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Inpp5k Gene Detail
Summary
  • Symbol
    Inpp5k
  • Name
    inositol polyphosphate 5-phosphatase K
  • Synonyms
    C62, PI-5-phosphatase related, Pps, putative PI-5-phosphatase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194899
    NCBI Gene: 19062
  • Gene Overview
    MyGene.info: INPP5K
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75630988-75648871 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 45.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194899
protein coding gene Chr11:75630507-75648871 (.)
129S1/SvImJ MGP_129S1SvImJ_G0018719
protein coding gene Chr11:76393866-76414487 (+)
A/J MGP_AJ_G0018685
protein coding gene Chr11:73548657-73566942 (+)
AKR/J MGP_AKRJ_G0018655
protein coding gene Chr11:75775871-75793521 (+)
BALB/cJ MGP_BALBcJ_G0018659
protein coding gene Chr11:73928002-73946912 (+)
C3H/HeJ MGP_C3HHeJ_G0018472
protein coding gene Chr11:75792158-75812456 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019110
protein coding gene Chr11:78807004-78827411 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016745
protein coding gene Chr11:70562169-70579570 (+)
CAST/EiJ MGP_CASTEiJ_G0018026
protein coding gene Chr11:76189848-76207342 (+)
CBA/J MGP_CBAJ_G0018442
protein coding gene Chr11:82251520-82276927 (+)
DBA/2J MGP_DBA2J_G0018551
protein coding gene Chr11:73152348-73170497 (+)
FVB/NJ MGP_FVBNJ_G0018541
protein coding gene Chr11:72714831-72733833 (+)
LP/J MGP_LPJ_G0018622
protein coding gene Chr11:76976522-76997573 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018567
protein coding gene Chr11:82796389-82814656 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019150
protein coding gene Chr11:75990289-76010704 (+)
PWK/PhJ MGP_PWKPhJ_G0017797
protein coding gene Chr11:73855045-73877303 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017588
protein coding gene Chr11:75542380-75562210 (+)
WSB/EiJ MGP_WSBEiJ_G0018079
protein coding gene Chr11:75801842-75821778 (+)



Homology
more
  • Human Ortholog
    INPP5K, inositol polyphosphate-5-phosphatase K
  • Vertebrate Orthologs
    11
  • Human Ortholog
    INPP5K, inositol polyphosphate-5-phosphatase K
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MDCCAID, PPS, SKIP
  • Links
    NCBI Gene ID: 51763
    neXtProt AC: NX_Q9BT40
    UniProt: Q9BT40

  • Chr Location
    17p13.3; chr17:1494575-1516888 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 75059
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: INPP5K
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human INPP5K associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene leads to embryonic lethality. Adult heterozygous mutant mice show normal food intake and adiposity but exhibit enhanced glucose homeostasis and insulin sensitivity, increased insulin action in skeletal muscle, and reduced diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000006127 Ensembl Gene Model | MGI Sequence Detail 17884 C57BL/6J ±  kb
    transcript ENSMUST00000006286 Ensembl | MGI Sequence Detail 2679 Not Applicable  
    polypeptide ENSMUSP00000006286 Ensembl | MGI Sequence Detail 468 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 3
      cDNA 85

      Microarray probesets 5
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:235828 Ijuin T, et al., Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance. Mol Cell Biol. 2016 Jan 1;36(1):108-18

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory