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Man2b2 Gene Detail
Summary
  • Symbol
    Man2b2
  • Name
    mannosidase 2, alpha B2
  • Synonyms
    135 kDa alpha-D-mannosidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195262
    NCBI Gene: 17160
  • Gene Overview
    MyGene.info: MAN2B2
Location & Maps
more
  • Sequence Map
    Chr5:36806921-36830653 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23733 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 19.26 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAN2B2, mannosidase alpha class 2B member 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    MAN2B2, mannosidase alpha class 2B member 2
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 23324
    neXtProt AC: NX_Q9Y2E5

  • Chr Location
    4p16.1; chr4:6575174-6622403 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Radiation induced
    5
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    9 involving Man2b2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024727 VEGA Gene Model | MGI Sequence Detail 23733 C57BL/6J ±  kb
transcript OTTMUST00000060872 VEGA | MGI Sequence Detail 3330 Not Applicable  
polypeptide OTTMUSP00000029754 VEGA | MGI Sequence Detail 1018 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    137 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010108 epididymis-specific alpha-mannosidase
  • EC
  • InterPro Domains
    IPR011013 Galactose mutarotase-like domain
    IPR027291 Glycoside hydrolase 38/57, N-terminal domain
    IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
    IPR028995 Glycoside hydrolase families 57/38, central domain
    IPR015341 Glycoside hydrolase family 38, central domain
    IPR000602 Glycoside hydrolase family 38, N-terminal domain
    IPR013780 Glycosyl hydrolase, all-beta
    IPR011682 Glycosyl hydrolase family 38, C-terminal
Molecular
Reagents
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  • All nucleic 45
    cDNA 44
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 25
  • Earliest
    J:44927 Hiramoto S, et al., Stage-specific expression of a mouse homologue of the porcine 135kDa alpha-D-mannosidase (MAN2B2) in type A spermatogonia. Biochem Biophys Res Commun. 1997 Dec 18;241(2):439-45
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory