Asic1
Gene Detail

Symbol

Name
ID

Asic1
acid-sensing (proton-gated) ion channel 1
MGI:1194915

Synonyms

Accn2, ASIC, ASIC1a, ASIC1 beta, ASICalpha, B530003N02Rik, BNaC2

Feature Type

protein coding gene

Genetic Map

Chromosome 15
56.13 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:99670718-99701127 bp, + strand From Ensembl annotation of GRCm38   30410 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:121755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Asic1

Human
homologs

Human Homolog		ASIC1, acid-sensing (proton-gated) ion channel 1
NCBI Gene ID		41
neXtProt AC		NX_P78348
Human Synonyms		ACCN2, ASIC, BNaC2
Human Chr (Location)		12q12; chr12:50057637-50083622 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(23) : Gene trapped(19) Radiation induced(1) Targeted(2) Transgenic(1)
Genomic Mutations involving Asic1 (1)
Incidental mutations (data from APF )
 

Homozygous mutation of this gene results in absence of H⁺-gated currents in hippocampal neurons, impaired long term potentiation, reduced excitatory postsynaptic potentials, and defective spatial learning and eye blink conditioning.

 
Phenotype Images(2)

Interactions

Asic1 interacts with 325 markers (Mir9-1, Mir9-2, Mir9-3, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (44 annotations)

Process	associative learning, calcium ion transmembrane transport, ...
Component	cell surface, dendritic shaft, ...
Function	acid-sensing ion channel activity, cation channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (22)    Tissues (19)    Images (3)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	18
Northern blot	4

cDNA source data(36)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(36) cDNA(36)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000023017 (Evidence)
Entrez Gene	11419 (Evidence)
UniGene	440107
DFCI	TC1651938, TC1581166
DoTS	DT.91356982, DT.103563629, DT.527280
NIA Mouse Gene Index	U016645
Consensus CDS Project	CCDS27826.1
International Mouse Knockout Project Status	Asic1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000023017	Ensembl Gene Model | MGI Sequence Detail	30410	C57BL/6J
transcript	ENSMUST00000023758	Ensembl | MGI Sequence Detail	3763	Not Applicable
polypeptide	ENSMUSP00000023758	Ensembl | MGI Sequence Detail	526	Not Applicable

All sequences(33) RefSeq(10) UniProt(5)

Polymorphisms

SNPs within 2kb(149 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004724	Epithelial sodium channel
InterPro	IPR001873	Na+ channel, amiloride-sensitive
InterPro	IPR020903	Na+ channel, amiloride-sensitive, conserved site
Protein Ontology	PR:000003615	acid-sensing ion channel 1

References

(Earliest) J:44643 Garcia-Anoveros J, et al., BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1459-64
(Latest) J:211633 Du J, et al., Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8961-6
All references(66)

Other
accession IDs

MGI:2146072