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Rbbp4 Gene Detail
Summary
  • Symbol
    Rbbp4
  • Name
    retinoblastoma binding protein 4, chromatin remodeling factor
  • Synonyms
    CAF-1 p48 subunit, RBAP48
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194912
    NCBI Gene: 19646
  • Gene Overview
    MyGene.info: RBBP4
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129307100-129335370 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 63.26 cM, cytoband D2.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    291 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194912
protein coding gene Chr4:129307100-129335372 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028819
protein coding gene Chr4:131204399-131237277 (-)
A/J MGP_AJ_G0028778
protein coding gene Chr4:125981618-126009933 (-)
AKR/J MGP_AKRJ_G0028731
protein coding gene Chr4:129482431-129511808 (-)
BALB/cJ MGP_BALBcJ_G0028801
protein coding gene Chr4:126573739-126601350 (-)
C3H/HeJ MGP_C3HHeJ_G0028515
protein coding gene Chr4:129535213-129565519 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029243
protein coding gene Chr4:136153902-136184475 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026516
protein coding gene Chr4:119111063-119140140 (-)
CAST/EiJ MGP_CASTEiJ_G0027948
protein coding gene Chr4:127717157-127748184 (-)
CBA/J MGP_CBAJ_G0028481
protein coding gene Chr4:139467475-139497935 (-)
DBA/2J MGP_DBA2J_G0028630
protein coding gene Chr4:126412199-126440231 (-)
FVB/NJ MGP_FVBNJ_G0028597
protein coding gene Chr4:125174616-125205312 (-)
LP/J MGP_LPJ_G0028731
protein coding gene Chr4:131501128-131528422 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028623
protein coding gene Chr4:144367131-144397904 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029281
protein coding gene Chr4:129855145-129885241 (-)
PWK/PhJ MGP_PWKPhJ_G0027669
protein coding gene Chr4:122990590-123022729 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027496
protein coding gene Chr4:125717843-125746135 (-)
WSB/EiJ MGP_WSBEiJ_G0028028
protein coding gene Chr4:129970495-130000685 (-)



Homology
more
  • Human Ortholog
    RBBP4, RB binding protein 4, chromatin remodeling factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RBBP4, RB binding protein 4, chromatin remodeling factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    lin-53, NURF55, RBAP48
  • Links
    NCBI Gene ID: 5928
    neXtProt AC: NX_Q09028
    UniProt: Q09028

  • Chr Location
    1p35.1; chr1:32651148-32686211 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from multigenic genotypes
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057236 Ensembl Gene Model | MGI Sequence Detail 28271 C57BL/6J ±  kb
transcript ENSMUST00000102598 Ensembl | MGI Sequence Detail 4407 Not Applicable  
polypeptide ENSMUSP00000099658 Ensembl | MGI Sequence Detail 425 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 59
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:113043 Lee EY, et al., Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 1994 Sep 1;8(17):2008-21
  • Latest
    J:237908 Muralidharan B, et al., LHX2 Interacts with the NuRD Complex and Regulates Cortical Neuron Subtype Determinants Fezf2 and Sox11. J Neurosci. 2017 Jan 04;37(1):194-203

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory