Cd180 MGI Mouse Gene Detail - MGI:1194924

Symbol

Cd180
Name

CD180 antigen
Synonyms

Ly78, RP105

Feature Type

protein coding gene
IDs

MGI:1194924
NCBI Gene: 17079
Gene Overview

MyGene.info: CD180
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr13:102693547-102706631 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 54.92 cM
Mapping Data

4 experiments

SNPs within 2kb

131 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194924	protein coding gene	Chr13:102693547-102739629 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020898	protein coding gene	Chr13:104744500-104796830 (+)
A/J	MGP_AJ_G0020849	protein coding gene	Chr13:100661554-100707650 (+)
AKR/J	MGP_AKRJ_G0020824	protein coding gene	Chr13:103723783-103771728 (+)
BALB/cJ	MGP_BALBcJ_G0020849	protein coding gene	Chr13:101371245-101418250 (+)
C3H/HeJ	MGP_C3HHeJ_G0020638	protein coding gene	Chr13:103451875-103509060 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021283	protein coding gene	Chr13:107884682-107935754 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018853	protein coding gene	Chr13:96323974-96369800 (+)
CAST/EiJ	MGP_CASTEiJ_G0020157	protein coding gene	Chr13:102916123-102966448 (+)
CBA/J	MGP_CBAJ_G0020600	protein coding gene	Chr13:112116920-112172690 (+)
DBA/2J	MGP_DBA2J_G0020724	protein coding gene	Chr13:100425095-100472440 (+)
FVB/NJ	MGP_FVBNJ_G0020706	protein coding gene	Chr13:99119354-99165785 (+)
LP/J	MGP_LPJ_G0020798	protein coding gene	Chr13:104765698-104814244 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020734	protein coding gene	Chr13:112312535-112361908 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021322	protein coding gene	Chr13:103197653-103244029 (+)
PWK/PhJ	MGP_PWKPhJ_G0019910	protein coding gene	Chr13:99164298-99211808 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019732	protein coding gene	Chr13:99414137-99462998 (+)
WSB/EiJ	MGP_WSBEiJ_G0020215	protein coding gene	Chr13:103660067-103674562 (+)

Human Ortholog

CD180, CD180 molecule

Vertebrate Orthologs

11

Human Ortholog

CD180, CD180 molecule
Orthology source: HomoloGene, HGNC
Synonyms

LY64, Ly78, RP105
Links

HGNC:6726

NCBI Gene ID: 4064

neXtProt AC: NX_Q99467

UniProt: Q99467
Chr Location

5q12.3; chr5:67182275-67196789 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 4077
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CD180
Protein SuperFamily

CD180 antigen
Gene Tree

Cd180

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Phenotype Summary

4 phenotypes from 1 allele in 2 genetic backgrounds
14 phenotypes from multigenic genotypes
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available

Mice homozygous for a null mutation showed impaired proliferative and humoral immune responses of B cells to lipopolysaccharides.

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All GO Annotations

16
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

631
cDNA Data

9

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN cd180

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Cd180 interacts with 175 markers (Mir10a, Mir10b, Mir15b, ...) View All

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All Sequences

46
RefSeq

4
UniProt

6
CCDS

CCDS26741.1
UniGene

373974

Ensembl

ENSMUSG00000021624 (Evidence)
NCBI Gene

17079

			Length	Strain/Species	Flank
genomic	17079	NCBI Gene Model \| MGI Sequence Detail	13085	C57BL/6J	± kb
transcript	NM_008533	RefSeq \| MGI Sequence Detail	2326	NOD
polypeptide	Q62192	UniProt \| EBI \| MGI Sequence Detail	661	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000001298 CD180 molecule

(term hierarchy)
PDB

3T6Q
InterPro Domains

IPR041281 CD180, leucine-rich repeat

IPR000483 Cysteine-rich flanking region, C-terminal

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR017241 Toll-like receptor

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All nucleic 10

cDNA 10

Microarray probesets 3

Summaries

All 46

Gene Ontology 5

Phenotypes 17
Earliest

J:25726 Miyake K, et al., RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. J Immunol. 1995 Apr 1;154(7):3333-40
Latest

J:300847 Sakaguchi T, et al., TRPM5 Negatively Regulates Calcium-Dependent Responses in Lipopolysaccharide-Stimulated B Lymphocytes. Cell Rep. 2020 Jun 9;31(10):107755

TSS for Cd180:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr120877	Chr13:102693522-102693586 (+)	7 bp
Tssr120878	Chr13:102693596-102693607 (+)	55 bp
Tssr120879	Chr13:102693649-102693660 (+)	108 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 02/23/2021 MGI 6.16