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Eef2k Gene Detail
Summary
  • Symbol
    Eef2k
  • Name
    eukaryotic elongation factor-2 kinase
  • Synonyms
    eEF-2K
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195261
    NCBI Gene: 13631
  • Gene Overview
    MyGene.info: EEF2K
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:120842831-120907450 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      64620 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 64.95 cM, cytoband F3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EEF2K, eukaryotic elongation factor 2 kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EEF2K, eukaryotic elongation factor 2 kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CaMKIII, eEF-2K, HSU93850
  • Links
    NCBI Gene ID: 29904
    neXtProt AC: NX_O00418
    UniProt: O00418

  • Chr Location
    16p12.2; chr16:22206264-22288745 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired regulation of ovarian follicular degeneration and apoptosis, prolonged estrus, and increased ovarian follicle numbers in aged females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    30
  • Tissues
    24
  • cDNA Data
    19
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026126 VEGA Gene Model | MGI Sequence Detail 64620 C57BL/6J ±  kb
    transcript OTTMUST00000064514 VEGA | MGI Sequence Detail 6580 Not Applicable  
    polypeptide OTTMUSP00000032054 VEGA | MGI Sequence Detail 724 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      424 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 19
      Primer pair 1
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2142363
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:16608 Gschwendt M, et al., Elongation factor-2 kinase: effective inhibition by the novel protein kinase inhibitor rottlerin and relative insensitivity towards staurosporine. FEBS Lett. 1994 Jan 24;338(1):85-8
    • Latest
      J:244763 Crawford DC, et al., Selective molecular impairment of spontaneous neurotransmission modulates synaptic efficacy. Nat Commun. 2017 Feb 10;8:14436
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory