Fxyd2
Gene Detail

Symbol Name ID

Fxyd2 FXYD domain-containing ion transport regulator 2 MGI:1195260

Synonyms

Atp1g1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

24.84 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:45403138-45410278 bp, + strand From Ensembl annotation of GRCm38   7141 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:86992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Fxyd2

Human homologs

Human Homolog		FXYD2, FXYD domain containing ion transport regulator 2
NCBI Gene ID		486
neXtProt AC		NX_P54710
Human Synonyms		ATP1G1, HOMG2
Human Chr (Location)		11q23; chr11:117690790-117699408 (-)  GRCh37.p13
Disease Associations		(1) Diseases Associated with Human FXYD2

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous null mice are viable and fertile but display abnormal renal NaK-ATPase kinetics.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	ion transport, potassium ion transport, ...
Component	basolateral plasma membrane, extracellular vesicular exosome, ...
Function	ion channel activity, sodium:potassium-exchanging ATPase activity

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (148)    Tissues (77)    Images (18)
Theiler Stages: 1, 2, 3, 4, 5, 21, 23, 25, 26, 28

Assay Type	Results
RNA in situ	73
RT-PCR	75

cDNA source data(193)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(197) cDNA(194) Primer pair(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000059412 (Evidence)
Entrez Gene	11936 (Evidence)
UniGene	22742
DFCI	TC1575324, TC1581940, TC1627336, TC1640686
DoTS	DT.101240087, DT.101272173, DT.101355523, DT.536389, DT.101375757, DT.94380982
NIA Mouse Gene Index	U010415
Consensus CDS Project	CCDS23134.1
International Mouse Knockout Project Status	Fxyd2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000059412	Ensembl Gene Model | MGI Sequence Detail	7141	C57BL/6J
transcript	ENSMUST00000041005	Ensembl | MGI Sequence Detail	632	Not Applicable
polypeptide	ENSMUSP00000035429	Ensembl | MGI Sequence Detail	64	Not Applicable

All sequences(41) RefSeq(7) UniProt(4)

Polymorphisms

SNPs within 2kb(167 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000272	Ion-transport regulator, FXYD motif
Protein Ontology	PR:000007714	sodium/potassium-transporting ATPase gamma chain

References

(Earliest) J:39176 Mercer RW, et al., Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase. J Cell Biol. 1993 May;121(3):579-86
(Latest) J:196889 Arystarkhova E, et al., Hyperplasia of pancreatic beta cells and improved glucose tolerance in mice deficient in the FXYD2 subunit of Na,K-ATPase. J Biol Chem. 2013 Mar 8;288(10):7077-85
All references(42)