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Rsph1
Gene Detail
Symbol

Name
ID
Rsph1
radial spoke head 1 homolog (Chlamydomonas)
MGI:1194909
Synonyms
MCA, meichroacidin, Tsga2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
15.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:31255019-31277356 bp, - strand
From NCBI annotation of GRCm38

  22338 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11905  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: RSPH1
Gene Tree: Rsph1

Human
homologs
RSPH1, radial spoke head 1 homolog (Chlamydomonas)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 89765
neXtProt AC: NX_Q8WYR4

Human Synonyms: CT79, RSP44, RSPH10A, TSA2, TSGA2

Human Chr (Location): 21q22.3; chr21:42472486-42496354 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RSPH1

Mutations,
alleles, and
phenotypes
All mutations/alleles(56) : Gene trapped(50) Targeted(6)
Genomic Mutations involving Rsph1 (4)
 
Mice homozygous for a targeted null mutation exhibit male infertility and azoospermia due to impaired spermatid formation, including deformation of the nucleus/head, acrosome, and flagellar mitochondrial sheath. Homozygous null females are fertile.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Rsph1 interacts with 33 markers (Mir22, Mir124a-1, Mir124a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process axoneme assembly, meiotic cell cycle
Component cell projection, chromosome, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (285)    Tissues (163)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 267
RT-PCR 18
cDNA source data(46)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RSPH1 ; Xenbase LOC100489385    NEW 
Molecular
reagents
All nucleic(48) cDNA(46) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000024033 (Evidence)
Entrez Gene 22092 (Evidence)
UniGene 12743
DFCI TC1580011
DoTS DT.110575841, DT.102555712, DT.489559
NIA Mouse Gene Index U037647
Consensus CDS Project CCDS28604.1
International Mouse Phenotyping Consortium Status Rsph1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22092 NCBI Gene Model | MGI Sequence Detail 22338 C57BL/6J ±  kb
transcript NM_025290 RefSeq | MGI Sequence Detail 1164 C57BL/6 
polypeptide Q8VIG3 UniProt | EBI | MGI Sequence Detail 301 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(2) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003409 MORN motif
Protein Ontology PR:000014324 radial spoke head 1
Graphical View of Protein Domain Structure
References
(Earliest) J:36973 Taketo MM, et al., Mapping of eight testis-specific genes to mouse chromosomes. Genomics. 1997 Nov 15;46(1):138-42
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory