Cd180 Gene Detail

Summary

• Symbol
  Cd180
• Name
  CD180 antigen
• Synonyms
  Ly78, RP105

• Feature Type
  protein coding gene
• IDs
  MGI:1194924
  NCBI Gene: 17079
• Gene Overview
  MyGene.info: CD180

Location & Maps

• Sequence Map
  Chr13:102693558-102739629 bp, + strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    46072 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 13, 54.92 cM
• Mapping Data
  4 experiments

Homology

• Human Ortholog
  CD180, CD180 molecule

• Vertebrate Orthologs
  11

• Human Ortholog
  CD180, CD180 molecule
  Orthology source: HomoloGene, HGNC
• Synonyms
  LY64, Ly78, RP105
• Links
  HGNC:6726

  NCBI Gene ID: 4064

  neXtProt AC: NX_Q99467

  UniProt: Q99467

  
  
• Chr Location
  5q12.3; chr5:67182275-67196789 (-)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 4077
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: CD180
• Protein SuperFamily
  CD180 antigen
• Gene Tree
  Cd180
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  4 phenotypes from 1 allele in 2 genetic backgrounds
  14 phenotypes from multigenic genotypes
  13 phenotype references
  

• All Mutations and Alleles
  5
• Targeted
  5
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  23 strains or lines available

Mice homozygous for a null mutation showed impaired proliferative and humoral immune responses of B cells to lipopolysaccharides.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  13
• GO References
  3

• External Resources
  FuncBase

Expression

• cDNA Data
  8

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  ZFIN cd180

Interactions

• Cd180 interacts with 175 markers (Mir10a, Mir10b, Mir15b, ...) View All

Sequences &
Gene Models

• All Sequences
  41
• RefSeq
  4
• UniProt
  6
• CCDS
  CCDS26741.1
• UniGene
  373974

• VEGA
  OTTMUSG00000035367 (Evidence)
• Ensembl
  ENSMUSG00000021624 (Evidence)
• NCBI Gene
  17079

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000035367	VEGA Gene Model | MGI Sequence Detail	46072	C57BL/6J
transcript	OTTMUST00000090359	VEGA | MGI Sequence Detail	2650	Not Applicable
polypeptide	OTTMUSP00000049549	VEGA | MGI Sequence Detail	661	Not Applicable

Polymorphisms

• SNPs within 2kb
  413 from dbSNP Build 142

• RFLP
  1

Protein
Information

• UniProt
  6 Sequences
• Protein Ontology
  PR:000001298 CD180 molecule
  (term hierarchy)
• PDB
  3T6Q
• InterPro Domains
  IPR000483 Cysteine-rich flanking region, C-terminal
  IPR001611 Leucine-rich repeat
  IPR032675 Leucine-rich repeat domain, L domain-like
  IPR003591 Leucine-rich repeat, typical subtype

Molecular
Reagents

• All nucleic 11

  cDNA 9

  Other 2

  
  

  Microarray probesets 3

References

• Summaries
  All 38

  Gene Ontology 3

  Phenotypes 13
• Earliest
  J:25726 Miyake K, et al., RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. J Immunol. 1995 Apr 1;154(7):3333-40
• Latest
  J:216834 Bastiaansen AJ, et al., TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model. PLoS One. 2014;9(6):e99882