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Eef2k Gene Detail
Summary
  • Symbol
    Eef2k
  • Name
    eukaryotic elongation factor-2 kinase
  • Synonyms
    eEF-2K
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195261
    NCBI Gene: 13631
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:120441961-120506442 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 64.95 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    421 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195261
 protein coding gene Chr7:120441961-120506673 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032934
 protein coding gene Chr7:124846437-124918416 (+)
A/J MGP_AJ_G0032917
 protein coding gene Chr7:121591650-121656808 (+)
AKR/J MGP_AKRJ_G0032849
 protein coding gene Chr7:124714629-124782684 (+)
BALB/cJ MGP_BALBcJ_G0032922
 protein coding gene Chr7:121310354-121377699 (+)
C3H/HeJ MGP_C3HHeJ_G0032632
 protein coding gene Chr7:124624205-124691273 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033428
 protein coding gene Chr7:129789422-129862382 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030400
 protein coding gene Chr7:122974888-123041374 (+)
CAST/EiJ MGP_CASTEiJ_G0031960
 protein coding gene Chr7:116385495-116453778 (+)
CBA/J MGP_CBAJ_G0032605
 protein coding gene Chr7:134114543-134185233 (+)
DBA/2J MGP_DBA2J_G0032757
 protein coding gene Chr7:119629120-119693865 (+)
FVB/NJ MGP_FVBNJ_G0032710
 protein coding gene Chr7:119489363-119556297 (+)
LP/J MGP_LPJ_G0032851
 protein coding gene Chr7:126293859-126362706 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032742
 protein coding gene Chr7:135587106-135658275 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033448
 protein coding gene Chr7:123702049-123769111 (+)
PWK/PhJ MGP_PWKPhJ_G0031668
 protein coding gene Chr7:112557823-112624040 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031514
 protein coding gene Chr7:110458761-110532161 (+)
WSB/EiJ MGP_WSBEiJ_G0032073
 protein coding gene Chr7:124628245-124700134 (+)



Homology
more
  • Human Ortholog
    EEF2K, eukaryotic elongation factor 2 kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EEF2K, eukaryotic elongation factor 2 kinase
  • Synonyms
    CaMKIII, eEF-2K, HSU93850
  • Links
    NCBI Gene ID: 29904
    neXtProt AC: NX_O00418
    UniProt: O00418

  • Chr Location
    16p12.2; chr16:22206264-22288745 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired regulation of ovarian follicular degeneration and apoptosis, prolonged estrus, and increased ovarian follicle numbers in aged females. Knockout also affects behavior in response to novel objects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    702
  • Tissues
    24
  • cDNA Data
    19
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13631 NCBI Gene Model | MGI Sequence Detail 64482 C57BL/6J ±  kb
    transcript NM_007908 RefSeq | MGI Sequence Detail 6366 C57BL/6  
    polypeptide O08796 UniProt | EBI | MGI Sequence Detail 724 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 1
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2142363
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:16608 Gschwendt M, et al., Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994 Jan 24;338(1):85-8
    • Latest
      J:316407 Knight JR, et al., Rpl24(Bst) mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K. Elife. 2021 Dec 13;10:e69729
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    06/14/2022
    MGI 6.19     		The Jackson Laboratory