Evl MGI Mouse Gene Detail - MGI:1194884 - Ena-vasodilator stimulated phosphoprotein

Evl Gene Detail

Symbol

Evl
Name

Ena-vasodilator stimulated phosphoprotein

Feature Type

protein coding gene
IDs

MGI:1194884
NCBI Gene: 14026
Gene Overview

MyGene.info: EVL

Sequence Map

Chr12:108554720-108688513 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
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Sequence

133794 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 59.46 cM, cytoband F2
Mapping Data

3 experiments

Human Ortholog

EVL, Enah/Vasp-like

Vertebrate Orthologs

7

Human Ortholog

EVL, Enah/Vasp-like
Orthology source: HomoloGene, HGNC
Synonyms

RNB6
Links

HGNC:20234

NCBI Gene ID: 51466

neXtProt AC: NX_Q9UI08
Chr Location

14q32.2; chr14:100019387-100144236 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 56752
1 human;1 mouse;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken
HCOP

human homology predictions: EVL
Protein SuperFamily

vasodilator-stimulated phosphoprotein
Gene Tree

Evl

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Phenotype Summary

5 phenotypes from 3 alleles in 3 genetic backgrounds
16 phenotypes from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC

Mice homozygous for a knock-out allele are viable with no apparent defects in gross morphology or histology. Mice homozygous for a different knock-out allele are viable and fertile but display defects in monocyte migration.

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All GO Annotations

26
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

94
Tissues

71
cDNA Data

99
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase evl

ZFIN evla, evlb

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Evl interacts with 59 markers (Mir15a, Mir20a, Mir20b, ...) View All

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All Sequences

42
RefSeq

12
UniProt

4
CCDS

CCDS26161.1, CCDS49167.1, CCDS49168.1, CCDS49169.1
UniGene

238841

Ensembl

ENSMUSG00000021262 (Evidence)
NCBI Gene

14026

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021262	Ensembl Gene Model \| MGI Sequence Detail	133794	C57BL/6J	± kb
transcript	ENSMUST00000021689	Ensembl \| MGI Sequence Detail	2181	Not Applicable
polypeptide	ENSMUSP00000021689	Ensembl \| MGI Sequence Detail	414	Not Applicable

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SNPs within 2kb

1008 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000007239 ena/VASP-like protein
PDB

1QC6
InterPro Domains

IPR011993 PH domain-like

IPR017354 Vasodilator-stimulated phosphoprotein

IPR014885 VASP tetramerisation

IPR000697 WH1/EVH1 domain

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All nucleic 100

cDNA 100

Microarray probesets 5

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MGI:2144857

Summaries

All 42

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 9
Earliest

J:44192 Gertler FB, et al., Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996 Oct 18;87(2):227-39
Latest

J:228563 Koscielny G, et al., The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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