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Rbbp4 Gene Detail
Summary
  • Symbol
    Rbbp4
  • Name
    retinoblastoma binding protein 4
  • Synonyms
    CAF-1 p48 subunit, RBAP48
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194912
    NCBI Gene: 19646
  • Gene Overview
    MyGene.info: RBBP4
Location & Maps
more
  • Sequence Map
    Chr4:129307100-129335370 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28271 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RBBP4, retinoblastoma binding protein 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RBBP4, retinoblastoma binding protein 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    lin-53, NURF55, RBAP48
  • Links
    NCBI Gene ID: 5928
    neXtProt AC: NX_Q09028

  • Chr Location
    1p35.1; chr1:32651148-32686211 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from multigenic genotypes
    15 phenotype references
  • All Mutations and Alleles
    49
  • Chemically induced (other)
    2
  • Gene trapped
    42
  • Radiation induced
    1
  • Targeted
    3
  • Transgenic
    1
  • Genomic Mutations
    4 involving Rbbp4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009619 VEGA Gene Model | MGI Sequence Detail 28271 C57BL/6J ±  kb
transcript OTTMUST00000022134 VEGA | MGI Sequence Detail 4407 Not Applicable  
polypeptide OTTMUSP00000010088 VEGA | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    291 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013776 histone-binding protein RBBP4
  • InterPro Domains
    IPR020472 G-protein beta WD-40 repeat
    IPR022052 Histone-binding protein RBBP4, N-terminal
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 15
    cDNA 13
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 6
    Phenotypes 15
  • Earliest
    J:113043 Lee EY, et al., Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 1994 Sep 1;8(17):2008-21
  • Latest
    J:222281 Balboula AZ, et al., RBBP4 regulates histone deacetylation and bipolar spindle assembly during oocyte maturation in the mouse. Biol Reprod. 2015 Apr;92(4):105

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory