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Cd180 Gene Detail
Summary
  • Symbol
    Cd180
  • Name
    CD180 antigen
  • Synonyms
    Ly78, RP105
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194924
    NCBI Gene: 17079
  • Gene Overview
    MyGene.info: CD180
Location & Maps
more
  • Sequence Map
    Chr13:102693558-102739629 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      46072 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 54.92 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CD180, CD180 molecule
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CD180, CD180 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LY64, Ly78, RP105
  • Links
    NCBI Gene ID: 4064
    neXtProt AC: NX_Q99467

  • Chr Location
    5q12; chr5:67181009-67196789 (-)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation showed impaired proliferative and humoral immune responses of B cells to lipopolysaccharides.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
    8
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035367 VEGA Gene Model | MGI Sequence Detail 46072 C57BL/6J ±  kb
transcript OTTMUST00000090359 VEGA | MGI Sequence Detail 2650 Not Applicable  
polypeptide OTTMUSP00000049549 VEGA | MGI Sequence Detail 661 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    413 from dbSNP Build 142
  • RFLP
    1
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000001298 CD180 molecule
  • PDB
    3T6Q
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 11
    cDNA 9
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:25726 Miyake K, et al., RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. J Immunol. 1995 Apr 1;154(7):3333-40
  • Latest
    J:216834 Bastiaansen AJ, et al., TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model. PLoS One. 2014;9(6):e99882
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory