About   Help   FAQ
Lims1 Gene Detail
Summary
  • Symbol
    Lims1
  • Name
    LIM and senescent cell antigen-like domains 1
  • Synonyms
    2310016J22Rik, 4921524A02Rik, C430041B13Rik, Lims1l, PINCH1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195263
    NCBI Gene: 110829
  • Gene Overview
    MyGene.info: LIMS1
Location & Maps
more
  • Sequence Map
    Chr10:58323466-58424691 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      101226 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    LIMS1, LIM zinc finger domain containing 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LIMS1, LIM zinc finger domain containing 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PINCH, PINCH1, PINCH-1
  • Links
    NCBI Gene ID: 3987
    neXtProt AC: NX_P48059

  • Chr Location
    2q12.3; chr2:108534355-108687246 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 5 alleles in 3 genetic backgrounds
    22 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    65
  • Chemically induced (other)
    1
  • Gene trapped
    56
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Lims1
  • Incidental Mutations
Homozygous null mice die shortly after implantation and have a disorganized egg cylinder by E5.5, which is degenerated by E6.5. E5.5 null embryos exhibit decreased cell proliferation and excessive cell death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024823 VEGA Gene Model | MGI Sequence Detail 101226 C57BL/6J ±  kb
transcript OTTMUST00000061127 VEGA | MGI Sequence Detail 1565 Not Applicable  
polypeptide OTTMUSP00000029920 VEGA | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    377 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    7 Sequences
  • InterPro Domains
    IPR017351 LIM and senescent cell antigen-like-containing domain protein 1
    IPR001781 Zinc finger, LIM-type
Molecular
Reagents
less
  • All nucleic 30
    cDNA 27
    Primer pair 3

    Microarray probesets 8
Other
Accession IDs
less
MGI:1914678, MGI:1919149, MGI:2143635, MGI:2143741, MGI:2143862, MGI:2445157
References
more
  • Summaries
    All 59
    Developmental Gene Expression 13
    Gene Ontology 11
    Phenotypes 21
  • Earliest
    J:44723 Rearden A, A new LIM protein containing an autoepitope homologous to senescent cell antigen. Biochem Biophys Res Commun. 1994 Jun 30;201(3):1124-31
  • Latest
    J:223845 Karakose E, et al., The focal adhesion protein PINCH-1 associates with EPLIN at integrin adhesion sites. J Cell Sci. 2015 Mar 1;128(5):1023-33

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/19/2016
MGI 6.03
The Jackson Laboratory