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Eef2k
Gene Detail
Symbol

Name
ID
Eef2k
eukaryotic elongation factor-2 kinase
MGI:1195261
Synonyms
eEF-2K
Feature Type
protein coding gene
Genetic Map
Chromosome 7
64.95 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:120842831-120907219 bp, + strand
From VEGA annotation of GRCm38

  64389 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: elongation factor 2 kinase
Gene Tree: Eef2k

Human
homologs
Human Homolog EEF2K, eukaryotic elongation factor-2 kinase
NCBI Gene ID 29904
neXtProt AC  NX_O00418
Human Synonyms  eEF-2K, HSU93850
Human Chr (Location)  16p12.2; chr16:22206271-22288745 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit a resistance to resveratrol inhibition of injury-induced choroidal neovascularization.
 
Interactions
Eef2k interacts with 375 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process phosphorylation, protein autophosphorylation, ...
Function ATP binding, calcium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (30)    Tissues (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 22
Northern blot 8
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000026126 (Evidence)
Ensembl Gene ModelENSMUSG00000035064 (Evidence)
Entrez Gene13631 (Evidence)
DFCITC1576127, TC1619718, TC1665126, TC1711929
DoTSDT.101140918, DT.101200716, DT.486762, DT.521759, DT.94341999
EC2.7.11.20
Consensus CDS ProjectCCDS21796.1
International Mouse Knockout Project StatusEef2k
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026126 VEGA Gene Model | MGI Sequence Detail 64389 C57BL/6J ±  kb
transcript OTTMUST00000064514 VEGA | MGI Sequence Detail 6349 Not Applicable 
polypeptide OTTMUSP00000032054 VEGA | MGI Sequence Detail 724 Not Applicable 

For the selected sequences
All sequences(104) RefSeq(17) UniProt(9)
Polymorphisms
SNPs within 2kb(428 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017400 Elongation factor 2 kinase
InterPro IPR004166 MHCK/EF2 kinase
InterPro IPR011009 Protein kinase-like domain
InterPro IPR006597 Sel1-like
InterPro IPR011990 Tetratricopeptide-like helical
Protein Ontology PR:000006910 elongation factor 2 kinase
References
(Earliest) J:16608 Gschwendt M, et al., Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994 Jan 24;338(1):85-8
(Latest) J:196965 Nosyreva E, et al., Acute suppression of spontaneous neurotransmission drives synaptic potentiation. J Neurosci. 2013 Apr 17;33(16):6990-7002
All references(43)
Other
accession IDs
MGI:2142363

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory