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Nfkbie
Gene Detail
 Symbol
Name
ID
Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
MGI:1194908
Feature Type protein coding gene
Genetic Map
Chromosome 17
22.58 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:45555716-45563169 bp, + strand
From NCBI annotation of GRCm38

  7454 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: NF-kappaB inhibitor
Gene Tree: Nfkbie

Human
homologs
Human Homolog NFKBIE, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NCBI Gene ID 4794
neXtProt AC  NX_O00221
Human Synonyms  IKBE
Human Chr (Location)  6p21.1; chr6:44258166-44265788 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions of this gene display an essentially normal phenotype.
 
Interactions
Nfkbie interacts with 161 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process D-serine transport, negative regulation of transcription, DNA-templated
Component cytoplasm, Golgi apparatus, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (57)    Tissues (49)    Images (6)
Theiler Stages: 17, 18, 19, 21, 23, 26, 28
Assay TypeResults
RNA in situ 48
Western blot 9
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000023947 (Evidence)
Entrez Gene18037 (Evidence)
UniGene57043
DFCITC1579267, TC1593718, TC1679839
DoTSDT.101362755, DT.531251
NIA Mouse Gene IndexU018025
Consensus CDS ProjectCCDS28811.1
International Mouse Knockout Project StatusNfkbie
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18037 NCBI Gene Model | MGI Sequence Detail 7454 C57BL/6J ±  kb
transcript NM_008690 RefSeq | MGI Sequence Detail 2422 C57BL/6 
polypeptide O54910 UniProt | EBI | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000003295 NF-kappa-B inhibitor epsilon
Graphical View of Protein Domain Structure
References (Earliest) J:45073 Simeonidis S, et al., Cloning and functional characterization of mouse IkappaBepsilon. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14372-7
(Latest) J:190685 Shih VF, et al., Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-kappaB pathways. Nat Immunol. 2012 Dec;13(12):1162-70
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory