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Psmb5
Gene Detail
 Symbol
Name
ID
Psmb5
proteasome (prosome, macropain) subunit, beta type 5
MGI:1194513
Feature Type protein coding gene
Genetic Map
Chromosome 14
27.86 cM, cytoband C2-D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:54614120-54617995 bp, - strand
From NCBI annotation of GRCm38

  3876 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55690  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Psmb5

Human
homologs
Human Homolog PSMB5, proteasome (prosome, macropain) subunit, beta type, 5
NCBI Gene ID 5693
neXtProt AC  NX_P28074
Human Synonyms  LMPX, MB1, X
Human Chr (Location)  14q11.2; chr14:23016543-23035220 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from APF )
Interactions
Psmb5 interacts with 6 markers (Mir139, Mir202, Mir377, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process proteasome-mediated ubiquitin-dependent protein catabolic process, proteolysis, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function endopeptidase activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Images (1)
Theiler Stages: 23
Assay TypeResults
RNA in situ 1
cDNA source data(142)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(144) Genomic(1) cDNA(142) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000022193 (Evidence)
Entrez Gene19173 (Evidence)
UniGene8911
DFCITC1572650, TC1590944, TC1744739
DoTSDT.55107717, DT.55112682
NIA Mouse Gene IndexU035557, U372614
EC3.4.25.1
PDB3UNB, 3UNE
Consensus CDS ProjectCCDS27095.1
International Mouse Knockout Project StatusPsmb5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19173 NCBI Gene Model | MGI Sequence Detail 3876 C57BL/6J ±  kb
transcript NM_011186 RefSeq | MGI Sequence Detail 871 B10.A-H2 
polypeptide O55234 UniProt | EBI | MGI Sequence Detail 264 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(2)
Polymorphisms PCR(1) : SNPs within 2kb(101 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000243 Peptidase T1A, proteasome beta-subunit
InterPro IPR016050 Proteasome, beta-type subunit, conserved site
InterPro IPR023333 Proteasome B-type subunit
InterPro IPR001353 Proteasome, subunit alpha/beta
Protein Ontology PR:000013373 proteasome subunit beta type-5
Graphical View of Protein Domain Structure
References (Earliest) J:44713 Kohda K, et al., Structural analysis and chromosomal localization of the mouse Psmb5 gene coding for the constitutively expressed beta-type proteasome subunit. Immunogenetics. 1997;47(1):77-87
(Latest) J:191966 Wang X, et al., Pno1 tissue-specific expression and its functions related to the immune responses and proteasome activities. PLoS One. 2012;7(9):e46093
All references(33)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory