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Lims1
Gene Detail
Symbol

Name
ID
Lims1
LIM and senescent cell antigen-like domains 1
MGI:1195263
Synonyms
2310016J22Rik, 4921524A02Rik, C430041B13Rik, Lims1l, PINCH1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
29.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:58323466-58424691 bp, + strand
From VEGA annotation of GRCm38

  101226 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68428  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: PINCH protein
Gene Tree: Lims1

Human
homologs
Human Homolog LIMS1, LIM and senescent cell antigen-like domains 1
NCBI Gene ID 3987
neXtProt AC  NX_P48059
Human Synonyms  PINCH, PINCH1, PINCH-1
Human Chr (Location)  2q12.3; chr2:108534355-108687246 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(63) : Gene trapped(56) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die shortly after implantation and have a disorganized egg cylinder by E5.5, which is degenerated by E6.5. E5.5 null embryos exhibit decreased cell proliferation and excessive cell death.
 
Interactions
Lims1 interacts with 350 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell-cell junction organization, cell-matrix adhesion, ...
Component cell-cell junction, cell junction, ...
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (369)    Tissues (137)    Images (48)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 354
Western blot 2
RT-PCR 11
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(30) cDNA(27) Primer pair(3)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000024823 (Evidence)
Ensembl Gene ModelENSMUSG00000019920 (Evidence)
Entrez Gene110829 (Evidence)
DFCITC1601054, TC1699293, TC1591811, TC1587266, TC1576181, TC1599645
DoTSDT.94222883, DT.91329704, DT.101387792, DT.110605481, DT.87072540
NIA Mouse Gene IndexU043076
Consensus CDS ProjectCCDS23860.1, CCDS56703.1
International Mouse Knockout Project StatusLims1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024823 VEGA Gene Model | MGI Sequence Detail 101226 C57BL/6J ±  kb
transcript OTTMUST00000061127 VEGA | MGI Sequence Detail 1565 Not Applicable 
polypeptide OTTMUSP00000029920 VEGA | MGI Sequence Detail 396 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(20) UniProt(11)
Polymorphisms
PCR(1) : SNPs within 2kb(378 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017351 PINCH
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009818 LIM and senescent cell antigen-like-containing domain protein 1
References
(Earliest) J:44723 Rearden A, A new LIM protein containing an autoepitope homologous to senescent cell antigen. Biochem Biophys Res Commun. 1994 Jun 30;201(3):1124-31
(Latest) J:208112 Porcheri C, et al., Dissecting integrin-dependent regulation of neural stem cell proliferation in the adult brain. J Neurosci. 2014 Apr 9;34(15):5222-32
All references(62)
Other
accession IDs
MGI:1914678, MGI:1919149, MGI:2143635, MGI:2143741, MGI:2143862, MGI:2445157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory