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Rbbp4 Gene Detail
Summary
  • Symbol
    Rbbp4
  • Name
    retinoblastoma binding protein 4, chromatin remodeling factor
  • Synonyms
    CAF-1 p48 subunit, RBAP48
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194912
    NCBI Gene: 19646
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:129200893-129229163 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 63.26 cM, cytoband D2.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    291 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194912
 protein coding gene Chr4:129200893-129229163 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028819
 protein coding gene Chr4:131204399-131237277 (-)
A/J MGP_AJ_G0028778
 protein coding gene Chr4:125981618-126009933 (-)
AKR/J MGP_AKRJ_G0028731
 protein coding gene Chr4:129482431-129511808 (-)
BALB/cJ MGP_BALBcJ_G0028801
 protein coding gene Chr4:126573739-126601350 (-)
C3H/HeJ MGP_C3HHeJ_G0028515
 protein coding gene Chr4:129535213-129565519 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029243
 protein coding gene Chr4:136153902-136184475 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026516
 protein coding gene Chr4:119111063-119140140 (-)
CAST/EiJ MGP_CASTEiJ_G0027948
 protein coding gene Chr4:127717157-127748184 (-)
CBA/J MGP_CBAJ_G0028481
 protein coding gene Chr4:139467475-139497935 (-)
DBA/2J MGP_DBA2J_G0028630
 protein coding gene Chr4:126412199-126440231 (-)
FVB/NJ MGP_FVBNJ_G0028597
 protein coding gene Chr4:125174616-125205312 (-)
LP/J MGP_LPJ_G0028731
 protein coding gene Chr4:131501128-131528422 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028623
 protein coding gene Chr4:144367131-144397904 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029281
 protein coding gene Chr4:129855145-129885241 (-)
PWK/PhJ MGP_PWKPhJ_G0027669
 protein coding gene Chr4:122990590-123022729 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027496
 protein coding gene Chr4:125717843-125746135 (-)
WSB/EiJ MGP_WSBEiJ_G0028028
 protein coding gene Chr4:129970495-130000685 (-)



Homology
more
  • Human Ortholog
    RBBP4, RB binding protein 4, chromatin remodeling factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBBP4, RB binding protein 4, chromatin remodeling factor
  • Synonyms
    lin-53, NURF55, RBAP48
  • Links
    NCBI Gene ID: 5928
    neXtProt AC: NX_Q09028
    UniProt: Q09028

  • Chr Location
    1p35.1; chr1:32651142-32686211 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality between implantation and somite formation. Cultured blastocysts fail to form typical outgrowth colonies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    64
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    48
  • cDNA Data
    13
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19646 NCBI Gene Model | MGI Sequence Detail 28271 C57BL/6J ±  kb
    transcript NM_009030 RefSeq | MGI Sequence Detail 4407 C57BL/6  
    polypeptide Q60972 UniProt | EBI | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 14
      Primer pair 3
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 83
      Developmental Gene Expression 13
      Gene Ontology 23
      Phenotypes 22
    • Earliest
      J:113043 Lee EY, et al., Dual roles of the retinoblastoma protein in cell cycle regulation and neuron differentiation. Genes Dev. 1994 Sep 1;8(17):2008-21
    • Latest
      J:337199 Mu W, et al., RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression. G3 (Bethesda). 2022 May 30;12(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory