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Man2b2 Gene Detail
Summary
  • Symbol
    Man2b2
  • Name
    mannosidase 2, alpha B2
  • Synonyms
    135 kDa alpha-D-mannosidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195262
    NCBI Gene: 17160
  • Gene Overview
    MyGene.info: MAN2B2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:36806921-36830653 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23733 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 19.26 cM, cytoband B2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAN2B2, mannosidase alpha class 2B member 2
  • Vertebrate Orthologs
    12
  • Human Ortholog
    MAN2B2, mannosidase alpha class 2B member 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 23324
    neXtProt AC: NX_Q9Y2E5
    UniProt: Q9Y2E5

  • Chr Location
    4p16.1; chr4:6575174-6622403 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024727 VEGA Gene Model | MGI Sequence Detail 23733 C57BL/6J ±  kb
    transcript OTTMUST00000060872 VEGA | MGI Sequence Detail 3330 Not Applicable  
    polypeptide OTTMUSP00000029754 VEGA | MGI Sequence Detail 1018 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      137 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000010108 epididymis-specific alpha-mannosidase
    • EC
    • InterPro Domains
      IPR011013 Galactose mutarotase-like domain superfamily
      IPR027291 Glycoside hydrolase 38, N-terminal domain superfamily
      IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
      IPR028995 Glycoside hydrolase families 57/38, central domain superfamily
      IPR015341 Glycoside hydrolase family 38, central domain
      IPR037094 Glycoside hydrolase family 38, central domain superfamily
      IPR000602 Glycoside hydrolase family 38, N-terminal domain
      IPR013780 Glycosyl hydrolase, all-beta
      IPR011682 Glycosyl hydrolase family 38, C-terminal
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 44
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 26
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory