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Ppl Gene Detail
Summary
  • Symbol
    Ppl
  • Name
    periplakin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194898
    NCBI Gene: 19041
  • Gene Overview
    MyGene.info: PPL
Location & Maps
more
  • Sequence Map
    Chr16:5086291-5132481 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46191 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 2.50 cM, cytoband A-B1
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    PPL, periplakin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PPL, periplakin
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 5493
    neXtProt AC: NX_O60437

  • Chr Location
    16p13.3; chr16:4882507-4937135 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2026
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PPL
  • Gene Tree
    Ppl
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Homozygous null mice are fertile and grossly normal with no apparent skin abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19041 NCBI Gene Model | MGI Sequence Detail 46191 C57BL/6J ±  kb
transcript NM_008909 RefSeq | MGI Sequence Detail 6277 C57BL/6  
polypeptide Q9R269 UniProt | EBI | MGI Sequence Detail 1755 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    237 from dbSNP Build 142
  • PCR
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 3
    cDNA 29
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146664
References
more
  • Summaries
    All 42
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:45028 Ruhrberg C, et al., Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin. J Cell Biol. 1997 Dec 29;139(7):1835-49
  • Latest
    J:229913 Natsuga K, et al., Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility. J Invest Dermatol. 2016 Jan;136(1):99-106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory