Asic1 MGI Mouse Gene Detail - MGI:1194915 - acid-sensing (proton-gated) ion channel 1

Asic1 Gene Detail

Symbol

Asic1
Name

acid-sensing (proton-gated) ion channel 1
Synonyms

Accn2, ASIC, ASIC1a, ASIC1 beta, ASICalpha, B530003N02Rik, BNaC2

Feature Type

protein coding gene
IDs

MGI:1194915
NCBI Gene: 11419
Gene Overview

MyGene.info: ASIC1

Sequence Map

Chr15:99670718-99701127 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

30410 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.13 cM, cytoband F3
Mapping Data

3 experiments

Human Ortholog

ASIC1, acid sensing ion channel subunit 1

Vertebrate Orthologs

10

Human Ortholog

ASIC1, acid sensing ion channel subunit 1
Orthology source: HomoloGene, HGNC
Synonyms

ACCN2, ASIC, BNaC2
Links

HGNC:100

NCBI Gene ID: 41

neXtProt AC: NX_P78348

UniProt: P78348
Chr Location

12q13.12; chr12:50057637-50083622 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 121755
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ASIC1
Gene Tree

Asic1

less

References

1 with disease annotations

less

Phenotype Summary

9 phenotypes from 2 alleles in 2 genetic backgrounds
57 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Chemically induced (other)

1
Gene trapped

19
Radiation induced

2
Targeted

3
Transgenic

1
Genomic Mutations

3 involving Asic1
Incidental Mutations

APF
Find Mice (IMSR)

23 strains or lines available

Homozygous mutation of this gene results in absence of H⁺-gated currents in hippocampal neurons, impaired long term potentiation, reduced excitatory postsynaptic potentials, and defective spatial learning and eye blink conditioning.

less

All GO Annotations

45
GO References

13

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

22
Tissues

19
cDNA Data

36
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase asic1

ZFIN asic1a, asic1b

less

Asic1 interacts with 324 markers (Mir9-1, Mir9-2, Mir9-3, ...) View All

less

All Sequences

27
RefSeq

12
UniProt

3
CCDS

CCDS27826.1
UniGene

440107

Ensembl

ENSMUSG00000023017 (Evidence)
NCBI Gene

11419

			Length	Strain/Species	Flank
genomic	ENSMUSG00000023017	Ensembl Gene Model \| MGI Sequence Detail	30410	C57BL/6J	± kb
transcript	ENSMUST00000023758	Ensembl \| MGI Sequence Detail	3763	Not Applicable
polypeptide	ENSMUSP00000023758	Ensembl \| MGI Sequence Detail	526	Not Applicable

less

SNPs within 2kb

145 from dbSNP Build 142

less

UniProt

3 Sequences
Protein Ontology

PR:000003615 acid-sensing ion channel 1

(term hierarchy)
InterPro Domains

IPR001873 Epithelial sodium channel

IPR004724 Epithelial sodium channel, chordates

IPR020903 Epithelial sodium channel, conserved site

less

All nucleic 36

cDNA 36

Microarray probesets 4

less

MGI:2146072

Summaries

All 93

Developmental Gene Expression 4

Diseases 1

Gene Ontology 13

Phenotypes 57
Earliest

J:13437 Bangham JW, Hairy ears, Eh. Mouse News Lett. 1965;33:68
Latest

J:239681 Gonzalez-Inchauspe C, et al., Acid-Sensing Ion Channels Activated by Evoked Released Protons Modulate Synaptic Transmission at the Mouse Calyx of Held Synapse. J Neurosci. 2017 Mar 08;37(10):2589-2599

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 07/11/2017 MGI 6.10