J ±  kb
transcript OTTMUST00000015282 VEGA | MGI Sequence Detail 1640 Not Applicable  
polypeptide OTTMUSP00000007061 VEGA | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    270 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000011650 sigma non-opioid intracellular receptor 1
  • InterPro Domains
    IPR006716 ERG2/sigma1 receptor-like
Molecular
Reagents
less
  • All nucleic 93
    Genomic 2
    cDNA 91

    Microarray probesets 6
Other
Accession IDs
less
MGI:2140414
References
more
  • Summaries
    All 62
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 26
  • Earliest
    J:44925 Seth P, et al., Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun. 1997 Dec 18;241(2):535-40
  • Latest
    J:228062 Tsai SY, et al., Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):E6562-70

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory