About   Help   FAQ
Eef2k
Gene Detail
Symbol

Name
ID
Eef2k
eukaryotic elongation factor-2 kinase
MGI:1195261
Synonyms
eEF-2K
Feature Type
protein coding gene
Genetic Map
Chromosome 7
64.95 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:120842831-120907219 bp, + strand
From VEGA annotation of GRCm38

  64389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EEF2K
Protein SuperFamily: elongation factor 2 kinase
Gene Tree: Eef2k

Human
homologs
EEF2K, eukaryotic elongation factor 2 kinase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 29904
neXtProt AC: NX_O00418

Human Synonyms: eEF-2K, HSU93850

Human Chr (Location): 16p12.2; chr16:22206271-22288745 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit impaired regulation of ovarian follicular degeneration and apoptosis, prolonged estrus, and increased ovarian follicle numbers in aged females.
 
Interactions
Eef2k interacts with 374 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process phosphorylation, protein autophosphorylation, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
Northern blot 8
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase eef2k ; ZFIN eef2k    NEW 
Molecular
reagents
All nucleic(20) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000026126 (Evidence)
Ensembl Gene Model ENSMUSG00000035064 (Evidence)
Entrez Gene 13631 (Evidence)
DFCI TC1665126, TC1619718, TC1576127, TC1711929
DoTS DT.101140918, DT.486762, DT.101200716, DT.521759, DT.94341999
NIA Mouse Gene Index U185453, U008712, U008711
EC 2.7.11.20
Consensus CDS Project CCDS21796.1
International Mouse Phenotyping Consortium Status Eef2k
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026126 VEGA Gene Model | MGI Sequence Detail 64389 C57BL/6J ±  kb
transcript OTTMUST00000064514 VEGA | MGI Sequence Detail 6349 Not Applicable 
polypeptide OTTMUSP00000032054 VEGA | MGI Sequence Detail 724 Not Applicable 

For the selected sequences
All sequences(107) RefSeq(17) UniProt(9)
Polymorphisms
SNPs within 2kb(428 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017400 Elongation factor 2 kinase
InterPro IPR004166 MHCK/EF2 kinase
InterPro IPR011009 Protein kinase-like domain
InterPro IPR006597 Sel1-like
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000006910 elongation factor 2 kinase
References
(Earliest) J:16608 Gschwendt M, et al., Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994 Jan 24;338(1):85-8
(Latest) J:208406 Chu HP, et al., Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev Cell. 2014 Mar 10;28(5):561-72
All references(43)
Other
accession IDs
MGI:2142363

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory