Eef2k MGI Mouse Gene Detail - MGI:1195261 - eukaryotic elongation factor-2 kinase

Symbol

Eef2k
Name

eukaryotic elongation factor-2 kinase
Synonyms

eEF-2K

Feature Type

protein coding gene
IDs

MGI:1195261
NCBI Gene: 13631
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:120442080-120506441 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 64.95 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

1774 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1195261	protein coding gene	Chr7:120442054-120506673 (+)
129S1/SvImJ	ENSMUSG00200021944	protein coding gene	Chr7:106978527-107027643 (+)
A/J	ENSMUSG00195034036	protein coding gene	Chr7:111502426-111551518 (+)
AKR/J	ENSMUSG00220018954	protein coding gene	Chr7:104939203-104988317 (+)
BALB/cJ	ENSMUSG00180031337	protein coding gene	Chr7:108170151-108219263 (+)
C3H/HeJ	ENSMUSG00175024946	protein coding gene	Chr7:108883636-108932751 (+)
C57BL/6NJ	ENSMUSG00215014620	protein coding gene	Chr7:108133683-108182797 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030400	protein coding gene	Chr7:122974888-123041374 (+)
CAST/EiJ	ENSTCUG00005038847	protein coding gene	Chr7:111439106-111488793 (+)
CBA/J	ENSMUSG00210024092	protein coding gene	Chr7:108611415-108660525 (+)
DBA/2J	ENSMUSG00185047828	protein coding gene	Chr7:112957241-113006354 (+)
FVB/NJ	ENSMUSG00205022063	protein coding gene	Chr7:108617610-108666725 (+)
JF1/MsJ	ENSUMUG00000021955	protein coding gene	Chr7:118034480-118084845 (+)
LP/J	ENSMUSG00230034568	protein coding gene	Chr7:119065164-119114282 (+)
NOD/ShiLtJ	ENSMUSG00190018814	protein coding gene	Chr7:108809941-108859059 (+)
NZO/HlLtJ	ENSMUSG00225037705	protein coding gene	Chr7:117315489-117364602 (+)
PWK/PhJ	ENSLUMG00010011939	protein coding gene	Chr7:107150959-107200077 (+)
SPRET/EiJ	ENSMSPG00010007583	protein coding gene	Chr7:108354076-108408358 (+)
WSB/EiJ	ENSIUOG00005011978	protein coding gene	Chr7:109496438-109545571 (+)

Human Ortholog

EEF2K, eukaryotic elongation factor 2 kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EEF2K, eukaryotic elongation factor 2 kinase
Synonyms

CaMKIII, eEF-2K, HSU93850
Links

HGNC:24615

NCBI Gene ID: 29904

UniProt: O00418
Chr Location

16p12.2; chr16:22206272-22288738 (+) GRCh38

MGI Vertebrate Homology

Eef2k stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EEF2K
Protein SuperFamily

Elongation_factor_2_kinase
Gene Tree

Eef2k

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Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

6
Gene trapped

9
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired regulation of ovarian follicular degeneration and apoptosis, prolonged estrus, and increased ovarian follicle numbers in aged females. Knockout also affects behavior in response to novel objects.

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All GO Annotations

46
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

627
Tissues

24
cDNA Data

19
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eef2k

ZFIN eef2k

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All Sequences

104
RefSeq

23
UniProt

10
CCDS

CCDS21796.1

Ensembl

ENSMUSG00000035064 (Evidence)
NCBI Gene

13631

			Length	Strain/Species	Flank
genomic	13631	NCBI Gene Model \| MGI Sequence Detail	64362	C57BL/6J	± kb
transcript	NM_001412329	RefSeq \| MGI Sequence Detail	6391	C57BL/6
polypeptide	O08796	UniProt \| EBI \| MGI Sequence Detail	724	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006910 elongation factor 2 kinase

(term hierarchy)
EC

2.7.11.20
InterPro Domains

IPR051852 Alpha-type Protein Kinase

IPR004166 Alpha-type protein kinase, alpha-kinase domain

IPR017400 Eukaryotic elongation factor 2 kinase

IPR047588 Eukaryotic elongation factor 2 kinase, alpha-kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR006597 Sel1-like repeat

IPR011990 Tetratricopeptide-like helical domain superfamily
GlyGen

O08796 1 site, 1 O-linked glycan (1 site)

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All nucleic 21

cDNA 19

Primer pair 1

Other 1

Microarray probesets 8

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MGI:2142363

Summaries

All 82

Developmental Gene Expression 2

Gene Ontology 10

Phenotypes 33
Earliest

J:16608 Gschwendt M, et al., Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994 Jan 24;338(1):85-8
Latest

J:363830 Smith PR, et al., eEF2K regulates pain through translational control of BDNF. Mol Cell. 2024 Dec 14;

TSS for Eef2k:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68795	Chr7:120441966-120441981 (+)	-106 bp
Tssr68796	Chr7:120442047-120442059 (+)	-27 bp
Tssr68797	Chr7:120442061-120442133 (+)	17 bp
Tssr68798	Chr7:120442139-120442148 (+)	64 bp
Tssr68799	Chr7:120442774-120442795 (+)	705 bp
Tssr68800	Chr7:120450406-120450417 (+)	8,332 bp
Tssr68801	Chr7:120475427-120475450 (+)	33,359 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24