Eef2k
Gene Detail

Symbol

Name
ID

Eef2k
eukaryotic elongation factor-2 kinase
MGI:1195261

Synonyms

eEF-2K

Feature Type

protein coding gene

Genetic Map

Chromosome 7
64.95 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:120842831-120907219 bp, + strand From VEGA annotation of GRCm38   64389 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: elongation factor 2 kinase
Gene Tree: Eef2k

Human
homologs

Human Homolog		EEF2K, eukaryotic elongation factor 2 kinase
NCBI Gene ID		29904
neXtProt AC		NX_O00418
Human Synonyms		eEF-2K, HSU93850
Human Chr (Location)		16p12.2; chr16:22206271-22288745 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(13) : Gene trapped(11) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit impaired regulation of ovarian follicular degeneration and apoptosis, prolonged estrus, and increased ovarian follicle numbers in aged females.

 

Interactions

Eef2k interacts with 375 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	phosphorylation, protein autophosphorylation, ...
Function	ATP binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (30)    Tissues (24)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	22
Northern blot	8

cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(20) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(8)

Other database
links

VEGA Gene Model	OTTMUSG00000026126 (Evidence)
Ensembl Gene Model	ENSMUSG00000035064 (Evidence)
Entrez Gene	13631 (Evidence)
DFCI	TC1619718, TC1711929, TC1576127, TC1665126
DoTS	DT.521759, DT.94341999, DT.486762, DT.101140918, DT.101200716
NIA Mouse Gene Index	U008712, U008711, U185453
EC	2.7.11.20
Consensus CDS Project	CCDS21796.1
International Mouse Knockout Project Status	Eef2k

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026126	VEGA Gene Model | MGI Sequence Detail	64389	C57BL/6J
transcript	OTTMUST00000064514	VEGA | MGI Sequence Detail	6349	Not Applicable
polypeptide	OTTMUSP00000032054	VEGA | MGI Sequence Detail	724	Not Applicable

All sequences(107) RefSeq(17) UniProt(9)

Polymorphisms

SNPs within 2kb(428 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017400	Elongation factor 2 kinase
InterPro	IPR004166	MHCK/EF2 kinase
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR006597	Sel1-like
InterPro	IPR011990	Tetratricopeptide-like helical
Protein Ontology	PR:000006910	elongation factor 2 kinase

References

(Earliest) J:16608 Gschwendt M, et al., Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994 Jan 24;338(1):85-8
(Latest) J:208406 Chu HP, et al., Germline quality control: eEF2K stands guard to eliminate defective oocytes. Dev Cell. 2014 Mar 10;28(5):561-72
All references(45)

Other
accession IDs

MGI:2142363