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Rsph1
Gene Detail
 Symbol
Name
ID
Rsph1
radial spoke head 1 homolog (Chlamydomonas)
MGI:1194909
Synonyms MCA, meichroacidin, Tsga2
Feature Type protein coding gene
Genetic Map
Chromosome 17
15.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:31255019-31277356 bp, - strand
From NCBI annotation of GRCm38

  22338 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11905  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Rsph1

Human
homologs
Human Homolog RSPH1, radial spoke head 1 homolog (Chlamydomonas)
NCBI Gene ID 89765
neXtProt AC  NX_Q8WYR4
Human Synonyms  CILD24, RSP44, RSPH10A, TSA2, TSGA2
Human Chr (Location)  21q22.3; chr21:42472486-42496354 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RSPH1
Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Gene trapped(50) Targeted(6)
Genomic Mutations involving Rsph1 (4)
 
Mice homozygous for a targeted null mutation exhibit male infertility and azoospermia due to impaired spermatid formation, including deformation of the nucleus/head, acrosome, and flagellar mitochondrial sheath. Homozygous null females are fertile.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Interactions
Rsph1 interacts with 33 markers (Mir22, Mir124a-1, Mir124a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process axoneme assembly, meiotic nuclear division
Component cell projection, chromosome, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (285)    Tissues (162)    Images (41)
Theiler Stages: 13, 15, 17, 20, 22, 23, 26, 28
Assay TypeResults
RNA in situ 267
RT-PCR 18
cDNA source data(46)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(48) cDNA(46) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024033 (Evidence)
Entrez Gene22092 (Evidence)
UniGene12743
DFCITC1580011
DoTSDT.102555712, DT.110575841, DT.489559
NIA Mouse Gene IndexU037647
Consensus CDS ProjectCCDS28604.1
International Mouse Knockout Project StatusRsph1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22092 NCBI Gene Model | MGI Sequence Detail 22338 C57BL/6J ±  kb
transcript NM_025290 RefSeq | MGI Sequence Detail 1164 C57BL/6 
polypeptide Q8VIG3 UniProt | EBI | MGI Sequence Detail 301 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(7)
Polymorphisms RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003409 MORN motif
Protein Ontology PR:000014324 radial spoke head 1
Graphical View of Protein Domain Structure
References (Earliest) J:36973 Taketo MM, et al., Mapping of eight testis-specific genes to mouse chromosomes. Genomics. 1997 Nov 15;46(1):138-42
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory