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Rbbp7
Gene Detail
Symbol

Name
ID
Rbbp7
retinoblastoma binding protein 7
MGI:1194910
Feature Type
protein coding gene
Genetic Map
Chromosome X
74.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:162760402-162779092 bp, + strand
From VEGA annotation of GRCm38

  18691 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55702  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RBBP7
Protein SuperFamily: MSI1 protein
Gene Tree: Rbbp7

Human
homologs
RBBP7, retinoblastoma binding protein 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5931
neXtProt AC: NX_Q16576

Human Synonyms: RbAp46

Human Chr (Location): Xp22.2; chrX:16844650-16870442 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(30) Targeted(1)
Incidental mutations (data from APF )
 
Male mice hemizygous for a targeted disruption of this gene exhibit decreased CD8-positive T cell number and decreased CD4-positive, alpha-beta memory T cell number. Male chimeras hemizygous for a gene trapped allele exhibit posterior patterning and embryo turning defects.
 
Phenotype Images(9)
Interactions
Rbbp7 interacts with 224 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cellular heat acclimation, chromatin modification, ...
Component ESC/E(Z) complex, nucleus, ...
Function protein binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (189)    Tissues (27)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 142
RT-PCR 36
RNase protection 11
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rbbp7    NEW 
Molecular
reagents
All nucleic(34) cDNA(32) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017256 (Evidence)
Ensembl Gene Model ENSMUSG00000031353 (Evidence)
Entrez Gene 245688 (Evidence)
DFCI TC1573711, TC1717267
NIA Mouse Gene Index U059869, U020375
Consensus CDS Project CCDS30509.1
International Mouse Phenotyping Consortium Status Rbbp7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017256 VEGA Gene Model | MGI Sequence Detail 18691 C57BL/6J ±  kb
transcript OTTMUST00000041756 VEGA | MGI Sequence Detail 2244 Not Applicable 
polypeptide OTTMUSP00000018766 VEGA | MGI Sequence Detail 425 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(2) UniProt(8)
Polymorphisms
RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)    SNPs within 2kb including multiple locations(29)
Protein-related
information
ResourceIDDescription
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR022052 Histone-binding protein RBBP4
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000013779 histone-binding protein RBBP7
References
(Earliest) J:43395 Qian YW, et al., Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. J Biol Chem. 1995 Oct 27;270(43):25507-13
(Latest) J:188128 Shore AN, et al., Pregnancy-induced noncoding RNA (PINC) associates with polycomb repressive complex 2 and regulates mammary epithelial differentiation. PLoS Genet. 2012 Jul;8(7):e1002840
All references(47)
Other
accession IDs
MGI:2147827, MGI:2147849, MGI:2147961, MGI:2148033

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory