About   Help   FAQ
Eef2k Gene Detail
Summary
  • Symbol
    Eef2k
  • Name
    eukaryotic elongation factor-2 kinase
  • Synonyms
    eEF-2K
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195261
    NCBI Gene: 13631
  • Gene Overview
    MyGene.info: EEF2K
Location & Maps
more
  • Sequence Map
    Chr7:120842831-120907450 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      64620 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 64.95 cM, cytoband F3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EEF2K, eukaryotic elongation factor 2 kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EEF2K, eukaryotic elongation factor 2 kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    eEF-2K, HSU93850
  • Links
    NCBI Gene ID: 29904
    neXtProt AC: NX_O00418
    UniProt: O00418

  • Chr Location
    16p12.2; chr16:22206264-22288745 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired regulation of ovarian follicular degeneration and apoptosis, prolonged estrus, and increased ovarian follicle numbers in aged females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    30
  • Tissues
    24
  • cDNA Data
    18
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026126 VEGA Gene Model | MGI Sequence Detail 64620 C57BL/6J ±  kb
transcript OTTMUST00000064514 VEGA | MGI Sequence Detail 6580 Not Applicable  
polypeptide OTTMUSP00000032054 VEGA | MGI Sequence Detail 724 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    424 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 18
    Primer pair 1
    Other 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:2142363
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:16608 Gschwendt M, et al., Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994 Jan 24;338(1):85-8
  • Latest
    J:241098 Heise C, et al., eEF2K/eEF2 Pathway Controls the Excitation/Inhibition Balance and Susceptibility to Epileptic Seizures. Cereb Cortex. 2017 Mar 01;27(3):2226-2248
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/19/2017
MGI 6.10 		The Jackson Laboratory