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Sigmar1 Gene Detail
Summary
  • Symbol
    Sigmar1
  • Name
    sigma non-opioid intracellular receptor 1
  • Synonyms
    mSigmaR1, Oprs1, Sig1R
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195268
    NCBI Gene: 18391
  • Gene Overview
    MyGene.info: SIGMAR1
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:41738493-41755257 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 22.05 cM, cytoband A5-B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    253 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195268
protein coding gene Chr4:41738493-41756157 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028171
protein coding gene Chr4:39704427-39723041 (-)
A/J MGP_AJ_G0028129
protein coding gene Chr4:38194916-38212610 (-)
AKR/J MGP_AKRJ_G0028092
protein coding gene Chr4:39183468-39204722 (-)
BALB/cJ MGP_BALBcJ_G0028142
protein coding gene Chr4:38537712-38555283 (-)
C3H/HeJ MGP_C3HHeJ_G0027880
protein coding gene Chr4:39776812-39794405 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028583
protein coding gene Chr4:41201129-41218818 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027325
protein coding gene Chr4:39421515-39439227 (-)
CBA/J MGP_CBAJ_G0027842
protein coding gene Chr4:42570712-42590898 (-)
DBA/2J MGP_DBA2J_G0027986
protein coding gene Chr4:38122483-38140580 (-)
FVB/NJ MGP_FVBNJ_G0027953
protein coding gene Chr4:37442066-37460927 (-)
LP/J MGP_LPJ_G0028094
protein coding gene Chr4:39795188-39813794 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027985
protein coding gene Chr4:45884250-45902982 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028641
protein coding gene Chr4:39296519-39315405 (-)
PWK/PhJ MGP_PWKPhJ_G0027044
protein coding gene Chr4:38163884-38181659 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026871
protein coding gene Chr4:39026901-39046849 (-)
WSB/EiJ MGP_WSBEiJ_G0027401
protein coding gene Chr4:39280660-39299071 (-)



Homology
more
  • Human Ortholog
    SIGMAR1, sigma non-opioid intracellular receptor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIGMAR1, sigma non-opioid intracellular receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALS16, DSMA2, hSigmaR1, OPRS1, SIG-1R, sigma1R, SRBP, SR-BP, SR-BP1
  • Links
    NCBI Gene ID: 10280
    neXtProt AC: NX_Q99720
    UniProt: Q99720

  • Chr Location
    9p13.3; chr9:34634722-34637826 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human SIGMAR1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit abnormal motor coordination and increased depressive-like behavior. Mice homozygous for a knock-out allele exhibit reduced sponataneous activity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18391 NCBI Gene Model | MGI Sequence Detail 16765 C57BL/6J ±  kb
transcript NM_011014 RefSeq | MGI Sequence Detail 1640 C57BL/6  
polypeptide O55242 UniProt | EBI | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 94
    Genomic 2
    cDNA 92

    Microarray probesets 6
Other
Accession IDs
less
MGI:2140414
References
more
  • Summaries
    All 86
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 41
  • Earliest
    J:44925 Seth P, et al., Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun. 1997 Dec 18;241(2):535-40
  • Latest
    J:262621 Castany S, et al., Critical role of sigma-1 receptors in central neuropathic pain-related behaviours after mild spinal cord injury in mice. Sci Rep. 2018 Mar 1;8(1):3873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory