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Ttk Gene Detail
Summary
  • Symbol
    Ttk
  • Name
    Ttk protein kinase
  • Synonyms
    Esk1, Mps1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194921
    NCBI Gene: 22137
  • Gene Overview
    MyGene.info: TTK
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:83834689-83872389 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37701 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 45.61 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TTK, TTK protein kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TTK, TTK protein kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CT96, ESK, MPH1, MPS1, MPS1L1, PYT
  • Links
    NCBI Gene ID: 7272
    neXtProt AC: NX_P33981
    UniProt: P33981

  • Chr Location
    6q14.1; chr6:80004147-80043577 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2489
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TTK
  • Gene Tree
    Ttk
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a floxed allele activated in oocytes exhibit reduced female fertility associated with defective spindle assembly checkpoint, premature chromosome segregation, and accelerated anaphase and polar body extrusion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000044947 VEGA Gene Model | MGI Sequence Detail 37701 C57BL/6J ±  kb
    transcript OTTMUST00000118126 VEGA | MGI Sequence Detail 2871 Not Applicable  
    polypeptide OTTMUSP00000065963 VEGA | MGI Sequence Detail 830 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      490 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 69
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143170
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:43402 Douville EM, et al., Multiple cDNAs encoding the esk kinase predict transmembrane and intracellular enzyme isoforms. Mol Cell Biol. 1992 Jun;12(6):2681-9
    • Latest
      J:243411 Rutledge EA, et al., Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Development. 2017 Sep 01;144(17):3177-3188

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory