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Ttk Gene Detail
Summary
  • Symbol
    Ttk
  • Name
    Ttk protein kinase
  • Synonyms
    Esk1, Mps1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194921
    NCBI Gene: 22137
  • Gene Overview
    MyGene.info: TTK
Location & Maps
more
  • Sequence Map
    Chr9:83834689-83872389 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37701 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 45.61 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TTK, TTK protein kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TTK, TTK protein kinase
    Orthology source: HomoloGene
  • Synonyms
    CT96, ESK, MPH1, MPS1, MPS1L1, PYT
  • Links
    NCBI Gene ID: 7272
    neXtProt AC: NX_P33981

  • Chr Location
    6q14.1; chr6:80004605-80042527 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2489
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: TTK
  • Gene Tree
    Ttk
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    16
  • Targeted
    2
  • Genomic Mutations
    1 involving Ttk
  • Incidental Mutations
Mice homozygous for a floxed allele activated in oocytes exhibit reduced female fertility associated with defective spindle assembly checkpoint, premature chromosome segregation, and accelerated anaphase and polar body extrusion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044947 VEGA Gene Model | MGI Sequence Detail 37701 C57BL/6J ±  kb
transcript OTTMUST00000118126 VEGA | MGI Sequence Detail 2871 Not Applicable  
polypeptide OTTMUSP00000065963 VEGA | MGI Sequence Detail 830 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    490 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000016787 dual specificity protein kinase TTK
  • EC
  • InterPro Domains
    IPR027084 Dual specificity protein kinase TTK
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR011990 Tetratricopeptide-like helical domain
Molecular
Reagents
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  • All nucleic 68
    cDNA 68

    Microarray probesets 4
Other
Accession IDs
less
MGI:2143170
References
more
  • Summaries
    All 34
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:43402 Douville EM, et al., Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms. Mol Cell Biol. 1992 Jun;12(6):2681-9
  • Latest
    J:222693 Touati SA, et al., Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest. Nat Commun. 2015;6:6946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory