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Rbbp7 Gene Detail
Summary
  • Symbol
    Rbbp7
  • Name
    retinoblastoma binding protein 7, chromatin remodeling factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194910
    NCBI Gene: 245688
  • Gene Overview
    MyGene.info: RBBP7
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:162760402-162779092 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 74.97 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194910
protein coding gene ChrX:162760372-162779092 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036240
protein coding gene ChrX:160775712-160795912 (+)
A/J MGP_AJ_G0036210
protein coding gene ChrX:159994354-160013330 (+)
AKR/J MGP_AKRJ_G0036138
protein coding gene ChrX:165075560-165106497 (+)
BALB/cJ MGP_BALBcJ_G0036203
protein coding gene ChrX:157993257-158012016 (+)
C3H/HeJ MGP_C3HHeJ_G0035909
protein coding gene ChrX:161150790-161169957 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036725
protein coding gene ChrX:165517139-165536231 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033547
protein coding gene ChrX:151084588-151102178 (+)
CAST/EiJ MGP_CASTEiJ_G0035198
protein coding gene ChrX:140129738-140148553 (+)
CBA/J MGP_CBAJ_G0035884
protein coding gene ChrX:170259954-170279679 (+)
DBA/2J MGP_DBA2J_G0036050
protein coding gene ChrX:158896941-158915349 (+)
FVB/NJ MGP_FVBNJ_G0035981
protein coding gene ChrX:158031106-158050220 (+)
LP/J MGP_LPJ_G0036135
protein coding gene ChrX:161960726-161979129 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036013
protein coding gene ChrX:178954420-178973518 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036766
protein coding gene ChrX:160284419-160302741 (+)
PWK/PhJ MGP_PWKPhJ_G0034896
protein coding gene ChrX:136943128-136962508 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034717
protein coding gene ChrX:140598282-140618574 (+)
WSB/EiJ MGP_WSBEiJ_G0035333
protein coding gene ChrX:158253275-158271728 (+)



Homology
more
  • Human Ortholog
    RBBP7, RB binding protein 7, chromatin remodeling factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RBBP7, RB binding protein 7, chromatin remodeling factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RbAp46
  • Links
    NCBI Gene ID: 5931
    neXtProt AC: NX_Q16576
    UniProt: Q16576

  • Chr Location
    Xp22.2; chrX:16844650-16870411 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    9 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male chimeras hemizygous for a gene trapped allele exhibit posterior patterning and embryo turning defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031353 Ensembl Gene Model | MGI Sequence Detail 18691 C57BL/6J ±  kb
    transcript ENSMUST00000033720 Ensembl | MGI Sequence Detail 2244 Not Applicable  
    polypeptide ENSMUSP00000033720 Ensembl | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 33
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2147827, MGI:2147849, MGI:2147961, MGI:2148033
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:43395 Qian YW, et al., Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast. J Biol Chem. 1995 Oct 27;270(43):25507-13
    • Latest
      J:249035 Kannan M, et al., WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9308-E9317

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory