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Irs3 Gene Detail
Summary
  • Symbol
    Irs3
  • Name
    insulin receptor substrate 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194882
    NCBI Gene: 16369
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137641294-137643976 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.59 cM, cytoband G2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194882
 protein coding gene Chr5:137641293-137643976 (-)
129S1/SvImJ ENSMUSG00200044511
 protein coding gene Chr5:131436919-131439600 (-)
A/J ENSMUSG00195047384
 protein coding gene Chr5:130939494-130942177 (-)
AKR/J ENSMUSG00220044964
 protein coding gene Chr5:130414784-130417466 (-)
BALB/cJ ENSMUSG00180040182
 protein coding gene Chr5:131036056-131038739 (-)
C3H/HeJ ENSMUSG00175046771
 protein coding gene Chr5:132963571-132966254 (-)
C57BL/6NJ ENSMUSG00215044843
 protein coding gene Chr5:131084907-131087590 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027887
 protein coding gene Chr5:130451532-130454673 (-)
CAST/EiJ ENSTCUG00005009766
 protein coding gene Chr5:130307173-130309849 (-)
CBA/J ENSMUSG00210023345
 protein coding gene Chr5:131781136-131783820 (-)
DBA/2J ENSMUSG00185053069
 protein coding gene Chr5:134796504-134799187 (-)
FVB/NJ ENSMUSG00205048215
 protein coding gene Chr5:130680249-130682932 (-)
JF1/MsJ ENSUMUG00000043656
 protein coding gene Chr5:137692089-137694768 (-)
LP/J ENSMUSG00230042386
 protein coding gene Chr5:138909969-138912652 (-)
NOD/ShiLtJ ENSMUSG00190034360
 protein coding gene Chr5:130735792-130738475 (-)
NZO/HlLtJ ENSMUSG00225023421
 protein coding gene Chr5:146584907-146587588 (-)
PWK/PhJ ENSLUMG00010017356
 protein coding gene Chr5:129545562-129548245 (-)
SPRET/EiJ ENSMSPG00010037938
 protein coding gene Chr5:132943178-132945858 (-)
WSB/EiJ ENSIUOG00005035533
 protein coding gene Chr5:133386614-133389296 (-)



Homology
more
  • Human Ortholog
    IRS3P, insulin receptor substrate 3, pseudogene
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRS3P, insulin receptor substrate 3, pseudogene
  • Synonyms
    IRS3L
  • Links
    NCBI Gene ID: 442338

  • Chr Location
    7q22.1; chr7:100570131-100571401 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    15 phenotypes from multigenic genotypes
    6 phenotype references
Mice homozygous for a targeted mutation are viable, fertile and display no detectable abnormalities in growth or glucose homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    12
  • cDNA Data
    11
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16369 NCBI Gene Model | MGI Sequence Detail 2683 C57BL/6J ±  kb
transcript NM_010571 RefSeq | MGI Sequence Detail 2337 C57BL/6  
polypeptide NP_034701 RefSeq | MGI Sequence Detail 495 C57BL/6  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 3
    cDNA 11

    Microarray probesets 3
Other
Accession IDs
less
MGI:2140734
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:43854 Sciacchitano S, et al., Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene. Endocrinology. 1997 Nov;138(11):4931-40
  • Latest
    J:262992 Zhuang L, et al., Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Nat Commun. 2018 May 4;9(1):1796
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory