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Nfkbie
Gene Detail
Symbol

Name
ID
Nfkbie
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon
MGI:1194908
Feature Type
protein coding gene
Genetic Map
Chromosome 17
22.58 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:45555716-45563169 bp, + strand
From Ensembl annotation of GRCm38

  7454 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36160  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NFKBIE
Protein SuperFamily: NF-kappaB inhibitor
Gene Tree: Nfkbie

Human
homologs
NFKBIE, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4794
neXtProt AC: NX_O00221

Human Synonyms: IKBE

Human Chr (Location): 6p21.1; chr6:44258166-44265788 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for disruptions of this gene display an essentially normal phenotype.
 
Interactions
Nfkbie interacts with 161 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process D-serine transport, negative regulation of transcription, DNA-templated
Component cytoplasm, Golgi apparatus, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (57)    Tissues (49)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 48
Western blot 9
cDNA source data(26)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nfkbie    NEW 
Molecular
reagents
All nucleic(27) cDNA(27)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000023947 (Evidence)
Entrez Gene 18037 (Evidence)
UniGene 57043
DFCI TC1593718, TC1579267, TC1679839
DoTS DT.531251, DT.101362755
NIA Mouse Gene Index U018025
Consensus CDS Project CCDS28811.1
International Mouse Phenotyping Consortium Status Nfkbie
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023947 Ensembl Gene Model | MGI Sequence Detail 7454 C57BL/6J ±  kb
transcript ENSMUST00000024742 Ensembl | MGI Sequence Detail 2422 Not Applicable 
polypeptide ENSMUSP00000024742 Ensembl | MGI Sequence Detail 364 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
Protein Ontology PR:000003295 NF-kappa-B inhibitor epsilon
References
(Earliest) J:45073 Simeonidis S, et al., Cloning and functional characterization of mouse IkappaBepsilon. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14372-7
(Latest) J:209870 Alves BN, et al., IkappaBepsilon is a key regulator of B cell expansion by providing negative feedback on cRel and RelA in a stimulus-specific manner. J Immunol. 2014 Apr 1;192(7):3121-32
All references(41)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory