About   Help   FAQ
Evl Gene Detail
Summary
  • Symbol
    Evl
  • Name
    Ena-vasodilator stimulated phosphoprotein
  • Synonyms
    b2b2600Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194884
    NCBI Gene: 14026
  • Gene Overview
    MyGene.info: EVL
Location & Maps
more
  • Sequence Map
    Chr12:108554720-108688516 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      133797 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 59.46 cM, cytoband F2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EVL, Enah/Vasp-like
  • Vertebrate Orthologs
    7
  • Human Ortholog
    EVL, Enah/Vasp-like
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RNB6
  • Links
    NCBI Gene ID: 51466
    neXtProt AC: NX_Q9UI08
    UniProt: Q9UI08

  • Chr Location
    14q32.2; chr14:99971454-100144236 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    9 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable with no apparent defects in gross morphology or histology. Mice homozygous for a different knock-out allele are viable and fertile but display defects in monocyte migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    94
  • Tissues
    71
  • cDNA Data
    99
  • Literature Summary
    8
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14026 NCBI Gene Model | MGI Sequence Detail 133797 C57BL/6J ±  kb
transcript NM_001163394 RefSeq | MGI Sequence Detail 2202 C57BL/6  
polypeptide P70429 UniProt | EBI | MGI Sequence Detail 414 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1008 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 100
    cDNA 100

    Microarray probesets 5
Other
Accession IDs
less
MGI:2144857, MGI:5560789
References
more
  • Summaries
    All 47
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:44192 Gertler FB, et al., Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996 Oct 18;87(2):227-39
  • Latest
    J:242034 Estin ML, et al., Ena/VASP proteins regulate activated T-cell trafficking by promoting diapedesis during transendothelial migration. Proc Natl Acad Sci U S A. 2017 Apr 04;114(14):E2901-E2910
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
08/08/2017
MGI 6.10 		The Jackson Laboratory