Eef2k MGI Mouse Gene Detail - MGI:1195261 - eukaryotic elongation factor-2 kinase

Symbol

Eef2k
Name

eukaryotic elongation factor-2 kinase
Synonyms

eEF-2K

Feature Type

protein coding gene
IDs

MGI:1195261
NCBI Gene: 13631
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr7:120442080-120506441 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 64.95 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

3466 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1195261	protein coding gene	Chr7:120442054-120506673 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032934	protein coding gene	Chr7:124846437-124918416 (+)
A/J	MGP_AJ_G0032917	protein coding gene	Chr7:121591650-121656808 (+)
AKR/J	MGP_AKRJ_G0032849	protein coding gene	Chr7:124714629-124782684 (+)
BALB/cJ	MGP_BALBcJ_G0032922	protein coding gene	Chr7:121310354-121377699 (+)
C3H/HeJ	MGP_C3HHeJ_G0032632	protein coding gene	Chr7:124624205-124691273 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033428	protein coding gene	Chr7:129789422-129862382 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030400	protein coding gene	Chr7:122974888-123041374 (+)
CAST/EiJ	MGP_CASTEiJ_G0031960	protein coding gene	Chr7:116385495-116453778 (+)
CBA/J	MGP_CBAJ_G0032605	protein coding gene	Chr7:134114543-134185233 (+)
DBA/2J	MGP_DBA2J_G0032757	protein coding gene	Chr7:119629120-119693865 (+)
FVB/NJ	MGP_FVBNJ_G0032710	protein coding gene	Chr7:119489363-119556297 (+)
LP/J	MGP_LPJ_G0032851	protein coding gene	Chr7:126293859-126362706 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032742	protein coding gene	Chr7:135587106-135658275 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033448	protein coding gene	Chr7:123702049-123769111 (+)
PWK/PhJ	MGP_PWKPhJ_G0031668	protein coding gene	Chr7:112557823-112624040 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031514	protein coding gene	Chr7:110458761-110532161 (+)
WSB/EiJ	MGP_WSBEiJ_G0032073	protein coding gene	Chr7:124628245-124700134 (+)

Human Ortholog

EEF2K, eukaryotic elongation factor 2 kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EEF2K, eukaryotic elongation factor 2 kinase
Synonyms

CaMKIII, eEF-2K, HSU93850
Links

HGNC:24615

NCBI Gene ID: 29904

UniProt: O00418
Chr Location

16p12.2; chr16:22206278-22288738 (+) GRCh38

MGI Vertebrate Homology

Eef2k stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EEF2K
Protein SuperFamily

Elongation_factor_2_kinase
Gene Tree

Eef2k

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Phenotype Summary

18 phenotypes from 2 alleles in 3 genetic backgrounds
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Endonuclease-mediated

5
Gene trapped

9
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit impaired regulation of ovarian follicular degeneration and apoptosis, prolonged estrus, and increased ovarian follicle numbers in aged females. Knockout also affects behavior in response to novel objects.

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All GO Annotations

52
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

24
cDNA Data

19
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase eef2k

ZFIN eef2k

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All Sequences

103
RefSeq

23
UniProt

10
CCDS

CCDS21796.1

Ensembl

ENSMUSG00000035064 (Evidence)
NCBI Gene

13631

			Length	Strain/Species	Flank
genomic	13631	NCBI Gene Model \| MGI Sequence Detail	64362	C57BL/6J	± kb
transcript	NM_001412329	RefSeq \| MGI Sequence Detail	6391	C57BL/6
polypeptide	O08796	UniProt \| EBI \| MGI Sequence Detail	724	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006910 elongation factor 2 kinase

(term hierarchy)
EC

2.7.11.20
InterPro Domains

IPR051852 Alpha-type Protein Kinase

IPR004166 Alpha-type protein kinase, alpha-kinase domain

IPR017400 Eukaryotic elongation factor 2 kinase

IPR047588 Eukaryotic elongation factor 2 kinase, alpha-kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR006597 Sel1-like repeat

IPR011990 Tetratricopeptide-like helical domain superfamily
GlyGen

O08796 1 site, 1 O-linked glycan (1 site)

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All nucleic 21

cDNA 19

Primer pair 1

Other 1

Microarray probesets 8

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MGI:2142363

Summaries

All 73

Developmental Gene Expression 2

Gene Ontology 11

Phenotypes 31
Earliest

J:16608 Gschwendt M, et al., Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994 Jan 24;338(1):85-8
Latest

J:363830 Smith PR, et al., eEF2K regulates pain through translational control of BDNF. Mol Cell. 2024 Dec 14;

TSS for Eef2k:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68795	Chr7:120441966-120441981 (+)	-106 bp
Tssr68796	Chr7:120442047-120442059 (+)	-27 bp
Tssr68797	Chr7:120442061-120442133 (+)	17 bp
Tssr68798	Chr7:120442139-120442148 (+)	64 bp
Tssr68799	Chr7:120442774-120442795 (+)	705 bp
Tssr68800	Chr7:120450406-120450417 (+)	8,332 bp
Tssr68801	Chr7:120475427-120475450 (+)	33,359 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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