Lims1
Gene Detail

Symbol Name ID

Lims1 LIM and senescent cell antigen-like domains 1 MGI:1195263

Synonyms

2310016J22Rik, 4921524A02Rik, C430041B13Rik, Lims1l, PINCH1

Feature Type

protein coding gene

Genetic Map

Chromosome 10

29.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr10:58323466-58424691 bp, + strand From VEGA annotation of GRCm38   101226 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: PINCH protein
Gene Tree: Lims1

Human homologs

Human Homolog		LIMS1, LIM and senescent cell antigen-like domains 1
NCBI Gene ID		3987
neXtProt AC		NX_P48059
Human Synonyms		PINCH, PINCH1, PINCH-1
Human Chr (Location)		2q12.3; chr2:109150811-109303702 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(63) : Targeted(7) Gene trapped(56)
 

Homozygous null mice die shortly after implantation and have a disorganized egg cylinder by E5.5, which is degenerated by E6.5. E5.5 null embryos exhibit decreased cell proliferation and excessive cell death.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell-cell adhesion, cell-cell junction organization, ...
Component	cell junction, focal adhesion, ...
Function	metal ion binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (376)    Tissues (133)    Images (48)
Theiler Stages: 2, 3, 4, 5, 7, 9, 11, 17, 19, 20, 21, 23, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	354
Western blot	2
RT-PCR	18

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) cDNA(27) Primer pair(3)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000024823 (Evidence)
Ensembl Gene Model	ENSMUSG00000019920 (Evidence)
Entrez Gene	110829 (Evidence)
DFCI	TC1576181, TC1587266, TC1591811, TC1599645, TC1601054, TC1699293
DoTS	DT.101387792, DT.110605481, DT.87072540, DT.91329704, DT.94222883
NIA Mouse Gene Index	U043076
Consensus CDS Project	CCDS23860.1, CCDS56703.1
International Mouse Knockout Project Status	Lims1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024823	VEGA Gene Model | MGI Sequence Detail	101226	C57BL/6J
transcript	OTTMUST00000061127	VEGA | MGI Sequence Detail	1565	Not Applicable
polypeptide	OTTMUSP00000029920	VEGA | MGI Sequence Detail	396	Not Applicable

All sequences(69) RefSeq(6) UniProt(6)

Polymorphisms

PCR(1) : SNPs(213 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017351	PINCH
InterPro	IPR001781	Zinc finger, LIM-type
Protein Ontology	PR:000009818	LIM and senescent cell antigen-like-containing domain protein 1

References

(Earliest) J:44723 Rearden A, A new LIM protein containing an autoepitope homologous to senescent cell antigen. Biochem Biophys Res Commun. 1994 Jun 30;201(3):1124-31
(Latest) J:172853 Kohr MJ, et al., Characterization of potential S-nitrosylation sites in the myocardium. Am J Physiol Heart Circ Physiol. 2011 Apr;300(4):H1327-35
All references(59)

Other accession IDs

MGI:1914678, MGI:1919149, MGI:2143635, MGI:2143741, MGI:2143862, MGI:2445157