About   Help   FAQ
Asic1
Gene Detail
Symbol

Name
ID
Asic1
acid-sensing (proton-gated) ion channel 1
MGI:1194915
Synonyms
Accn2, ASIC, ASIC1a, ASIC1 beta, ASICalpha, B530003N02Rik, BNaC2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.13 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:99670718-99701127 bp, + strand
From Ensembl annotation of GRCm38

  30410 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121755  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ASIC1
Gene Tree: Asic1

Human
homologs
ASIC1, acid sensing (proton gated) ion channel 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 41
neXtProt AC: NX_P78348

Human Synonyms: ACCN2, ASIC, BNaC2

Human Chr (Location): 12q12; chr12:50057637-50083622 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(19) Radiation induced(1) Targeted(2) Transgenic(1)
Genomic Mutations involving Asic1 (1)
Incidental mutations (data from APF )
 
Homozygous mutation of this gene results in absence of H+-gated currents in hippocampal neurons, impaired long term potentiation, reduced excitatory postsynaptic potentials, and defective spatial learning and eye blink conditioning.
 
Phenotype Images(2)
Interactions
Asic1 interacts with 324 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process associative learning, calcium ion transmembrane transport, ...
Component cell surface, dendritic shaft, ...
Function acid-sensing ion channel activity, cation channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (22)    Tissues (19)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 18
Northern blot 4
cDNA source data(36)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase asic1 ; ZFIN asic1a, asic1b    NEW 
Molecular
reagents
All nucleic(36) cDNA(36)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000023017 (Evidence)
Entrez Gene 11419 (Evidence)
UniGene 440107
DFCI TC1581166, TC1651938
DoTS DT.103563629, DT.91356982, DT.527280
NIA Mouse Gene Index U016645
Consensus CDS Project CCDS27826.1
International Mouse Phenotyping Consortium Status Asic1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023017 Ensembl Gene Model | MGI Sequence Detail 30410 C57BL/6J ±  kb
transcript ENSMUST00000023758 Ensembl | MGI Sequence Detail 3763 Not Applicable 
polypeptide ENSMUSP00000023758 Ensembl | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(10) UniProt(3)
Polymorphisms
SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004724 Epithelial sodium channel
InterPro IPR001873 Na+ channel, amiloride-sensitive
InterPro IPR020903 Na+ channel, amiloride-sensitive, conserved site
Protein Ontology PR:000003615 acid-sensing ion channel 1
References
(Earliest) J:44643 Garcia-Anoveros J, et al., BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1459-64
(Latest) J:220575 Price MP, et al., Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli. Genes Brain Behav. 2014 Feb;13(2):179-94
All references(67)
Other
accession IDs
MGI:2146072

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory