Eef2k MGI Mouse Gene Detail - MGI:1195261 - eukaryotic elongation factor-2 kinase

Eef2k Gene Detail

Symbol

Eef2k
Name

eukaryotic elongation factor-2 kinase
Synonyms

eEF-2K

Feature Type

protein coding gene
IDs

MGI:1195261
NCBI Gene: 13631
Gene Overview

MyGene.info: EEF2K

Sequence Map

Chr7:120842831-120907450 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

64620 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 64.95 cM, cytoband F3
Mapping Data

3 experiments

Human Ortholog

EEF2K, eukaryotic elongation factor 2 kinase

Vertebrate Orthologs

10

Human Ortholog

EEF2K, eukaryotic elongation factor 2 kinase
Orthology source: HomoloGene, HGNC
Synonyms

eEF-2K, HSU93850
Links

HGNC:24615

NCBI Gene ID: 29904

neXtProt AC: NX_O00418
Chr Location

16p12.2; chr16:22206271-22288745 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 7299
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: EEF2K
Protein SuperFamily

elongation factor 2 kinase
Gene Tree

Eef2k

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Phenotype Summary

16 phenotypes from 2 alleles in 3 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Gene trapped

11
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a knock-out allele exhibit impaired regulation of ovarian follicular degeneration and apoptosis, prolonged estrus, and increased ovarian follicle numbers in aged females.

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All GO Annotations

25
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

30
Tissues

24
cDNA Data

18
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase eef2k

ZFIN eef2k

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Eef2k interacts with 374 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

97
RefSeq

17
UniProt

10
CCDS

CCDS21796.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000026126	VEGA Gene Model \| MGI Sequence Detail	64620	C57BL/6J	± kb
transcript	OTTMUST00000064514	VEGA \| MGI Sequence Detail	6580	Not Applicable
polypeptide	OTTMUSP00000032054	VEGA \| MGI Sequence Detail	724	Not Applicable

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SNPs within 2kb

424 from dbSNP Build 142

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UniProt

10 Sequences
Protein Ontology

PR:000006910 elongation factor 2 kinase
EC

2.7.11.20
InterPro Domains

IPR017400 Eukaryotic elongation factor 2 kinase

IPR004166 MHCK/EF2 kinase

IPR011009 Protein kinase-like domain

IPR006597 Sel1-like repeat

IPR011990 Tetratricopeptide-like helical domain

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All nucleic 20

cDNA 18

Primer pair 1

Other 1

Microarray probesets 8

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MGI:2142363

Summaries

All 43

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 10
Earliest

J:16608 Gschwendt M, et al., Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994 Jan 24;338(1):85-8
Latest

J:224568 Wang X, et al., Regulated stability of eukaryotic elongation factor 2 kinase requires intrinsic but not ongoing activity. Biochem J. 2015 Apr 15;467(2):321-31

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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