Fxyd2 MGI Mouse Gene Detail - MGI:1195260 - FXYD domain-containing ion transport regulator 2

Symbol

Fxyd2
Name

FXYD domain-containing ion transport regulator 2
Synonyms

Atp1g1

Feature Type

protein coding gene
IDs

MGI:1195260
NCBI Gene: 11936
Alliance

gene page
Transcription Start Sites

18 TSS

Sequence Map

Chr9:45311007-45321576 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 24.84 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

842 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1195260	protein coding gene	Chr9:45310967-45321576 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034738	protein coding gene	Chr9:43962219-43969445 (+)
A/J	MGP_AJ_G0034719	protein coding gene	Chr9:42737030-42744199 (+)
AKR/J	MGP_AKRJ_G0034646	protein coding gene	Chr9:43611845-43619132 (+)
BALB/cJ	MGP_BALBcJ_G0034710	protein coding gene	Chr9:42464394-42471538 (+)
C3H/HeJ	MGP_C3HHeJ_G0034421	protein coding gene	Chr9:44069152-44076292 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0035231	protein coding gene	Chr9:45250375-45257522 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032145	protein coding gene	Chr9:42281967-42289108 (+)
CAST/EiJ	MGP_CASTEiJ_G0033743	protein coding gene	Chr9:43929865-43937077 (+)
CBA/J	MGP_CBAJ_G0034393	protein coding gene	Chr9:46909499-46916646 (+)
DBA/2J	MGP_DBA2J_G0034552	protein coding gene	Chr9:42618914-42626058 (+)
FVB/NJ	MGP_FVBNJ_G0034493	protein coding gene	Chr9:41880942-41888578 (+)
LP/J	MGP_LPJ_G0034633	protein coding gene	Chr9:44268517-44275747 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034537	protein coding gene	Chr9:48708543-48715687 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035252	protein coding gene	Chr9:43534898-43542040 (+)
PWK/PhJ	MGP_PWKPhJ_G0033448	protein coding gene	Chr9:42509220-42516435 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0033284	protein coding gene	Chr9:43836162-43840329 (+)
WSB/EiJ	MGP_WSBEiJ_G0033856	protein coding gene	Chr9:43564850-43572037 (+)

Human Ortholog

FXYD2, FXYD domain containing ion transport regulator 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FXYD2, FXYD domain containing ion transport regulator 2
Synonyms

ATP1G1, HOMG2
Links

HGNC:4026

NCBI Gene ID: 486

UniProt: P54710
Chr Location

11q23.3; chr11:117800844-117828698 (-) GRCh38

MGI Vertebrate Homology

Fxyd2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FXYD2
Gene Tree

Fxyd2

Diseases

1 with human FXYD2 associations

				Human Disease	Mouse Models
				renal hypomagnesemia 2 IDs renal hypomagnesemia 2 DOID:0060885 ICD10CM:E83.4 OMIM:154020 ORDO:34528

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
8 phenotype references

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Find Mice (IMSR)

10 strains or lines available

Homozygous null mice are viable and fertile but display abnormal renal NaK-ATPase kinetics.

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All GO Annotations

35
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

853
Tissues

82
cDNA Data

194
Literature Summary

8

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fxyd2

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All Sequences

68
RefSeq

7
UniProt

8
CCDS

CCDS23134.1

Ensembl

ENSMUSG00000059412 (Evidence)
NCBI Gene

11936

			Length	Strain/Species	Flank
genomic	11936	NCBI Gene Model \| MGI Sequence Detail	10570	C57BL/6J	± kb
transcript	NM_001404664	RefSeq \| MGI Sequence Detail	1076	C57BL/6
polypeptide	Q04646	UniProt \| EBI \| MGI Sequence Detail	70	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000007714 sodium/potassium-transporting ATPase subunit gamma

(term hierarchy)
InterPro Domains

IPR000272 Ion-transport regulator, FXYD family

IPR047297 Ion-transport regulator, FXYD motif

IPR047282 Sodium/potassium-transporting ATPase subunit gamma

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All nucleic 199

cDNA 195

Primer pair 4

Microarray probesets 5

Summaries

All 49

Developmental Gene Expression 8

Gene Ontology 11

Phenotypes 8
Earliest

J:39176 Mercer RW, et al., Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase. J Cell Biol. 1993 May;121(3):579-86
Latest

J:336270 Chernova I, et al., The ion transporter Na(+)-K(+)-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Sci Adv. 2023 Feb 3;9(5):eadf8156

TSS for Fxyd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr84781	Chr9:45310954-45310967 (+)	-46 bp
Tssr84782	Chr9:45311000-45311016 (+)	1 bp
Tssr84783	Chr9:45313863-45313872 (+)	2,861 bp
Tssr84784	Chr9:45313913-45313924 (+)	2,912 bp
Tssr84785	Chr9:45314440-45314456 (+)	3,441 bp
Tssr84786	Chr9:45314472-45314487 (+)	3,473 bp
Tssr84787	Chr9:45314494-45314508 (+)	3,494 bp
Tssr84788	Chr9:45314525-45314539 (+)	3,525 bp
Tssr84789	Chr9:45314551-45314566 (+)	3,552 bp
Tssr84790	Chr9:45317233-45317307 (+)	6,263 bp
Tssr84791	Chr9:45317364-45317407 (+)	6,379 bp
Tssr84792	Chr9:45317412-45317416 (+)	6,407 bp
Tssr84793	Chr9:45318417-45318427 (+)	7,415 bp
Tssr84794	Chr9:45319566-45319608 (+)	8,580 bp
Tssr84795	Chr9:45321282-45321366 (+)	10,317 bp
Tssr84796	Chr9:45321373-45321384 (+)	10,372 bp
Tssr84797	Chr9:45321402-45321423 (+)	10,406 bp
Tssr84798	Chr9:45321426-45321467 (+)	10,440 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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