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C1qbp Gene Detail
Summary
  • Symbol
    C1qbp
  • Name
    complement component 1, q subcomponent binding protein
  • Synonyms
    D11Wsu182e, HABP1, P32
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194505
    NCBI Gene: 12261
  • Gene Overview
    MyGene.info: C1QBP
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:70977846-70983026 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 43.21 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194505
protein coding gene Chr11:70977836-70983026 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018620
protein coding gene Chr11:71553322-71559714 (-)
A/J MGP_AJ_G0018588
protein coding gene Chr11:68833840-68839050 (-)
AKR/J MGP_AKRJ_G0018557
protein coding gene Chr11:70908316-70913518 (-)
BALB/cJ MGP_BALBcJ_G0018560
protein coding gene Chr11:69144079-69149269 (-)
C3H/HeJ MGP_C3HHeJ_G0018373
protein coding gene Chr11:70936164-70941357 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019011
protein coding gene Chr11:73721469-73726659 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016656
protein coding gene Chr11:65739254-65744715 (-)
CAST/EiJ MGP_CASTEiJ_G0017928
protein coding gene Chr11:71214726-71219920 (-)
CBA/J MGP_CBAJ_G0018345
protein coding gene Chr11:77041961-77049016 (-)
DBA/2J MGP_DBA2J_G0018455
protein coding gene Chr11:68413752-68418989 (-)
FVB/NJ MGP_FVBNJ_G0018445
protein coding gene Chr11:68056976-68062176 (-)
LP/J MGP_LPJ_G0018525
protein coding gene Chr11:72133497-72139000 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018468
protein coding gene Chr11:77583202-77588406 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019053
protein coding gene Chr11:71166204-71171403 (-)
PWK/PhJ MGP_PWKPhJ_G0017702
protein coding gene Chr11:69068025-69073359 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017492
protein coding gene Chr11:70975502-70980696 (-)
WSB/EiJ MGP_WSBEiJ_G0017982
protein coding gene Chr11:70829498-70836197 (-)



Homology
more
  • Human Ortholog
    C1QBP, complement C1q binding protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    C1QBP, complement C1q binding protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    COXPD33, GC1QBP, gC1qR, gC1Q-R, HABP1, p32, SF2AP32, SF2p32
  • Links
    NCBI Gene ID: 708
    neXtProt AC: NX_Q07021
    UniProt: Q07021

  • Chr Location
    17p13.2; chr17:5432779-5439151 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31023
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: C1QBP
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality by E11.5 with poor development, small embryo size, pale and anemic organs, poor cellular proliferation and impaired mitochondrial electron transport chain function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12261 NCBI Gene Model | MGI Sequence Detail 5181 C57BL/6J ±  kb
    transcript NM_007573 RefSeq | MGI Sequence Detail 1177 C57BL/6  
    polypeptide O35658 UniProt | EBI | MGI Sequence Detail 278 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR003428 Mitochondrial glycoprotein
      IPR036561 Mitochondrial glycoprotein superfamily
    Molecular
    Reagents
    less
    • All nucleic 161
      Genomic 7
      cDNA 153
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36447, MGI:107870, MGI:2143969, MGI:2144060
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 18
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:255777 Yagi M, et al., Neural-specific deletion of mitochondrial p32/C1qbp leads to leukoencephalopathy due to undifferentiated oligodendrocyte and axon degeneration. Sci Rep. 2017 Nov 9;7(1):15131

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory