Evl
Gene Detail

Symbol Name ID

Evl Ena-vasodilator stimulated phosphoprotein MGI:1194884

Feature Type

protein coding gene

Genetic Map

Chromosome 12

59.46 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:108554720-108688513 bp, + strand From Ensembl annotation of GRCm38   133794 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56752  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: vasodilator-stimulated phosphoprotein
Gene Tree: Evl

Human homologs

Human Homolog		EVL, Enah/Vasp-like
NCBI Gene ID		51466
neXtProt AC		NX_Q9UI08
Human Synonyms		RNB6
Human Chr (Location)		14q32.2; chr14:100019382-100144236 (+)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a knock-out allele are viable with no apparent defects in gross morphology or histology. Mice homozygous for a different knock-out allele are viable and fertile but display defects in monocyte migration.

 

Interactions

Evl interacts with 60 markers (Mir15a, Mir20a, Mir20b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	actin filament-based movement, actin nucleation, ...
Component	cell projection, cytoplasm, ...
Function	actin binding, profilin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (82)    Tissues (59)    Images (13)
Theiler Stages: 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	40
Western blot	42

cDNA source data(99)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(100) cDNA(100)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000021262 (Evidence)
Entrez Gene	14026 (Evidence)
UniGene	238841
DFCI	TC1575194, TC1589894, TC1610671
NIA Mouse Gene Index	U014372
PDB	1QC6
Consensus CDS Project	CCDS26161.1, CCDS49167.1, CCDS49168.1, CCDS49169.1
International Mouse Knockout Project Status	Evl

Sequences

Length	Strain/Species
genomic	ENSMUSG00000021262	Ensembl Gene Model | MGI Sequence Detail	133794	C57BL/6J
transcript	ENSMUST00000021689	Ensembl | MGI Sequence Detail	2181	Not Applicable
polypeptide	ENSMUSP00000021689	Ensembl | MGI Sequence Detail	414	Not Applicable

All sequences(45) RefSeq(12) UniProt(4)

Polymorphisms

SNPs within 2kb(1018 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000697	EVH1
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017354	Vasodilator-stimulated phosphoprotein
InterPro	IPR014885	VASP tetramerisation
Protein Ontology	PR:000007239	ena/VASP-like protein

References

(Earliest) J:44192 Gertler FB, et al., Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996 Oct 18;87(2):227-39
(Latest) J:205619 Mouneimne G, et al., Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell. 2012 Nov 13;22(5):615-30
All references(44)

Other accession IDs

MGI:2144857