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Fxyd2 Gene Detail
Summary
  • Symbol
    Fxyd2
  • Name
    FXYD domain-containing ion transport regulator 2
  • Synonyms
    Atp1g1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195260
    NCBI Gene: 11936
  • Gene Overview
    MyGene.info: FXYD2
Location & Maps
more
  • Sequence Map
    Chr9:45403138-45410278 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      7141 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    FXYD2, FXYD domain containing ion transport regulator 2
  • Human Ortholog
    FXYD2, FXYD domain containing ion transport regulator 2
    Orthology source: HGNC
  • Synonyms
    ATP1G1, HOMG2
  • Links
    NCBI Gene ID: 486
    neXtProt AC: NX_P54710

  • Chr Location
    11q23; chr11:117820075-117828092 (-)  GRCh38.p2
  • HCOP
    human homology predictions: FXYD2
  • Gene Tree
    Fxyd2
Human Diseases
more
  • Diseases
    1 with human FXYD2 associations

Human Disease Mouse Models
       Hypomagnesemia 2, Renal; HOMG2   OMIM: 154020
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
  • All Mutations and Alleles
    6
  • Targeted
    6
Homozygous null mice are viable and fertile but display abnormal renal NaK-ATPase kinetics.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    130
  • Tissues
    73
  • cDNA Data
    193
  • Literature Summary
    8
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059412 Ensembl Gene Model | MGI Sequence Detail 7141 C57BL/6J ±  kb
transcript ENSMUST00000041005 Ensembl | MGI Sequence Detail 632 Not Applicable  
polypeptide ENSMUSP00000035429 Ensembl | MGI Sequence Detail 64 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    167 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000007714 sodium/potassium-transporting ATPase subunit gamma
  • InterPro Domains
    IPR000272 Ion-transport regulator, FXYD motif
Molecular
Reagents
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  • All nucleic 197
    cDNA 194
    Primer pair 3

    Microarray probesets 5
References
more
  • Summaries
    All 36
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:39176 Mercer RW, et al., Molecular cloning and immunological characterization of the gamma polypeptide, a small protein associated with the Na,K-ATPase. J Cell Biol. 1993 May;121(3):579-86
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory