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Sigmar1
Gene Detail
 Symbol
Name
ID
Sigmar1
sigma non-opioid intracellular receptor 1
MGI:1195268
Synonyms mSigmaR1, Oprs1
Feature Type protein coding gene
Genetic Map
Chromosome 4
22.05 cM, cytoband A5-B2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:41738493-41756157 bp, - strand
From VEGA annotation of GRCm38

  17665 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39965  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Sigma 1-type opioid receptor, eukaryotic type
Gene Tree: Sigmar1

Human
homologs
Human Homolog SIGMAR1, sigma non-opioid intracellular receptor 1
NCBI Gene ID 10280
neXtProt AC  NX_Q99720
Human Synonyms  ALS16, hSigmaR1, OPRS1, SIG-1R, sigma1R, SRBP, SR-BP, SR-BP1
Human Chr (Location)  9p13.3; chr9:34634722-34637826 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SIGMAR1
Alleles
and
phenotypes
All alleles(4) : Targeted(2) Gene trapped(2)
 
Mice homozygous for a gene trapped allele exhibit abnormal motor coordination and increased depressive-like behavior. Mice homozygous for a knock-out allele exhibit reduced sponataneous activity.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process lipid transport, nervous system development, ...
Component cell junction, cell projection, ...
Function opioid receptor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (65)    Tissues (41)    Images (2)
Theiler Stages: 11, 15, 19, 20, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 32
Northern blot 30
Western blot 3
cDNA source data(91)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(93) Genomic(2) cDNA(91)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000006675 (Evidence)
Ensembl Gene ModelENSMUSG00000036078 (Evidence)
Entrez Gene18391 (Evidence)
UniGene425181
DFCITC1578447, TC1599535, TC1601974, TC1666524, TC1671744, TC1684883
DoTSDT.101137835, DT.87074086, DT.94368606, DT.97342399
NIA Mouse Gene IndexU024979
Consensus CDS ProjectCCDS18070.1
International Mouse Knockout Project StatusSigmar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006675 VEGA Gene Model | MGI Sequence Detail 17665 C57BL/6J ±  kb
transcript OTTMUST00000015282 VEGA | MGI Sequence Detail 1640 Not Applicable 
polypeptide OTTMUSP00000007061 VEGA | MGI Sequence Detail 223 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(16) UniProt(7)
Polymorphisms SNPs within 2kb(270 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006716 ERG2/sigma1 receptor-like
Protein Ontology PR:000011650 sigma 1-type opioid receptor
References (Earliest) J:44925 Seth P, et al., Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun. 1997 Dec 18;241(2):535-40
(Latest) J:201365 Mavlyutov TA, et al., Lack of sigma-1 receptor exacerbates ALS progression in mice. Neuroscience. 2013 Jun 14;240:129-34
All references(58)
Other
accession IDs
MGI:2140414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory