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Fxyd2 Gene Detail
Summary
  • Symbol
    Fxyd2
  • Name
    FXYD domain-containing ion transport regulator 2
  • Synonyms
    Atp1g1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195260
    NCBI Gene: 11936
  • Alliance
    genome feature page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:45311007-45321576 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    420 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195260
 protein coding gene Chr9:45310967-45321576 (+)
129S1/SvImJ ENSMUSG00200018058
 protein coding gene Chr9:42393236-42400372 (+)
A/J ENSMUSG00195018390
 protein coding gene Chr9:42160961-42168041 (+)
AKR/J ENSMUSG00220033777
 protein coding gene Chr9:42238718-42245774 (+)
BALB/cJ ENSMUSG00180028388
 protein coding gene Chr9:42272648-42279724 (+)
C3H/HeJ ENSMUSG00175012390
 protein coding gene Chr9:42284559-42291637 (+)
C57BL/6NJ ENSMUSG00215017618
 protein coding gene Chr9:42234588-42241665 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032145
 protein coding gene Chr9:42281967-42289108 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210015884
 protein coding gene Chr9:42321405-42328457 (+)
DBA/2J ENSMUSG00185011353
 protein coding gene Chr9:42399234-42406314 (+)
FVB/NJ ENSMUSG00205025467
 protein coding gene Chr9:42638481-42645563 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230037213
 protein coding gene Chr9:42683595-42690731 (+)
NOD/ShiLtJ ENSMUSG00190018152
 protein coding gene Chr9:42477946-42485026 (+)
NZO/HlLtJ ENSMUSG00225041675
 protein coding gene Chr9:42652134-42659214 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    FXYD2, FXYD domain containing ion transport regulator 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FXYD2, FXYD domain containing ion transport regulator 2
  • Synonyms
    ATP1G1, HOMG2
  • Links
    NCBI Gene ID: 486
    UniProt: P54710

  • Chr Location
    11q23.3; chr11:117800839-117828698 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human FXYD2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Homozygous null mice are viable and fertile but display abnormal renal NaK-ATPase kinetics.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    82
  • cDNA Data
    194
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11936 NCBI Gene Model | MGI Sequence Detail 10570 C57BL/6J ±  kb
transcript NM_001404664 RefSeq | MGI Sequence Detail 1076 C57BL/6  
polypeptide Q04646 UniProt | EBI | MGI Sequence Detail 70 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007714 sodium/potassium-transporting ATPase subunit gamma
    (term hierarchy)
  • InterPro Domains
    IPR000272 Ion-transport regulator, FXYD family
    IPR047297 Ion-transport regulator, FXYD motif
    IPR047282 Sodium/potassium-transporting ATPase subunit gamma
Molecular
Reagents
less
  • All nucleic 199
    cDNA 195
    Primer pair 4
    Antibodies 1

    Microarray probesets 5
References
more
  • Summaries
    All 52
    Developmental Gene Expression 8
    Gene Ontology 9
    Phenotypes 10
  • Earliest
    J:39176 Mercer RW, et al., Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase. J Cell Biol. 1993 May;121(3):579-86
  • Latest
    J:336270 Chernova I, et al., The ion transporter Na(+)-K(+)-ATPase enables pathological B cell survival in the kidney microenvironment of lupus nephritis. Sci Adv. 2023 Feb 3;9(5):eadf8156
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory