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Evl
Gene Detail
Symbol

Name
ID
Evl
Ena-vasodilator stimulated phosphoprotein
MGI:1194884
Feature Type
protein coding gene
Genetic Map
Chromosome 12
59.46 cM, cytoband F2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:108554720-108688513 bp, + strand
From Ensembl annotation of GRCm38

  133794 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56752  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: EVL
Protein SuperFamily: vasodilator-stimulated phosphoprotein
Gene Tree: Evl

Human
homologs
EVL, Enah/Vasp-like
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 51466
neXtProt AC: NX_Q9UI08

Human Synonyms: RNB6

Human Chr (Location): 14q32.2; chr14:100019387-100144236 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele are viable with no apparent defects in gross morphology or histology. Mice homozygous for a different knock-out allele are viable and fertile but display defects in monocyte migration.
 
Interactions
Evl interacts with 59 markers (Mir15a, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process actin filament-based movement, actin nucleation, ...
Component cell projection, cytoplasm, ...
Function actin binding, profilin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (82)    Tissues (67)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 40
Western blot 42
cDNA source data(99)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase evl ; ZFIN evla, evlb    NEW 
Molecular
reagents
All nucleic(100) cDNA(100)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000021262 (Evidence)
Entrez Gene 14026 (Evidence)
UniGene 238841
DFCI TC1589894, TC1610671, TC1575194
NIA Mouse Gene Index U014372
PDB 1QC6
Consensus CDS Project CCDS26161.1, CCDS49167.1, CCDS49168.1, CCDS49169.1
International Mouse Phenotyping Consortium Status Evl
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021262 Ensembl Gene Model | MGI Sequence Detail 133794 C57BL/6J ±  kb
transcript ENSMUST00000021689 Ensembl | MGI Sequence Detail 2181 Not Applicable 
polypeptide ENSMUSP00000021689 Ensembl | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(1018 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000697 EVH1
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017354 Vasodilator-stimulated phosphoprotein
InterPro IPR014885 VASP tetramerisation
Protein Ontology PR:000007239 ena/VASP-like protein
References
(Earliest) J:44192 Gertler FB, et al., Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996 Oct 18;87(2):227-39
(Latest) J:205619 Mouneimne G, et al., Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell. 2012 Nov 13;22(5):615-30
All references(43)
Other
accession IDs
MGI:2144857

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory