Eef2k
Gene Detail

Symbol Name ID

Eef2k eukaryotic elongation factor-2 kinase MGI:1195261

Synonyms

eEF-2K

Feature Type

protein coding gene

Genetic Map

Chromosome 7

64.95 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr7:120842831-120907219 bp, + strand From VEGA annotation of GRCm38   64389 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7299  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: elongation factor 2 kinase
Gene Tree: Eef2k

Human homologs

Human Homolog		EEF2K, eukaryotic elongation factor-2 kinase
NCBI Gene ID		29904
neXtProt AC		NX_O00418
Human Synonyms		eEF-2K, HSU93850
Human Chr (Location)		16p12.2; chr16:22206271-22288745 (+)  GRCh38

Alleles and phenotypes

All alleles(13) : Gene trapped(11) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele exhibit a resistance to resveratrol inhibition of injury-induced choroidal neovascularization.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	phosphorylation, protein autophosphorylation, ...
Function	ATP binding, calcium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (30)    Tissues (22)   
Theiler Stages: 21, 23, 26, 28

Assay Type	Results
RNA in situ	22
Northern blot	8

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(18) Primer pair(1) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000026126 (Evidence)
Ensembl Gene Model	ENSMUSG00000035064 (Evidence)
Entrez Gene	13631 (Evidence)
DFCI	TC1576127, TC1619718, TC1665126, TC1711929
DoTS	DT.101140918, DT.101200716, DT.486762, DT.521759, DT.94341999
EC	2.7.11.20
Consensus CDS Project	CCDS21796.1
International Mouse Knockout Project Status	Eef2k

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026126	VEGA Gene Model | MGI Sequence Detail	64389	C57BL/6J
transcript	OTTMUST00000064514	VEGA | MGI Sequence Detail	6349	Not Applicable
polypeptide	OTTMUSP00000032054	VEGA | MGI Sequence Detail	724	Not Applicable

All sequences(104) RefSeq(17) UniProt(9)

Polymorphisms

SNPs within 2kb(428 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017400	Elongation factor 2 kinase
InterPro	IPR004166	MHCK/EF2 kinase
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR006597	Sel1-like
InterPro	IPR011990	Tetratricopeptide-like helical
Protein Ontology	PR:000006910	elongation factor 2 kinase

References

(Earliest) J:16608 Gschwendt M, et al., Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994 Jan 24;338(1):85-8
(Latest) J:196965 Nosyreva E, et al., Acute suppression of spontaneous neurotransmission drives synaptic potentiation. J Neurosci. 2013 Apr 17;33(16):6990-7002
All references(43)

Other accession IDs

MGI:2142363