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Inpp5k
Gene Detail
Symbol

Name
ID
Inpp5k
inositol polyphosphate 5-phosphatase K
MGI:1194899
Synonyms
C62, PI-5-phosphatase related, Pps, putative PI-5-phosphatase
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:75630988-75648871 bp, + strand
From VEGA annotation of GRCm38

  17884 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Inpp5k

Human
homologs
Human Homolog INPP5K, inositol polyphosphate-5-phosphatase K
NCBI Gene ID 51763
neXtProt AC  NX_Q9BT40
Human Synonyms  PPS, SKIP
Human Chr (Location)  17p13.3; chr17:1494575-1516888 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous disruption of this gene leads to embryonic lethality. Adult heterozygous mutant mice show normal food intake and adiposity but exhibit enhanced glucose homeostasis and insulin sensitivity, increased insulin action in skeletal muscle, and reduced diet-induced obesity.
 
Interactions
Inpp5k interacts with 303 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(82)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(87) Genomic(3) cDNA(84)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000006214 (Evidence)
Ensembl Gene ModelENSMUSG00000006127 (Evidence)
Entrez Gene19062 (Evidence)
UniGene1458
DFCITC1739562, TC1635200, TC1575144
DoTSDT.91328404, DT.531517
NIA Mouse Gene IndexU012956
EC3.1.3.56
Consensus CDS ProjectCCDS25053.1
International Mouse Knockout Project StatusInpp5k
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006214 VEGA Gene Model | MGI Sequence Detail 17884 C57BL/6J ±  kb
transcript OTTMUST00000014028 VEGA | MGI Sequence Detail 2679 Not Applicable 
polypeptide OTTMUSP00000006518 VEGA | MGI Sequence Detail 468 Not Applicable 

For the selected sequences
All sequences(57) RefSeq(7) UniProt(9)
Polymorphisms
SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
InterPro IPR000300 Inositol polyphosphate-related phosphatase
Protein Ontology PR:000009052 inositol polyphosphate 5-phosphatase K
References
(Earliest) J:6513 D'Eustachio P, et al., Chromosomal distribution of ribosomal protein genes in the mouse. Cell. 1981 May;24(2):307-12
(Latest) J:192972 Ijuin T, et al., Role of phosphatidylinositol 3,4,5-trisphosphate (PIP3) 5-phosphatase skeletal muscle- and kidney-enriched inositol polyphosphate phosphatase (SKIP) in myoblast differentiation. J Biol Chem. 2012 Sep 7;287(37):31330-41
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory