About   Help   FAQ
Asic1
Gene Detail
 Symbol
Name
ID
Asic1
acid-sensing (proton-gated) ion channel 1
MGI:1194915
Synonyms Accn2, ASIC, ASIC1a, ASIC1 beta, ASICalpha, B530003N02Rik, BNaC2
Feature Type protein coding gene
Genetic Map
Chromosome 15
56.13 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:99670718-99701127 bp, + strand
From Ensembl annotation of GRCm38

  30410 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Asic1

Human
homologs
Human Homolog ASIC1, acid-sensing (proton-gated) ion channel 1
NCBI Gene ID 41
neXtProt AC  NX_P78348
Human Synonyms  ACCN2, ASIC, BNaC2
Human Chr (Location)  12q12; chr12:50057637-50083622 (+)  GRCh38
Alleles
and
phenotypes
All alleles(21) : Gene trapped(19) Targeted(2)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in absence of H+-gated currents in hippocampal neurons, impaired long term potentiation, reduced excitatory postsynaptic potentials, and defective spatial learning and eye blink conditioning.
 
Gene Ontology
(GO)
classifications
All GO classifications: (43 annotations)
Process associative learning, calcium ion transmembrane transport, ...
Component cell surface, dendritic shaft, ...
Function acid-sensing ion channel activity, cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (22)    Tissues (19)    Images (3)
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
RNA in situ 18
Northern blot 4
cDNA source data(36)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000023017 (Evidence)
Entrez Gene11419 (Evidence)
UniGene440107
DFCITC1581166, TC1651938
DoTSDT.103563629, DT.527280, DT.91356982
NIA Mouse Gene IndexU016645
Consensus CDS ProjectCCDS27826.1
International Mouse Knockout Project StatusAsic1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023017 Ensembl Gene Model | MGI Sequence Detail 30410 C57BL/6J ±  kb
transcript ENSMUST00000023758 Ensembl | MGI Sequence Detail 3763 Not Applicable 
polypeptide ENSMUSP00000023758 Ensembl | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(10) UniProt(3)
Polymorphisms SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004724 Epithelial sodium channel
InterPro IPR001873 Na+ channel, amiloride-sensitive
InterPro IPR020903 Na+ channel, amiloride-sensitive, conserved site
Protein Ontology PR:000003615 acid-sensing ion channel 1
References (Earliest) J:44643 Garcia-Anoveros J, et al., BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1459-64
(Latest) J:207694 Nitta CH, et al., Role of ASIC1 in the development of chronic hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol. 2014 Jan 1;306(1):H41-52
All references(64)
Other
accession IDs
MGI:2146072

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory