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Asic1 Gene Detail
Summary
  • Symbol
    Asic1
  • Name
    acid-sensing (proton-gated) ion channel 1
  • Synonyms
    Accn2, ASIC, ASIC1a, ASIC1 beta, ASICalpha, B530003N02Rik, BNaC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194915
    NCBI Gene: 11419
  • Gene Overview
    MyGene.info: ASIC1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr15:99670368-99701130 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      30763 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.13 cM, cytoband F3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ASIC1, acid sensing ion channel subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ASIC1, acid sensing ion channel subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACCN2, ASIC, BNaC2
  • Links
    NCBI Gene ID: 41
    neXtProt AC: NX_P78348
    UniProt: P78348

  • Chr Location
    12q13.12; chr12:50057637-50083622 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 121755
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ASIC1
  • Gene Tree
    Asic1
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in absence of H+-gated currents in hippocampal neurons, impaired long term potentiation, reduced excitatory postsynaptic potentials, and defective spatial learning and eye blink conditioning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    29
  • Tissues
    24
  • cDNA Data
    37
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023017 Ensembl Gene Model | MGI Sequence Detail 30763 C57BL/6J ±  kb
    transcript ENSMUST00000228185 Ensembl | MGI Sequence Detail 1818 Not Applicable  
    polypeptide ENSMUSP00000154379 Ensembl | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      145 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146072
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 15
      Phenotypes 67
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:265057 Gregory NS, et al., Acid Sensing Ion Channel 1a (ASIC1a) Mediates Activity-induced Pain by Modulation of Heteromeric ASIC Channel Kinetics. Neuroscience. 2018 Aug 21;386:166-174
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/16/2018
    MGI 6.12     		The Jackson Laboratory