Asic1 MGI Mouse Gene Detail - MGI:1194915 - acid-sensing (proton-gated) ion channel 1

Symbol

Asic1
Name

acid-sensing (proton-gated) ion channel 1
Synonyms

Accn2, ASIC, ASIC1a, ASIC1 beta, ASICalpha, B530003N02Rik, BNaC2

Feature Type

protein coding gene
IDs

MGI:1194915
NCBI Gene: 11419
Gene Overview

MyGene.info: ASIC1
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:99670368-99701130 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.13 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

145 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194915	protein coding gene	Chr15:99670197-99701130 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022338	protein coding gene	Chr15:101537898-101572479 (+)
A/J	MGP_AJ_G0022296	protein coding gene	Chr15:97485712-97516100 (+)
AKR/J	MGP_AKRJ_G0022272	protein coding gene	Chr15:100485756-100517910 (+)
BALB/cJ	MGP_BALBcJ_G0022302	protein coding gene	Chr15:97670968-97703012 (+)
C3H/HeJ	MGP_C3HHeJ_G0022070	protein coding gene	Chr15:100554412-100585869 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022747	protein coding gene	Chr15:105325362-105357284 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020273	protein coding gene	Chr15:93379258-93410441 (+)
CAST/EiJ	MGP_CASTEiJ_G0021594	protein coding gene	Chr15:101423683-101456164 (+)
CBA/J	MGP_CBAJ_G0022039	protein coding gene	Chr15:108916120-108952921 (+)
DBA/2J	MGP_DBA2J_G0022166	protein coding gene	Chr15:96921316-96953945 (+)
FVB/NJ	MGP_FVBNJ_G0022146	protein coding gene	Chr15:95913053-95945188 (+)
LP/J	MGP_LPJ_G0022237	protein coding gene	Chr15:101683610-101720009 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022166	protein coding gene	Chr15:112801077-112834632 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022762	protein coding gene	Chr15:100600759-100637025 (+)
PWK/PhJ	MGP_PWKPhJ_G0021333	protein coding gene	Chr15:97065531-97097526 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021168	protein coding gene	Chr15:100446315-100479086 (+)
WSB/EiJ	MGP_WSBEiJ_G0021645	protein coding gene	Chr15:101118761-101152024 (+)

Human Ortholog

ASIC1, acid sensing ion channel subunit 1

Vertebrate Orthologs

10

Human Ortholog

ASIC1, acid sensing ion channel subunit 1
Orthology source: HomoloGene, HGNC
Synonyms

ACCN2, ASIC, BNaC2
Links

HGNC:100

NCBI Gene ID: 41

neXtProt AC: NX_P78348

UniProt: P78348
Chr Location

12q13.12; chr12:50057637-50083622 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 121755
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ASIC1
Gene Tree

Asic1

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
78 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

19
Radiation induced

2
Targeted

3
Transgenic

1
Genomic Mutations

3 involving Asic1
Incidental Mutations

APF
Find Mice (IMSR)

5 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene results in absence of H⁺-gated currents in hippocampal neurons, impaired long term potentiation, reduced excitatory postsynaptic potentials, and defective spatial learning and eye blink conditioning.

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All GO Annotations

47
GO References

15

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

660
Tissues

24
cDNA Data

37
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase asic1

ZFIN asic1a, asic1b

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Asic1 interacts with 324 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

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All Sequences

51
RefSeq

10
UniProt

3
CCDS

CCDS27826.1, CCDS88841.1
UniGene

440107

Ensembl

ENSMUSG00000023017 (Evidence)
NCBI Gene

11419

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023017	Ensembl Gene Model \| MGI Sequence Detail	30763	C57BL/6J	± kb
transcript	ENSMUST00000228185	Ensembl \| MGI Sequence Detail	1818	Not Applicable
polypeptide	ENSMUSP00000154379	Ensembl \| MGI Sequence Detail	559	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003615 acid-sensing ion channel 1

(term hierarchy)
InterPro Domains

IPR001873 Epithelial sodium channel

IPR004724 Epithelial sodium channel, chordates

IPR020903 Epithelial sodium channel, conserved site

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All nucleic 37

cDNA 37

Microarray probesets 4

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MGI:2146072

Summaries

All 125

Developmental Gene Expression 5

Diseases 1

Gene Ontology 15

Phenotypes 78
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:283759 Wang JJ, et al., Disruption of auto-inhibition underlies conformational signaling of ASIC1a to induce neuronal necroptosis. Nat Commun. 2020 Jan 24;11(1):475

TSS for Asic1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133041	Chr15:99670217-99670231 (+)	-144 bp
Tssr133042	Chr15:99670327-99670396 (+)	-6 bp
Tssr133043	Chr15:99670403-99670419 (+)	43 bp
Tssr133044	Chr15:99670574-99670634 (+)	236 bp
Tssr4713	Chr15:99671115-99671123 (+)	751 bp
Tssr4714	Chr15:99692189-99692199 (+)	21,826 bp
Tssr133045	Chr15:99692218-99692229 (+)	21,856 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 06/23/2020 MGI 6.15