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Gpc5 Gene Detail
Summary
  • Symbol
    Gpc5
  • Name
    glypican 5
  • Synonyms
    A230034F01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194894
    NCBI Gene: 103978
  • Gene Overview
    MyGene.info: GPC5
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:115092215-116525179 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 59.43 cM, cytoband E4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4723 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194894
protein coding gene Chr14:115092212-116525192 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021644
protein coding gene Chr14:112549865-114040770 (+)
A/J MGP_AJ_G0021603
protein coding gene Chr14:108300147-109702958 (+)
AKR/J MGP_AKRJ_G0021579
protein coding gene Chr14:111831423-113283646 (+)
BALB/cJ MGP_BALBcJ_G0021609
protein coding gene Chr14:108815586-110232601 (+)
C3H/HeJ MGP_C3HHeJ_G0021387
protein coding gene Chr14:111656700-113127648 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022049
protein coding gene Chr14:116881106-118455037 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019588
protein coding gene Chr14:104467326-105820784 (+)
CAST/EiJ MGP_CASTEiJ_G0020903
protein coding gene Chr14:109434925-110948393 (+)
CBA/J MGP_CBAJ_G0021355
protein coding gene Chr14:121418844-123058554 (+)
DBA/2J MGP_DBA2J_G0021478
protein coding gene Chr14:108216969-109624295 (+)
FVB/NJ MGP_FVBNJ_G0021456
protein coding gene Chr14:106562747-107958966 (+)
LP/J MGP_LPJ_G0021546
protein coding gene Chr14:113575441-115061091 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021483
protein coding gene Chr14:126298608-128093208 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022072
protein coding gene Chr14:111263605-112707211 (+)
PWK/PhJ MGP_PWKPhJ_G0020647
protein coding gene Chr14:105163805-106592765 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020485
protein coding gene Chr14:107399961-108915039 (+)
WSB/EiJ MGP_WSBEiJ_G0020958
protein coding gene Chr14:112004909-113504366 (+)



Homology
more
  • Human Ortholog
    GPC5, glypican 5
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPC5, glypican 5
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 2262
    neXtProt AC: NX_P78333
    UniProt: P78333

  • Chr Location
    13q31.3; chr13:91398619-92867237 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022112 Ensembl Gene Model | MGI Sequence Detail 1432965 C57BL/6J ±  kb
    transcript ENSMUST00000176912 Ensembl | MGI Sequence Detail 2837 Not Applicable  
    polypeptide ENSMUSP00000135085 Ensembl | MGI Sequence Detail 645 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 10
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2442523
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 9
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:45283 Saunders S, et al., Expression of the cell surface proteoglycan glypican-5 is developmentally regulated in kidney, limb, and brain. Dev Biol. 1997 Oct 1;190(1):78-93
    • Latest
      J:230611 Dierker T, et al., Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones. Matrix Biol. 2016 Jan;49:82-92

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory